==== Reference: Usmani SS, Bedi G, Samuel JS, Singh S, Kalra S, Kumar P, et al. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLoS ONE 12(7) e0181748.====

Detailed description page of THPdb

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1449 details
Primary information
ThPP IDTh1081
Therapeutic Peptide/Protein NameAntithymocyte globulin
SequenceN.A. view full sequnce in fasta
Functional ClassificationIIa
Molecular WeightN.A.
Chemical FormulaN.A.
Isoelectric PointN.A.
HydrophobicityN.A.
Melting Point (℃)61 (FAB fr
Half Life2-3 days
DescriptionPolyclonal rabbit anti-thymocyte globulin. Used to suppresses certain types of immune cells ascribed to acute organ rejection in transplant patients by selective depletion of T-cells.
Indication/DiseaseFor prevention of renal transplant rejection
PharmacodynamicsAntithymocyte Globulin (ATG)is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits after immunization with a T-lympoblast cell line. ATG is an immunosuppressive product for the prevention and treatment of acute rejection following organ transplantation. ATG reduces the host immune response against tissue transplants or organ allografts.
Mechanism of ActionBinds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis.
ToxicityN.A.
MetabolismMost likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production.
AbsorptionN.A.
Volume of DistributionN.A.
ClearanceN.A.
CategoriesImmunologic Factors and Immunosuppressive Agents
Patents NumberN.A.
Date of IssueN.A.
Date of ExpiryN.A.
Drug InteractionCanakinumab results in increased immunosuppressive effects; increases the risk of infection
TargetN.A.
Information of corresponding available drug in the market
Brand NameAntithymocyte globulin
CompanyPfizer
Brand DiscriptionTreating acute kidney transplant rejection with other medicines used to suppress the immune system. It may also be used for other conditions as determined by your doctor. Anti-thymocyte globulin (rabbit) is an immune globulin. It works by suppressing the body's immune response, but the way it does this is not fully understood.
Prescribed forN.A.
Chemical NameN.A.
FormulationPowder for injection 25 mg vials
Physcial AppearnceN.A.
Route of AdministrationIntravenous infusion
Recommended DosageUsual Adult Dose for Renal Transplant: 1.5 mg/kg/day by IV infusion for 7 to 14 days. Anti-thymocyte globulin (rabbit) should be infused over a minimum of 6 hours for the first infusion and over at least 4 hours on subsequent days of therapy. Premedication with corticosteroids, acetaminophen, and/or an antihistamine 1 hour prior to the infusion is recommended and may reduce the incidence and intensity of side effects during the infusion.
ContraindicationAcute viral illness; hypersensitivity to leporine proteins; previous hypersensitivity to anti-thymocyte globulin.
Side EffectsN.A.
Useful LinkN.A.
PubMed ID25598277, 25588925, 25583265, 25563075, 25539464, 25536216, 12160363
3-D StructureN.A.