Welcome to Sequence Card of Peptide
Details of CPPsite entry with Sequence KLALKLALKALKAALKLA |
| Primary information | |
|---|---|
| PEPTIDE SEQUENCE | KLALKLALKALKAALKLA |
| CPPsite ID | 2172, 2493, 2652, 2826, 2948, 1061, 1762, |
| PEPTIDE NAME | MAP, MAP, Cyt c-ss-MAP, MAP, C2, I, PN159 (SEQ ID NO: 13) |
| CHIRALITY | L, L, L, L, L, L, L |
| LINEAR/CYCLIC | Linear, Linear, Linear, Linear, Linear, Linear, Linear |
| SOURCE | Protein derived, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic |
| CATEGORY | Amphipathic, Amphipathic, Amphipathic, Amphipathic, NA, Amphipathic, Unknown |
| SUB CELLULAR LOCALIZATION | Vesicles, NA, Nucleus, Cytosol, NA, Cytoplasm and nucleus, Unknown |
| N-TERMINAL MODIFICATION | Conjugation with fluorescein, Conjugation with fluorescein, Conjugated to Radiolabeled cytochrome c with disulphide linkage, Acetylation, Free, Conjugation with fluorescein, Free |
| C-TERMINAL MODIFICATION | Amidation, Amidation, NA, Amidation, Free, Amidation, Amidation |
| CHEMICAL MODIFICATION | NA, NA, NA, NA, NA, NA, NA |
| UPTAKE EFFICIENCY | NA, Lower uptake efficiency, 38-fold higher uptake for Cyt c-ss-MAP compared to unmodified Cyt c was observed, NA, NA, High (pmol internalized peptide/mg protein = 228), Unknown |
| PROPOSED UPTAKE MECHANISM | Non-endocytosis, Non endocytosis pathway, Endocytosis, NA, NA, Non-endocytic pathway, Unknown |
| INVITRO/INVIVO | In vivo, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro |
| CELL LINE | RBL-2H3 cells, CHO-K1, Rat basophilic leukemia RBL-2H3 cells and CHO-K1, HEK293 cells and HeLa cells, A549 and NIH3T3 cells, C166-eGFP cells, Aortic endothelial cells, 9 L/LacZ cells |
| In VIVO MODEL | NA, NA, NA, NA, NA, NA, NA |
| CARGO | Fluorophore (Fluorescein), Fluorophore (Fluorescein), Protein (Cyt C protein), Nucleic acid [Oligonucleotides (ODNs)], Nucleic acid (siRNA), Fluorophore (fluorescein), Nucleic acid (siRNA) |
| PMID | 25016968, 25016968, 22225540, 24216093, 10323198 |
| PATENT | Unknown, Unknown, Unknown, Unknown, WO 2011/020188 A1, Unknown, US 20060035815 |
| Tertiary Structure (Technique) | 2172 (PEPstrMOD), 2493 (PEPstrMOD), 2652 (PEPstrMOD), 2826 (PEPstrMOD), 2948 (PEPstrMOD), 1061 (PEPstrMOD), 1762 (PEPstrMOD), |