| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| aspsirna3199 | AUGUCCUUCCAGCAGUCGA UACAGGAAGGUCGUCAGCU |
40 | 40 | 0 | TP63 | Ectrodactyly-Ectodermal Dysplasia-Clefting syndrome 3 (EEC3) | p.Arg132His,c.394G>A | rs19392114 | 
|
|
| aspsirna1912 | UCAGGUGAGGGUGGGGACCGA AGUCCACUCCCACCCCUGGCU |
Moderate efficacy | Moderate efficacy | Poor discrimination | Myh6 | Human hypertrophic cardiomyopathy (HCM) | c.2384G>A,p.Arg795Gln | rs26760690 |
|
|
| aspsirna0613 | AGCUGGCCUCUUACUUGGA UCGACCGGAGAAUGAACCU |
81 | 23 | 58 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.488G>A,p.Arg163Gln | rs57758262 |
|
|
| aspsirna0316 | GGAAAGCCUGGUAUUCCCA CCUUUCGGACCAUAAGGGU |
80 | 28 | 52 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0852 | AGCGGCGGCAGTGGCGGCGGC UCGCCGCCGUCTCCGCCGCCG |
65 | 20 | 45 | KRAS | Pancreatic cancer | c.36G>A,p.Gly12Asp | rs12191352 |
|
|
| aspsirna0854 | AGCGGCGGCAGTGGCGGCGGC UCGCCGCCGUCTCCGCCGCCG |
65 | 25 | 40 | KRAS | Pancreatic cancer | c.36G>A,p.Gly12Asp | rs12191352 |
|
|
| aspsirna0894 | AAACAAGUUUGCCUCCUUC UUUGUUCAAACGGAGGAAG |
34 | 9 | 25 | KRT6a | Pachyonychia congenita (PC) | c.513C>A,p.Asn171Lys | rs59685571 |
|
|
| aspsirna3728 | GGUUGGAGGAGAGAUGAUA UCAACCUCCUCUCUACUAU |
90 | 93 | -3 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
|
| aspsirna1824 | AAACAGCACAAUGAUGAGUGC UUUGUCGUGUUACUACUCACG |
NA | 75 | NA | Fen1 | Werner syndrome | NA | NA |
|
