VIRsiRNAdb is a curated database of experimentally validated viral siRNA/shRNA targeting diverse genes of 42 important human viruses including influenza, SARS and Hepatitis viruses.
Currently database provides detailed experimental information of 1358 siRNA/shRNA which includes siRNA sequence, virus subtype, target gene, GenBank accession, design algorithm, cell type, test object, test method and efficacy (mostly quantitative efficacies).
Further, wherever available, information regarding alternative efficacies of above 300 siRNAs derived from different assays has also been incorporated.
Database has facilities like search, advance search (using Boolean operators AND, OR) browsing (with data sorting option), internal linking and external linking to other databases (Pubmed, Genbank, ICTV).
Additionally useful siRNA analysis tools are also provided e.g. siTarAlign for aligning the siRNA sequence with reference viral genomes or user defined sequences.
VIRsiRNAdb would prove useful for RNAi researchers especially in siRNA based antiviral therapeutics development.
Thakur Nishant, Qureshi Abid, Kumar Manoj*; VIRsiRNAdb: a curated database of experimentally validated viral siRNA/shRNA.
Nucleic Acids Res. 2012 Jan;40(1):D230-6 10.1093/nar/gkr1147.
:Viral siRNA prediction algorithm
Bioinformatics Centre, Institute of Microbial Technology, Chandigarh-160036, India