| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| aspsirna3198 | CAUGUCCUUCCAGCAGUCG GUACAGGAAGGUCGUCAGC |
60 | 30 | 30 | TP63 | Ectrodactyly-Ectodermal Dysplasia-Clefting syndrome 3 (EEC3) | p.Arg132His,c.394G>A | rs19392114 | 
|
|
| aspsirna1911 | CUCAGGUGAGGGUGGGGACCG GAGUCCACUCCCACCCCUGGC |
Moderate efficacy | Moderate efficacy | Poor discrimination | Myh6 | Human hypertrophic cardiomyopathy (HCM) | c.2384G>A,p.Arg795Gln | rs26760690 |
|
|
| aspsirna0612 | CAGCUGGCCUCUUACUUGG GUCGACCGGAGAAUGAACC |
56 | 39 | 17 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.488G>A,p.Arg163Gln | rs57758262 |
|
|
| aspsirna0317 | GAAAGCCUGGUAUUCCCAG CUUUCGGACCAUAAGGGUC |
58 | 33 | 25 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0853 | CAGCGGCGGCAGTGGCGGC GUCGCCGCCGUCTCCGCCG |
70 | 40 | 30 | KRAS | Pancreatic cancer | c.36G>A,p.Gly12Asp | rs12191352 |
|
|
| aspsirna0855 | CAGCGGCGGCAGTGGCGGC GUCGCCGCCGUCTCCGCCG |
70 | 44 | 26 | KRAS | Pancreatic cancer | c.36G>A,p.Gly12Asp | rs12191352 |
|
|
| aspsirna0893 | AAAACAAGUUUGCCUCCUU UUUUGUUCAAACGGAGGAA |
47 | 20 | 27 | KRT6a | Pachyonychia congenita (PC) | c.513C>A,p.Asn171Lys | rs59685571 |
|
|
| aspsirna3724 | GGUUGGAGGAGAGAUGAUA CUAACCUCCUCUCUACUAU |
90 | 92 | -2 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
