• VIRsiRNAdb is a curated database of experimentally validated viral siRNA/shRNA targeting diverse genes of 42 important human viruses including influenza, SARS and Hepatitis viruses.

  • Currently database provides detailed experimental information of 1358 siRNA/shRNA which includes siRNA sequence, virus subtype, target gene, GenBank accession, design algorithm, cell type, test object, test method and efficacy (mostly quantitative efficacies).

  • Further, wherever available, information regarding alternative efficacies of above 300 siRNAs derived from different assays has also been incorporated.

  • Database has facilities like search, advance search (using Boolean operators AND, OR) browsing (with data sorting option), internal linking and external linking to other databases (Pubmed, Genbank, ICTV).

  • Additionally useful siRNA analysis tools are also provided e.g. siTarAlign for aligning the siRNA sequence with reference viral genomes or user defined sequences.

  • VIRsiRNAdb would prove useful for RNAi researchers especially in siRNA based antiviral therapeutics development.

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    Reference:

    Thakur Nishant, Qureshi Abid, Kumar Manoj*; VIRsiRNAdb: a curated database of experimentally validated viral siRNA/shRNA.
Nucleic Acids Res. 2012 Jan;40(1):D230-6 10.1093/nar/gkr1147.

    Related:

    VIRsiRNApred:Viral siRNA prediction algorithm


    Bioinformatics Centre, Institute of Microbial Technology, Chandigarh-160036, India

    Bioinformatics centre

    Institute of Microbial Technology, Chandigarh, India