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Details of CPPsite entry with Sequence VSRRRRRRGGRRRR
Primary information
PEPTIDE SEQUENCEVSRRRRRRGGRRRR
CPPsite ID 2170, 2306, 2470, 2612, 2782, 2821,
PEPTIDE NAMEC24-LMWP, LMWP, C24-LMWP, LMWP-TAZ, lowmolecular weight protamine (LMWP), low molecular weight protamine (LMWP)
CHIRALITYL, L, L, L, L, L
LINEAR/CYCLICLinear, Linear, Linear, Linear, Linear, Linear
SOURCEProtein derived, Synthetic, Protein derived, Synthetic, Synthetic, Chimeric
CATEGORYCationic, NA, Cationic, Cationic, Cationic, Cationic
SUB CELLULAR LOCALIZATIONNA, Cytoplasm and Nucleus, Nucleus, Cytoplasm and Nucleus, NA, NA
N-TERMINAL MODIFICATIONC24 chain composed of two 12-aminododecanoic acid (ADA) added at N terminal, Free, Free, NA, Free, Sulfhydrylation
C-TERMINAL MODIFICATIONNA, Free, Free, NA, Free, Free
CHEMICAL MODIFICATIONNA, NA, NA, NA, NA, Sulfhydrylation
UPTAKE EFFICIENCYHigher uptake efficiency, Higher uptake efficency, Higher uptake efficiency, High, NA, Equivalent cell-internalization potency to that of TAT
PROPOSED UPTAKE MECHANISMNA, NA, Endocytic pathway, NA, NA, NA
INVITRO/INVIVOIn vitro and in vivo, In vitro and in vivo, In vitro and in vivo, In vitro, In vitro, In vitro and in vivo
CELL LINEA549, A549/T,MCF-7,MCF-7/ADR, Pluripotent mouse mesenchymal progenitor cell line (C3H10T1/2), A549/T and MCF-7/ADR, Cultured Human Dental Pulp Stem Cells (hDPSCs), hMSC, Caco-2 cell culture
In VIVO MODELMice, New Zealand White male rabbits, BALB/c-nu nude mice, NA, NA, Male Wistar rats
CARGONanoparticle (PLGA-NPs), Protein [PDZ-binding motif (TAZ)], Nanoparticle (LMWP/PLGA nanoparticles), Small molecule drug (Doxorubicin), Protein [TAZ (transcriptional co-activator with PDZ-binding motif)], Nucleic acid (miRNA), Protein (Insulin-PEG-LMWP)
PMID25003794, 24648725, 25003794, 21990606, 23478036, 23863452
PATENTUnknown, Unknown, Unknown, Unknown, Unknown, Unknown
Tertiary Structure
(Technique)		2170 (PEPstrMOD), 2306 (PEPstrMOD), 2470 (PEPstrMOD), 2612 (PEPstrMOD), 2782 (PEPstrMOD), 2821 (PEPstrMOD),