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Details of CPPsite entry with Sequence rqikiwfqnrrmkwkk
Primary information
PEPTIDE SEQUENCErqikiwfqnrrmkwkk
CPPsite ID 2162, 2451, 2900, 1092, 1822, 1823,
PEPTIDE NAMEPenetratin, Penetratin, D-Penetratin, D form of pAntpHD (43-58), Penetratin {pAntp-(43-58)}, Penetratin {pAntp-(43-58)}
CHIRALITYD, D, D, D, D, D
LINEAR/CYCLICLinear, Linear, Linear, Linear, Linear, Linear
SOURCEProtein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived
CATEGORYCationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, Amphipathic, Amphipathic, Amphipathic
SUB CELLULAR LOCALIZATIONNA, NA, NA, Cytoplasm and nucleus, Vesicles and membrane bound, Membrane bound
N-TERMINAL MODIFICATIONFree, Free, Free, Biotinylation, Conjugation with fluorescein, Conjugation with fluorescein
C-TERMINAL MODIFICATIONFree, Free, Free, Amidation, Amidation, Amidation
CHEMICAL MODIFICATIONNA, NA, NA, NA, NA, NA
UPTAKE EFFICIENCYHigher than control insulin and L penetratin, Lower degradation rate, NA, Similar to (pAntp) (43-58), Unknown, Unknown
PROPOSED UPTAKE MECHANISMNA, Energy-independent pathway, NA, Non-receptor mdiated endocytic pathway, Unknown, Unknown
INVITRO/INVIVOIn vivo, In vitro, In vivo, In vitro, In vitro, In vitro
CELL LINENA, None, NA, Cortical striatal cells, HeLa, MC57
In VIVO MODELSeven weeks old male ddY mice, male Sprague Dawley rats, Male ddY mice, Male ddY mice, NA, NA, NA
CARGOProtein (Insulin), Protein (Insulin), Protein (Insulin), Biotin, Fluorophore (fluorescein), Fluorophore (fluorescein)
PMID24973720, 24973720, 25445695, 8663410, 21867915, 21867915
PATENTUnknown, Unknown, Unknown, Unknown, Unknown, Unknown
Tertiary Structure
(Technique)		2162 (PEPstrMOD), 2451 (Experimentally determined structure from PDB), 2900 (PEPstrMOD), 1092 (Experimentally determined structure from PDB), 1822 (Experimentally determined structure from PDB), 1823 (Experimentally determined structure from PDB),