| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| aspsirna3195 | CGACAUGUCCUUCCAGCAG GCUGUACAGGAAGGUCGUC |
38 | 20 | 18 | TP63 | Ectrodactyly-Ectodermal Dysplasia-Clefting syndrome 3 (EEC3) | p.Arg132His,c.394G>A | rs19392114 | 
|
|
| aspsirna3098 | AGGCACUGCCCCCACCAUG UCCGUGACGGGGGUGGUAC |
60 | 45 | 15 | TP53 | Cancer | c.524G>A ,p.Arg175His | rs28934578 |
|
|
| aspsirna3105 | AGGCACUGCCCCCACCAUG UCCGUGACGGGGGUGGUAC |
60 | 45 | 15 | TP53 | Cancer | c.524G>A ,p.Arg175His | rs28934578 |
|
|
| aspsirna1908 | ACCCUCAGGUGAGGGUGGGGA UGGGAGUCCACUCCCACCCCU |
Moderate efficacy | Moderate efficacy | Poor discrimination | Myh6 | Human hypertrophic cardiomyopathy (HCM) | c.2384G>A,p.Arg795Gln | rs26760690 |
|
|
| aspsirna0609 | UCUCAGCUGGCCUCUUACU AGAGUCGACCGGAGAAUGA |
76 | 20 | 56 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.488G>A,p.Arg163Gln | rs57758262 |
|
|
| aspsirna0320 | AGCCUGGUAUUCCCAGGCU UCGGACCAUAAGGGUCCGA |
82 | 15 | 67 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0255 | CUACAGCAUUGCUCAGUAC GAUGUCGUAACGAGUCAUG |
80 | 60 | 20 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna0545 | CUACAGCAUUGCUCAGUAC GAUGUCGUAACGAGUCAUG |
29 | 4 | 25 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna0861 | AGCCAUGAACAAUGUCCAC UCGGUACUUGUUACAGGUG |
NA | 78 | NA | ATXN7 | Spino Cerebellar Ataxia type-7 (SCA-7) | c.88_90CAG(7_17) | rs193922929 |
|
|
| aspsirna0890 | UCAAAAACAAGUUUGCCUC AGUUUUUGUUCAAACGGAG |
45 | 10 | 35 | KRT6a | Pachyonychia congenita (PC) | c.513C>A,p.Asn171Lys | rs59685571 |
|
|
| aspsirna3712 | GGUUGGAGGAGAGAUGAUA CCAAUCUCCUCUCUACUAU |
90 | 54 | 36 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
