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Details of CPPsite entry with Sequence rrrrrrrr
Primary information
PEPTIDE SEQUENCErrrrrrrr
CPPsite ID 2698, 2711, 2745, 2786, 2789, 2849, 1042, 1205, 1845,
PEPTIDE NAMEdR8-p53C', r8_carbamate_CF15 (VI), r8, d-R8-C6-NP, d-R8-INS-NP, Oligoarginine, D-R8, R8, r8
CHIRALITYD, Modified, D, D, D, D, D, D, D
LINEAR/CYCLICLinear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear
SOURCESynthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic
CATEGORYCationic, NA, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic
SUB CELLULAR LOCALIZATIONCytosol, Cytoplasm, Cytosol and nucleoli, NA, NA, NA, Probably cytoplasm and nucleus, Vesicles, Cytoplasm and nucleus and nucleolus at 4 degrre, while in vesicle at 37 de
N-TERMINAL MODIFICATIONNA, NA, NA, Free, Free, Conjugated with linker, Conjugation with fluorescein with 6-aminohexanoic acid (Ahx) spacer, Conjugation with K-FITC, Free
C-TERMINAL MODIFICATIONAmidation, NA, NA, Free, Free, Conjugation with Glycine, Free, Free, Labelled at the C-terminal cysteine using Alexa Fl
CHEMICAL MODIFICATIONNA, NA, NA, NA, NA, NA, NA, NA, NA
UPTAKE EFFICIENCYNA, Low (compare to II), NA, NA, NA, NA, High (relative to both Tat (49-57) and R7), Lower than CyLoP1, Unknown
PROPOSED UPTAKE MECHANISMNA, Energy dependent process, Direct membrane translocation, NA, NA, Clathrin-mediated endocytosis and macropinocytosis, Probably non-endocytic pathway, Probably endocytic process, Unknown
INVITRO/INVIVOIn vitro, In vitro, In vitro and in vivo, In vitro, In vitro, In vitro and in vivo, In vitro, In vitro, In vitro
CELL LINEHeLa, T98G glioma cells, CHO-K1, HeLa cells, Caco-2 cells, Caco-2 cells, PC-3 cells, Jurkat, NIH-3T3, KG1a cells
In VIVO MODELNA, NA, Female Kunming (KM) mice, NA, NA, Male BALB/c nude mice (22Rv1 xenograft murine model), NA, NA, NA
CARGOProtein (p53), Nucleic acid (plasmid DNA), Fluorophore (FITC), Nanoparticle (Couramin-6 loaded nanoparticle), Nanoparticle (Insulin loaded nanoparticle), Nanoparticle (Liposomes), Fluorophore (fluorescein), Fluorophore (FITC), Fluorophore (Alexa FI)
PMID22486588, 22509923, 22824782, 23538098, 23538098, 23777916, 11087855, 21319732, 17217340
PATENTUnknown, Unknown, Unknown, Unknown, Unknown, Unknown, US 6593292, Unknown, Unknown
Tertiary Structure
(Technique)
2698 (PEPstrMOD), 2711 (PEPstrMOD), 2745 (PEPstrMOD), 2786 (PEPstrMOD), 2789 (PEPstrMOD), 2849 (PEPstrMOD), 1042 (PEPstrMOD), 1205 (PEPstrMOD), 1845 (PEPstrMOD),