| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| aspsirna3571 | AGUGGCUCACCAGAUUACA UCACCGAGUGGUCUAAUGU |
60 | 20 | 40 | ACVR1 | Fibrodysplasia Ossificans Progressiva (FOP) | c.617G>A,p.Arg206His | rs12191267 | 
|
|
| aspsirna2013 | UUUAUGAGAAUCUCUCUGA AAAUACUCUUAGAGAGACU |
45 | 30 | 15 | P. luciferase | NA | NA | NA |
|
|
| aspsirna3191 | GUUUCGACAUGUCCUUCCA CAAAGCUGUACAGGAAGGU |
90 | 25 | 65 | TP63 | Ectrodactyly-Ectodermal Dysplasia-Clefting syndrome 3 (EEC3) | p.Arg132His,c.394G>A | rs19392114 |
|
|
| aspsirna3082 | UGAGGUGCAUGUUUGUGCC ACUCCACGUACAAACACGG |
55 | 28 | 27 | TP53 | Cancer | NC_000005.10:g.144594367C>A | rs57315468 |
|
|
| aspsirna3088 | UGAGGUGCAUGUUUGUGCC ACUCCACGUACAAACACGG |
60 | 28 | 32 | TP53 | Cancer | NC_000005.10:g.144594367C>A | rs57315468 |
|
|
| aspsirna3094 | UGAGGUGCAUGUUUGUGCC ACUCCACGUACAAACACGG |
50 | 28 | 22 | TP53 | Cancer | NC_000005.10:g.144594367C>A | rs57315468 |
|
|
| aspsirna2182 | GAGAAGCCAGAGAUCCUGG CUCUUCGGUCUCUAGGACC |
50 | 5 | 45 | COL6A1 | Ullrich congenital muscular dystrophy (UCMD),Bethlem myopathy (BM) | c.850G>A, p.G284R | rs1219 |
|
|
| aspsirna1904 | UGUCACCCUCAGGUGAGGGUG ACAGUGGGAGUCCACUCCCAC |
Moderate efficacy | Moderate efficacy | Poor discrimination | Myh6 | Human hypertrophic cardiomyopathy (HCM) | c.2384G>A,p.Arg795Gln | rs26760690 |
|
|
| aspsirna0680 | CAGCAGCAGCAACAGCAGCAGC GUCGUCGUCGUUGUCGUCGUCG |
62 | 50 | 12 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 |
|
|
| aspsirna0605 | CAAUUCUCAGCUGGCCUCU GUUAAGAGUCGACCGGAGA |
38 | 35 | 3 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.488G>A,p.Arg163Gln | rs57758262 |
|
|
| aspsirna0324 | UGGUAUUCCCAGGCUCCCA ACCAUAAGGGUCCGAGGGU |
40 | 20 | 20 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0367 | AGUGGCUCACCAGAUUACA UCACCGAGUGGUCUAAUGU |
60 | 30 | 30 | ACVR1 | Fibrodysplasia Ossificans Progressiva (FOP) | c.617G>A,p.Arg206His | rs12191267 |
|
|
| aspsirna0380 | AGAUUUGGACCUGGCAGUC UCUAAACCUGGACCGUCAG |
NA | NA | NA | ACVR1 | Fibrodysplasia Ossificans Progressiva (FOP) | c.1067G>A,p.Gly356Asp | rs12191267 |
|
|
| aspsirna0422 | AGAUUUGGACCUGGCAGUCAU UCUAAACCUGGACCGUCAG |
NA | NA | NA | ACVR1 | Fibrodysplasia Ossificans Progressiva (FOP) | c.1067G>A,p.Gly356Asp | rs12191267 |
|
|
| aspsirna0423 | AGAUUUGGACCUGGCAGUCA UCUAAACCUGGACCGUCAG |
52 | 0 | 52 | ACVR1 | Fibrodysplasia Ossificans Progressiva (FOP) | c.1067G>A,p.Gly356Asp | rs12191267 |
|
|
| aspsirna0424 | AGAUUUGGACCUGGCAGU UCUAAACCUGGACCGUCAG |
0 | 0 | 0 | ACVR1 | Fibrodysplasia Ossificans Progressiva (FOP) | c.1067G>A,p.Gly356Asp | rs12191267 |
|
|
| aspsirna0425 | GAUUUGGACCUGGCAGUC UCUAAACCUGGACCGUCAG |
82 | 42 | 40 | ACVR1 | Fibrodysplasia Ossificans Progressiva (FOP) | c.1067G>A,p.Gly356Asp | rs12191267 |
|
|
| aspsirna0426 | CAGAUUUGGACCUGGCAGUC UCUAAACCUGGACCGUCAG |
85 | 48 | 37 | ACVR1 | Fibrodysplasia Ossificans Progressiva (FOP) | c.1067G>A,p.Gly356Asp | rs12191267 |
|
|
| aspsirna0427 | GCAGAUUUGGACCUGGCAGUC UCUAAACCUGGACCGUCAG |
75 | 72 | 3 | ACVR1 | Fibrodysplasia Ossificans Progressiva (FOP) | c.1067G>A,p.Gly356Asp | rs12191267 |
|
|
| aspsirna0251 | CUGACUACAGCAUUGCUCA GACUGAUGUCGUAACGAGU |
60 | 40 | 20 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna0857 | UGCCAGCCAUGAACAAUGU ACGGUCGGUACUUGUUACA |
77 | 60 | 17 | ATXN7 | Spino Cerebellar Ataxia type-7 (SCA-7) | c.88_90CAG(7_17) | rs193922929 |
|
|
| aspsirna0066 | CAGUGAUCAUCAUCACCUU GUCACUAGUAGUAGUGGAA |
36 | 63 | -27 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0124 | UUGUGCACAACUGCGUCAA AACACGUGUUGACGCAGUU |
70 | 89 | -19 | PRNP | Prion disease/Creutzfeldt-Jakob disease | c.532G>A,p.Asp178Asn | rs74315403 |
|
|
| aspsirna0160 | UUGUGCACAACUGCGUCAA AACACGUGUUGACGCAGUU |
70 | 89 | -19 | PRNP | Prion disease/Creutzfeldt-Jakob disease | c.532G>A,p.Asp178Asn | rs74315403 |
|
|
| aspsirna0886 | ACCCUCAAAAACAAGUUUG UGGGAGUUUUUGUUCAAAC |
13 | 0 | 13 | KRT6a | Pachyonychia congenita (PC) | c.513C>A,p.Asn171Lys | rs59685571 |
|
|
| aspsirna3696 | GGUUGGAGGAGAGAUGAUA CCAACCUCUUCUCUACUAU |
90 | 35 | 55 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
|
| aspsirna3773 | AAAGUUGCGCGGAGGAGUU UUUCAACGUGCCUCCUCAA |
90 | 61 | 29 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
|
| aspsirna0527 | GCAUGGUGUGACAACAGUGGC CGUACCACACUGUUGUCACCG |
10 | 50 | -40 | SNCA | Parkinsons disease (PD) | c.157G>A,p.Ala53Thr | rs10489387 |
|
|
| aspsirna0536 | GCAUGGUGUGACAACAGUGGC CGUACCACACUGUUGUCACCG |
10 | 50 | -40 | SNCA | Parkinsons disease (PD) | c.157G>A,p.Ala53Thr | rs10489387 |
|
|
| aspsirna0569 | GACAGUGAUCAUCAUCACCUU CUGUCACUAGUAGUAGUGGAA |
64 | 67 | -3 | APP | Alzheimers disease | c.2149G>A,p.Val717Ile | rs63750264 |
|
