| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| aspsirna1990 | UUUAUGAGGAUCUCUUUGA AAAUACUCCUAGAGAAACU |
30 | 30 | 0 | P. luciferase | NA | NA | NA | 
|
|
| aspsirna2415 | AACUCCUCCGCGCAAUUUU UUGAGGAGGCGCGUUAAAA |
46 | 70 | -24 | KRAS | NA | NA | NA |
|
|
| aspsirna3149 | CGCUGCUUUGAGGCCUGGA GCGACGAAACUCCGGACCU |
80 | 40 | 40 | TP63 | Ectrodactily-ectodermal dysplasia and cleft lip/palate (EEC) | c.727C>T, p.Arg243Trp | rs12190883 |
|
|
| aspsirna3157 | CGCUGCUUUGAGGCCUGGA GCGACGAAACUCCGGACCU |
81 | 38 | 43 | TP63 | Ectrodactily-ectodermal dysplasia and cleft lip/palate (EEC) | c.727C>T, p.Arg243Trp | rs12190883 |
|
|
| aspsirna3298 | AUCUACUGUGUGCACUUCAUC UAGAUGACACACGUGAAGUAG |
60 | 50 | 10 | HTT | Huntington disease (HD) | NM_002111.7:c.6931T>C | rs362331 |
|
|
| aspsirna3319 | CUGUGCCCUUGUGCCCUCCAC GACACGGGAACACGGGAGGUG |
57 | 22 | 35 | HTT | Huntington disease (HD) | NM_002111.6:c.9810C>T | rs362307 |
|
|
| aspsirna2230 | UUCAGCAGCAGCAGCAGUAGU AAGUCGUCGUCGUCGUCAUCU |
48 | 20 | 28 | ATN-1 | Dentatorubral-pallidoluysian atrophy (DRPLA) | c.1462_1464CAG(90_93) | rs19392293 |
|
|
| aspsirna3050 | CAGCUGUACACGGACUGCA GUCGACAUGUGCCUGACGU |
45 | 35 | 10 | TGFBI | Lattice corneal dystrophy type I (LCDI) | c.370C>T,p.Arg124Cys | rs12190921 |
|
|
| aspsirna0660 | CAGCAGCAGCAGCAGUAGC GUCGUCGUCGUCGUCAUCG |
20 | 13 | 7 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 |
|
|
| aspsirna0579 | CAGGAACUCAAUUCUUGGC GUCCUUGAGUUAAGAACCG |
5 | 0 | 5 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.487C>T,p.Arg163Trp | rs59616921 |
|
|
| aspsirna0617 | AAUGAGAAGAGCACCGUGC UUACUCUUCUCGUGGCACG |
55 | 68 | -13 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.469A>G ,p.Met157Val | rs58597584 |
|
|
| aspsirna3027 | CAGCAGCAGCAGCAGUAGC GUCGUCGUCGUCGUCAUCG |
60 | 40 | 20 | ATXN3 | Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) | c.892_894CAG(8_36) (p.Gln298_Gln305=) | rs19392292 |
|
|
| aspsirna0775 | CAGCAGCAGCAGCAGUAGC GUCGUCGUCGUCGUCAUCG |
45 | 20 | 25 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 |
|
|
| aspsirna0808 | GAGCCUUUGGAAGUCUGUGCA CUCGGAAACCUUCAGACACGU |
68 | 34 | 34 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs362307 |
|
|
| aspsirna0047 | GCCUGCUCCCUCAUCUACU CGGACGAGGGAGUAGAUGA |
90 | 70 | 20 | HTT | Huntington disease (HD) | c.6931T>C,c.52CAG(36_39) | rs362331 |
|
