AHTpin: Designing of Antihypetensive peptides


Antihypertensive Peptide Inhibitors

Updated version at IIIT Delhi

*** Reference: Kumar et. al. (2015) An in silico platform for predicting, screening and designing of antihypertensive peptides. Sci. Rep. 5, 12512.

Updated version at IIIT Delhi

Welcome to Home Page of AHTpin

AHTpin is an in silico method developed to predict and design efficient antihypertensive peptides. Following are the major features of AHTpin:-

Design of AHT peptides: This module generates all possible mutant (single amino acid at a time) and predicts antihypertensive property of each peptide. This way user may select best antihypertensive mutant peptide.

Virtual screening or Batch submission: This module of AHTpin allows the user to submit large number of peptides and select best antihypertensive peptides from library of peptides.

  • Protein scanning or mapping: This module scans whole protein submitted by the user using overlapping approach and predicts antihypertensive peptides in protein. In simple words it identify or map antihypertensive regions in a protein.

  • Propensity Matrix (PM): This matrix provides propensity of each type of residue at each position. Thus user can select desired amino acid at a given position of peptide in order to increase of decrease antihypertensive potential of that peptide.

  • Physicochemical Property: One of the major features of AHTpin is that it also calculates various physicochemical properties. Peptide analogs can be displayed in sorting order based upon desired properties.