aspsirna0979 details

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ASPsiRNA information siRNA Id:aspsirna0979
siRNA Name: d9
Mismatch information Wild siRNA (As strand 3'->5'):NA
ASP-siRNA (As strand 3'->5'):GUCGUCGUCGUCGUCGUCGUCGUCGUC
Mismatch position in siRNA: NA
Gene Information Gene Name Ataxin-3 (ATXN3)
Target Sequence (5'->3'):AGCAGCAAAAGCAGCAACAGCAGCAGCAGCAG
Wild allele (5'->3'):NA
Mutant allele (5'->3'):CAGCAGCAGCAGCAGCAGCAGCAGCAG
Position of siRNA on target gene: 278-298
Respective Gene/Protein Resources GenBank Accession:NM_001164774.1
Cytogenic location:14q32.12  
Chromosomal coordinates:14:92,524,895-92,572,964
UniProt ID:P54252
HUGO ID:7106
Reference SNp(RefSNP): rs19392292
Disease/Mutation information Target Mutation: c.209_211CAG(8_36),(p.Gln298_Gln305=)
Matation type/variant: Microsatellite/synonymous variant
Mutation at gene level: NG_008198.2:g.40588_40590CAG(8_36)
Pathogenic status of mutation: Risk factor
Disease:Parkinsons disease (PD)
Clinical Resources ClinVar ID:3551
KEGG disease ID:H00056
OMIM ID: 168600
COSMIC: ATXN3
DECIPHER: ATXN3
GeneTests: ATXN3
ASP siRNA details Mutant allele (5'->3'): CAGCAGCAGCAGCAGCAGCAGCAGCAG
ASP-siRNA (As strand 3'->5'):GUCGUCGUCGUCGUCGUCGUCGUCGUC
Percentage efficacy of ASP-siRNA for mutant allele:78
Wild allele (5'->3'): NA
ASP-siRNA (As strand 3'->5'):GUCGUCGUCGUCGUCGUCGUCGUCGUC
Percentage efficacy of ASP-siRNA for wild allele:30
Relative difference:48
Wild siRNA details Wild allele (5'->3'): NA
Wild siRNA (As strand 3'->5'):NA
Percentage efficacy of wild siRNA for wild allele:NA
Wild allele (5'->3'): NA
ASP-siRNA (As strand 3'->5'):GUCGUCGUCGUCGUCGUCGUCGUCGUC
Percentage efficacy of Wild sirna for mutant allele:NA
Relative difference :NA
General information Mismatch incorporated in siRNA/Target:siRNA
Cell-line used: Fibroblast
Experimental technique used: RT-PCR
Transfection method: Lipofectamine 2000
siRNA expression method: Metabion
Post-transfection duration: 24 hours
Concentration used:20nM
Reference:21427085
Delivery method:Transfection
Article title:Inhibition of mutant huntingtin expression by RNA duplex targeting expanded CAG repeats.
Authors:Fiszer A, Mykowska A, Krzyzosiak WJ.
Journal Reference:Nucleic Acids Res. 2011 Jul;39(13):5578-85. doi: 10.1093/nar/gkr156. Epub 2011 Mar 22.