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Page - 1 of 1 HIVsir ID HIV Strain NCBI Accession Target Gene Position of siRNA target Sense Sequence of siRNA Efficacy (%) Target Conservation * Cell line PubMed 1086 HIV-1 (NL4-3) AF324493 Vpu 6203 AAGAGCAGAAGACAGUGGCAA 95.00 849(56.75%) 293 T 15750613 1087 HIV-1(P89) K02013 Vpu 6211 AAGACAGUGGCAAUGAGAGUG 93.00 756(50.53%) 293 T 15750613 1088 HIV-1 (NL4-3) AF324493 Vpu 6211 AAGACAGUGGCAAUGAGAGUG 95.00 756(50.53%) 293 T 15750613 1486 HIV-1 (NL4-3) AF324493 Vpu 139 GAAAGAGCAGAAGACAGUGGC 85.00 840(56.15%) HEK 293a 19497094 1487 HIV-1 (NL4-3) AF324493 Vpu 140 AAAGAGCAGAAGACAGUGGC -56.00 841(56.22%) HEK 293a 19497094 1488 HIV-1 (NL4-3) AF324493 Vpu 140 AAAGAGCAGAAGACAGUGGCA 32.60 841(56.22%) HEK 293a 19497094 1489 HIV-1 (NL4-3) AF324493 Vpu 141 AAGAGCAGAAGACAGUGGCA 91.50 849(56.75%) HEK 293a 19497094 1490 HIV-1 (NL4-3) AF324493 Vpu 143 GAGCAGAAGACAGUGGCAAU 89.90 895(59.83%) HEK 293a 19497094 1491 HIV-1 (NL4-3) AF324493 Vpu 144 AGCAGAAGACAGUGGCAAUG 78.60 896(59.89%) HEK 293a 19497094 1492 HIV-1 (NL4-3) AF324493 Vpu 144 AGCAGAAGACAGUGGCAAUGA 86.00 892(59.63%) HEK 293a 19497094 1493 HIV-1 (NL4-3) AF324493 Vpu 145 GCAGAAGACAGUGGCAAUGA 92.30 917(61.30%) HEK 293a 19497094 1494 HIV-1 (NL4-3) AF324493 Vpu 146 CAGAAGACAGUGGCAAUGAG 88.30 801(53.54%) HEK 293a 19497094 1495 HIV-1 (NL4-3) AF324493 Vpu 147 AGAAGACAGUGGCAAUGAGAG 94.20 835(55.82%) HEK 293a 19497094 1496 HIV-1 (NL4-3) AF324493 Vpu 148 GAAGACAGUGGCAAUGAGAGU 91.80 757(50.60%) HEK 293a 19497094 1497 HIV-1 (NL4-3) AF324493 Vpu 149 AAGACAGUGGCAAUGAGAGU 89.70 758(50.67%) HEK 293a 19497094

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