| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| aspsirna3186 | GCACAGUUUCGACAUGUCC CGUGUCAAAGCUGUACAGG |
80 | 40 | 40 | TP63 | Ectrodactyly-Ectodermal Dysplasia-Clefting syndrome 3 (EEC3) | p.Arg132His,c.394G>A | rs19392114 | 
|
|
| aspsirna1899 | GCCUGUGUCACCCUCAGGUGA CGGACACAGUGGGAGUCCACU |
Moderate efficacy | Moderate efficacy | Poor discrimination | Myh6 | Human hypertrophic cardiomyopathy (HCM) | c.2384G>A,p.Arg795Gln | rs26760690 |
|
|
| aspsirna0600 | GAACUCAAUUCUCAGCUGG CUUGAGUUAAGAGUCGACC |
49 | 0 | 49 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.488G>A,p.Arg163Gln | rs57758262 |
|
|
| aspsirna0329 | UUCCCAGGCUCCCAGGCAG AAGGGUCCGAGGGUCCGUC |
30 | 20 | 10 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0246 | GAUUGCUGACUACAGCAUU CUAACGACUGAUGUCGUAA |
13 | 59 | -46 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna0881 | UCAAGACCCUCAAAAACAA AGUUCUGGGAGUUUUUGUU |
89 | 10 | 79 | KRT6a | Pachyonychia congenita (PC) | c.513C>A,p.Asn171Lys | rs59685571 |
|
|
| aspsirna3753 | AAAGUUGCGCGGAGGAGUU UUUCAACGCGCCUUCUCAA |
90 | 8 | 82 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
|
| aspsirna1794 | UCAAUGUGGCCAUGCAUGU AGUUACACCGGUACGUACA |
NA | 15 | NA | TTR | Familial amyloidotic polyneuropathy (FAP) | c.148G>A,p.Val50Met | rs28933979 |
|
|
| aspsirna1821 | AAGCAGCACAAUGAUAAGUGC UUCGUCGUGUUACUAUUCACG |
NA | 22 | NA | Fen1 | Werner syndrome | NA | NA |
|
