Welcome to Sequence Card of Peptide
Details of CPPsite entry with Sequence rrrrrrrr |
| Primary information | |
|---|---|
| PEPTIDE SEQUENCE | rrrrrrrr |
| CPPsite ID | 2698, 2711, 2745, 2786, 2789, 2849, 1042, 1205, 1845, |
| PEPTIDE NAME | dR8-p53C', r8_carbamate_CF15 (VI), r8, d-R8-C6-NP, d-R8-INS-NP, Oligoarginine, D-R8, R8, r8 |
| CHIRALITY | D, Modified, D, D, D, D, D, D, D |
| LINEAR/CYCLIC | Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear |
| SOURCE | Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic |
| CATEGORY | Cationic, NA, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic |
| SUB CELLULAR LOCALIZATION | Cytosol, Cytoplasm, Cytosol and nucleoli, NA, NA, NA, Probably cytoplasm and nucleus, Vesicles, Cytoplasm and nucleus and nucleolus at 4 degrre, while in vesicle at 37 de |
| N-TERMINAL MODIFICATION | NA, NA, NA, Free, Free, Conjugated with linker, Conjugation with fluorescein with 6-aminohexanoic acid (Ahx) spacer, Conjugation with K-FITC, Free |
| C-TERMINAL MODIFICATION | Amidation, NA, NA, Free, Free, Conjugation with Glycine, Free, Free, Labelled at the C-terminal cysteine using Alexa Fl |
| CHEMICAL MODIFICATION | NA, NA, NA, NA, NA, NA, NA, NA, NA |
| UPTAKE EFFICIENCY | NA, Low (compare to II), NA, NA, NA, NA, High (relative to both Tat (49-57) and R7), Lower than CyLoP1, Unknown |
| PROPOSED UPTAKE MECHANISM | NA, Energy dependent process, Direct membrane translocation, NA, NA, Clathrin-mediated endocytosis and macropinocytosis, Probably non-endocytic pathway, Probably endocytic process, Unknown |
| INVITRO/INVIVO | In vitro, In vitro, In vitro and in vivo, In vitro, In vitro, In vitro and in vivo, In vitro, In vitro, In vitro |
| CELL LINE | HeLa, T98G glioma cells, CHO-K1, HeLa cells, Caco-2 cells, Caco-2 cells, PC-3 cells, Jurkat, NIH-3T3, KG1a cells |
| In VIVO MODEL | NA, NA, Female Kunming (KM) mice, NA, NA, Male BALB/c nude mice (22Rv1 xenograft murine model), NA, NA, NA |
| CARGO | Protein (p53), Nucleic acid (plasmid DNA), Fluorophore (FITC), Nanoparticle (Couramin-6 loaded nanoparticle), Nanoparticle (Insulin loaded nanoparticle), Nanoparticle (Liposomes), Fluorophore (fluorescein), Fluorophore (FITC), Fluorophore (Alexa FI) |
| PMID | 22486588, 22509923, 22824782, 23538098, 23538098, 23777916, 11087855, 21319732, 17217340 |
| PATENT | Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, US 6593292, Unknown, Unknown |
| Tertiary Structure (Technique) | 2698 (PEPstrMOD), 2711 (PEPstrMOD), 2745 (PEPstrMOD), 2786 (PEPstrMOD), 2789 (PEPstrMOD), 2849 (PEPstrMOD), 1042 (PEPstrMOD), 1205 (PEPstrMOD), 1845 (PEPstrMOD), |