| Purple | = Wild vs mutant target sequence along with mutation information |
| Brown | = Wild vs ASP-siRNA description along with positional differnece between two |
| Light pink | = ASP siRNA efficacy for mutant vs wild allele |
| Green | = Wild siRNA efficacy for Wild vs Mutant allele |
| siRNA Id: | aspsirna1791 |
| siRNA Name: | TTR-p8 |
| Gene: | Transthyretin (TTR) |
| Disease: | Amyloidogenic transthyretin amyloidosis |
| Wild allele/target (5'->3'): | UGUGGCCGUGCAUGUGUUC |
| Mutant allele/target (5'->3'): | UGUGGCCAUGCAUGUGUUC |
| Target Mutation: | c.148G>A,p.Val50Met |
| Wild siRNA (As strand): | ACACCGGCACGUACACAAG |
| ASP-siRNA (As strand): | ACACCGGUACGUACACAAG |
| Mismatch position in siRNA: | U12C |
| Mutant allele (5'->3'): | UGUGGCCAUGCAUGUGUUC |
| ASP-siRNA (As strand): | ACACCGGUACGUACACAAG |
| ASP-siRNA efficacy for mutant allele: | NA |
| Wild allele (5'->3'): | UGUGGCCGUGCAUGUGUUC |
| ASP-siRNA (As strand): | ACACCGGUACGUACACAAG |
| ASP-siRNA efficacy for wild allele: | 5 |
| Percentage discrimination for ASP-siRNA: | NA |
| Wild allele (5'->3'): | UGUGGCCGUGCAUGUGUUC |
| Wild siRNA (As strand): | ACACCGGCACGUACACAAG |
| Wild sirna efficacy for wild allele: | 67 |
| Wild allele (5'->3'): | UGUGGCCGUGCAUGUGUUC |
| ASP-siRNA (As strand): | ACACCGGUACGUACACAAG |
| Wild sirna efficacy for mutant allele: | NA |
| Percentage discrimination for wild siRNA: | NA |
| Concentration: | 20pMol |
| Orientation: | Sense |
| Mismatch in: | siRNA |
| UniProt ID: | P02766 |
| Target sequence: | GCCAUCAAUGUGGCCAUGCAUGUGUUCAGAAAG |
| Genbank Accesion: | NM_000371.3 |
| Cell-line: | Cos-7 |
| Experimental technique used: | Western blot |
| Transfection method: | Lipofectamine 2000 |
| siRNA expression method: | Qiagen |
| Post-transfection duration: | 48 hours |
| OMID ID: | 176300 |
| KEGG disease ID: | 105210 |
| Reference: | 16225852 |
| siRNA Id: | aspsirna1791 |
| siRNA Name: | siCD46 |
| Gene: | Complement regulatory protein (CD46) |
| Disease: | Hemolytic uremic syndrome |
| Wild allele/target (5'->3'): | CUUAUUGGAGAGAGCACGA |
| Mutant allele/target (5'->3'): | CUUUUUGGAGAGAGCACGA |
| Target Mutation: | c.104G>A, p.Cys35Tyr |
| Wild siRNA (As strand): | GAAUAACCUCUCUCGUGCU |
| ASP-siRNA (As strand): | GAAUAACCUCUCUCGUGCU |
| Mismatch position in siRNA: | U:U clash |
| Mutant allele (5'->3'): | CUUUUUGGAGAGAGCACGA |
| ASP-siRNA (As strand): | GAAUAACCUCUCUCGUGCU |
| ASP-siRNA efficacy for mutant allele: | 68 |
| Wild allele (5'->3'): | CUUAUUGGAGAGAGCACGA |
| ASP-siRNA (As strand): | GAAUAACCUCUCUCGUGCU |
| ASP-siRNA efficacy for wild allele: | 93 |
| Percentage discrimination for ASP-siRNA: | 25 |
| Wild allele (5'->3'): | CUUAUUGGAGAGAGCACGA |
| Wild siRNA (As strand): | GAAUAACCUCUCUCGUGCU |
| Wild sirna efficacy for wild allele: | 93 |
| Wild allele (5'->3'): | CUUAUUGGAGAGAGCACGA |
| ASP-siRNA (As strand): | GAAUAACCUCUCUCGUGCU |
| Wild sirna efficacy for mutant allele: | 68 |
| Percentage discrimination for wild siRNA: | 25 |
| Concentration: | 13nM |
| Orientation: | Sense |
| Mismatch in: | siRNA |
| UniProt ID: | P15529 |
| Target sequence: | GCCCCCAATATGTGAAAAG |
| Genbank Accesion: | NM_002389.4 |
| Cell-line: | HEK293 |
| Experimental technique used: | Dual luciferase reporter assay |
| Transfection method: | Lipofectamine 2000 |
| siRNA expression method: | Dharmacon |
| Post-transfection duration: | 24 hours |
| OMID ID: | 120920 |
| KEGG disease ID: | H00106, H0027 |
| Reference: | 15781493 |