| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| aspsirna3196 | GACAUGUCCUUCCAGCAGU CUGUACAGGAAGGUCGUCA |
10 | 20 | -10 | TP63 | Ectrodactyly-Ectodermal Dysplasia-Clefting syndrome 3 (EEC3) | p.Arg132His,c.394G>A | rs19392114 | 
|
|
| aspsirna3099 | AGGCACUGCCCCCACCAUGA UCCGUGACGGGGGUGGUACU |
78 | 20 | 58 | TP53 | Cancer | c.524G>A ,p.Arg175His | rs28934578 |
|
|
| aspsirna3106 | AGGCACUGCCCCCACCAUGA UCCGUGACGGGGGUGGUACU |
80 | 20 | 60 | TP53 | Cancer | c.524G>A ,p.Arg175His | rs28934578 |
|
|
| aspsirna1909 | CCCUCAGGUGAGGGUGGGGAC GGGAGUCCACUCCCACCCCUG |
78 | 70 | 8 | Myh6 | Human hypertrophic cardiomyopathy (HCM) | c.2384G>A,p.Arg795Gln | rs26760690 |
|
|
| aspsirna1913 | CCCUCAGGUGAGGGUGGGGAC GGGAGUCCACUCCCACCCCUG |
78 | 70 | 8 | Myh6 | Human hypertrophic cardiomyopathy (HCM) | c.2384G>A,p.Arg795Gln | rs26760690 |
|
|
| aspsirna0610 | CUCAGCUGGCCUCUUACUU GAGUCGACCGGAGAAUGAA |
24 | 8 | 16 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.488G>A,p.Arg163Gln | rs57758262 |
|
|
| aspsirna0319 | AAGCCUGGUAUUCCCAGGC UUCGGACCAUAAGGGUCCG |
30 | 21 | 9 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0339 | CCCAGGCUCCCAGGCAGGG GGGUCCGAGGGUCCGUCCC |
57 | 67 | -10 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0256 | UACAGCAUUGCUCAGUACU AUGUCGUAACGAGUCAUGA |
50 | 40 | 10 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna0546 | UACAGCAUUGCUCAGUACU AUGUCGUAACGAGUCAUGA |
46 | 14 | 32 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna0862 | GCCAUGAACAAUGUCCACA CGGUACUUGUUACAGGUGU |
NA | 60 | NA | ATXN7 | Spino Cerebellar Ataxia type-7 (SCA-7) | c.88_90CAG(7_17) | rs193922929 |
|
|
| aspsirna0843 | CUGCUACAGAUCAACCCCGAG GACGAUGUCUAGUUGGGGCUC |
NA | NA | NA | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs362273 |
|
|
| aspsirna0058 | GCUAAUGUAUGUGACGCUG CGAUUACAUACACUGCGAC |
92 | 58 | 34 | HTT | Huntington disease (HD) | c.8163G>A,c.52CAG(36_39) | rs2276881 |
|
|
| aspsirna0891 | CAAAAACAAGUUUGCCUCC GUUUUUGUUCAAACGGAGG |
23 | 20 | 3 | KRT6a | Pachyonychia congenita (PC) | c.513C>A,p.Asn171Lys | rs59685571 |
|
|
| aspsirna3640 | UCAGAGAGAUCCUCAUAAA AGUUUCUCUAGGAGUAUUU |
90 | 30 | 60 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
|
| aspsirna3793 | AAAGUUGCGCGGAGGAGUU UUUUAACGCGCCUCCUCAA |
90 | 46 | 44 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
|
| aspsirna1789 | GCCAUGCAUGUGUUCAGAA CGGUACGUACACAAGUCUU |
NA | 20 | NA | TTR | Amyloidogenic transthyretin amyloidosis | c.148G>A,p.Val50Met | rs28933979 |
|
|
| aspsirna1823 | AAGCAACACAAUGAUGAGUGC UUCGUUGUGUUACUACUCACG |
NA | 55 | NA | Fen1 | Werner syndrome | NA | NA |
|
