Designing of Peptides for Desired Toxicity

This tool allows users to predict toxicity of their peptide as well as provides options to identify mutations in peptide for increasing or decreasing toxicity of peptide. It generate all possible mutants of given peptide (all possible single mutations) and predict toxicity of each mutant along with all the important physico-chemical properties like hydrophobicity, charge, pI etc. As a possible application, user can identify and alter a particular residue, which can reduce the toxicity of the peptide drastically. For more information clickHelp.

Type or paste amino acid sequence of peptide in single letter code:


Select prediction method: SVM (Swiss-Prot) based   SVM (Swiss-Prot) + Motif based   SVM (TrEMBL) based   SVM (TrEMBL) + Motif based      


Select Quantitative Matrix (QM) method: Monopeptide(Swiss-Prot)   Monopeptide (TrEMBL)  Dipeptide (Swiss-Prot)   Dipeptide (TrEMBL)      

Choose E-value cut-off for motif-based method:    

Choose SVM threshold:    

Physicochemical Properties to Be Displayed:
 Hydrophobicity     Sterichinderance     Side bulk     Hydropathicity     Amphipathicity     Hydrophilicity     Net Hydrogen     Charge
 pI     Molecular weight  All