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Details of CPPsite entry with Sequence RRR
Primary information
PEPTIDE SEQUENCERRR
CPPsite ID 2680, 2685, 2686,
PEPTIDE NAMETMR-R3, EGFP-R3, p53-R3
CHIRALITYL, L, L
LINEAR/CYCLICLinear, Linear, Linear
SOURCESynthetic, Synthetic, Synthetic
CATEGORYCationic, Cationic, Cationic
SUB CELLULAR LOCALIZATIONCytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus
N-TERMINAL MODIFICATIONConjugation with TMR, Conjugation with EGFP, Conjugated to p53
C-TERMINAL MODIFICATIONNA, NA, NA
CHEMICAL MODIFICATIONNA, NA, NA
UPTAKE EFFICIENCYWith pyrenebutyrate, p53-3R was mainly observed in the Nucleus whereas without pyrenebutyrate, it existed in the Cytoplasm, NA, NA
PROPOSED UPTAKE MECHANISMlipid raft dependent macropinocytosis, NA, NA
INVITRO/INVIVOIn vitro, In vitro, In vitro
CELL LINEU251-MG, HeLa, HEK293 cells, LNZ308, K562 cells, Primary rat fibroblasts cells and U87 cells, U87MG, LNZ308, H520, K562 cells, U251-MG, LNZ308 cells
In VIVO MODELNA, NA, NA
CARGOFluorophore (TMR), Protein (eGFP), Protein (p53)
PMID22465335, 22465335, 22465335
PATENTUnknown, Unknown, Unknown
Tertiary Structure
(Technique)		2680 (PEPstrMOD), 2685 (PEPstrMOD), 2686 (PEPstrMOD),