QMS Calculator

This tool allows the users alter a therapeutic peptide with minimum mutations, based on Quantitative matrix, so that its activity may remain same but toxicity reduces. Here user can submit query peptide in FASTA format and optimize the peptide to get maximum/minimum/desired toxicity based upon the Quantitative Matrix based position specific scores. It will help the user to tweak any residue from the predecessor peptide to attain the analog with desired property (highest/lowest toxicity). Also, values of highest/lowest scoring residues at corresponding positions is given. To assist further, the cumulative sum of QM Scores for each residue. For more information click Help.

Type or paste peptide sequence(s) in single letter code (in FASTA format):

Select Quantitative Matrix: Monopeptide(Swiss-Prot)   Monopeptide (TrEMBL)