| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| aspsirna3569 | UGGCUCACCAGAUUACACU ACCGAGUGGUCUAAUGUGA |
60 | 20 | 40 | ACVR1 | Fibrodysplasia Ossificans Progressiva (FOP) | c.617G>A,p.Arg206His | rs12191267 | 
|
|
| aspsirna3193 | UUCGACAUGUCCUUCCAGC AAGCUGUACAGGAAGGUCG |
92 | 5 | 87 | TP63 | Ectrodactyly-Ectodermal Dysplasia-Clefting syndrome 3 (EEC3) | p.Arg132His,c.394G>A | rs19392114 |
|
|
| aspsirna3100 | UGAGGCACUGCCCCCACCA ACUCCGUGACGGGGGUGGU |
58 | 28 | 30 | TP53 | Cancer | c.524G>A ,p.Arg175His | rs28934578 |
|
|
| aspsirna3107 | UGAGGCACUGCCCCCACCA ACUCCGUGACGGGGGUGGU |
58 | 28 | 30 | TP53 | Cancer | c.524G>A ,p.Arg175His | rs28934578 |
|
|
| aspsirna2180 | GAAGCCAGAGAUCCUGGAA CUUCGGUCUCUAGGACCUU |
60 | 10 | 50 | COL6A1 | Ullrich congenital muscular dystrophy (UCMD),Bethlem myopathy (BM) | c.850G>A, p.G284R | rs1219 |
|
|
| aspsirna1906 | UCACCCUCAGGUGAGGGUGGG AGUGGGAGUCCACUCCCACCC |
Moderate efficacy | Moderate efficacy | Poor discrimination | Myh6 | Human hypertrophic cardiomyopathy (HCM) | c.2384G>A,p.Arg795Gln | rs26760690 |
|
|
| aspsirna0607 | AUUCUCAGCUGGCCUCUUA UAAGAGUCGACCGGAGAAU |
4 | 0 | 4 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.488G>A,p.Arg163Gln | rs57758262 |
|
|
| aspsirna0322 | CCUGGUAUUCCCAGGCUCC GGACCAUAAGGGUCCGAGG |
50 | 20 | 30 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0253 | GACUACAGCAUUGCUCAGU CUGAUGUCGUAACGAGUCA |
60 | 45 | 15 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna0859 | CCAGCCAUGAACAAUGUCC GGUCGGUACUUGUUACAGG |
NA | 50 | NA | ATXN7 | Spino Cerebellar Ataxia type-7 (SCA-7) | c.88_90CAG(7_17) | rs193922929 |
|
|
| aspsirna0089 | GUGCACAACUGCGUCAAUA CACGUGUUGACGCAGUUAU |
82 | 95 | -13 | PRNP | Prion disease/Creutzfeldt-Jakob disease | c.532G>A,p.Asp178Asn | rs74315403 |
|
|
| aspsirna3504 | GUGCACAACUGCGUCAAUA CACGUGUUGACGCAGUUAU |
82 | 95 | -13 | PRNP | Prion disease/Creutzfeldt-Jakob disease | c.532G>A,p.Asp178Asn | rs74315403 |
|
|
| aspsirna0888 | CCUCAAAAACAAGUUUGCC GGAGUUUUUGUUCAAACGG |
45 | 9 | 36 | KRT6a | Pachyonychia congenita (PC) | c.513C>A,p.Asn171Lys | rs59685571 |
|
|
| aspsirna3781 | AAAGUUGCGCGGAGGAGUU UUUCAAUGCGCCUCCUCAA |
90 | 20 | 70 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
|
| aspsirna0525 | AUGGUGUGACAACAGUGGCUG UACCACACUGUUGUCACCGAC |
39 | 20 | 19 | SNCA | Parkinsons disease (PD) | c.157G>A,p.Ala53Thr | rs10489387 |
|
|
| aspsirna0530 | AUGGUGUGACAACAGUGGCUG UACCACACUGUUGUCACCGAC |
39 | 20 | 19 | SNCA | Parkinsons disease (PD) | c.157G>A,p.Ala53Thr | rs10489387 |
|
|
| aspsirna0531 | AUGGUGUGACAACAGUGGCUG UACCACACUGUUGUCACCGAC |
55 | 39 | 16 | SNCA | Parkinsons disease (PD) | c.157G>A,p.Ala53Thr | rs10489387 |
|
|
| aspsirna0534 | AUGGUGUGACAACAGUGGCUG UACCACACUGUUGUCACCGAC |
39 | 25 | 14 | SNCA | Parkinsons disease (PD) | c.157G>A,p.Ala53Thr | rs10489387 |
|
|
| aspsirna0539 | AUGGUGUGACAACAGUGGCUG UACCACACUGUUGUCACCGAC |
55 | 40 | 15 | SNCA | Parkinsons disease (PD) | c.157G>A,p.Ala53Thr | rs10489387 |
|
|
| aspsirna0571 | CAGUGAUCAUCAUCACCUUGG GUCACUAGUAGUAGUGGAACC |
38 | 77 | -39 | APP | Alzheimers disease | c.2149G>A,p.Val717Ile | rs63750264 |
|
|
| aspsirna1790 | GUGGCCAUGCAUGUGUUCA CACCGGUACGUACACAAGU |
NA | 5 | NA | TTR | Amyloidogenic transthyretin amyloidosis | c.148G>A,p.Val50Met | rs28933979 |
|
