Detailed description page of THPdb

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1460 details

Primary information
ThPP ID	Th1087
Therapeutic Peptide/Protein Name	Oxytocin
Sequence	CYIQNCPLG view full sequnce in fasta
Functional Classification	Ib
Molecular Weight	1007.187
Chemical Formula	C43H66N12O12S2
Isoelectric Point	5.51
Hydrophobicity	-2.7
Melting Point (℃)	N.A.
Half Life	1-6 min
Description	9-residue cyclic peptide, synthetically prepared to avert possible contamination with vasopressin and small polypeptides
Indication/Disease	To assist in labor, elective labor induction, uterine contraction induction
Pharmacodynamics	Used to induce labor or to enhance uterine contractions during labor. Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+-dependent phosphorylating enzyme myosin light-chain kinase. Oxytocin promotes contractions by increasing the intracellular Ca2+, which in turn activates myosins light chain kinase.. Oxytocin has specific receptors in the muscle llining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term.
Mechanism of Action	Binds the oxytocin receptor which leads to an increase in intracellular calcium levels. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection.
Toxicity	N.A.
Metabolism	hepatic oxytocinases
Absorption	N.A.
Volume of Distribution	N.A.
Clearance	N.A.
Categories	Oxytocics, Anti-tocolytic Agents and Labor Induction Agents
Patents Number	N.A.
Date of Issue	N.A.
Date of Expiry	N.A.
Drug Interaction	N.A.
Target	Globotriaosylceramide
Information of corresponding available drug in the market
Brand Name	Pitocin
Company	JHP Pharmaceuticals
Brand Discription	Pitocin (oxytocin injection, USP) is a sterile, clear, colorless aqueous solution of synthetic oxytocin, for Intravenous infusion or intramuscular injection. Pitocin is a nonapeptide found in pituitary extracts from mammals. It is standardized to contain 10 units of oxytocic hormone/mL and contains 0.5% Chlorobutanol, a chloroform derivative as a preservative, with the pH adjusted with acetic acid. Pitocin may contain up to 16% of total impurities. The hormone is prepared synthetically to avoid possible contamination with vasopressin (ADH) and other small polypeptides with biologic activity.
Prescribed for	Induction or Stimulation of Labor, Control of Postpartum Uterine Bleeding, Treatment of Incomplete, Inevitable, or Elective Abortion
Chemical Name	N.A.
Formulation	N.A.
Physcial Appearnce	Pitocin (oxytocin injection, USP) is a sterile, clear, colorless aqueous solution of synthetic oxytocin, for Intravenous infusion or intramuscular injection. Pitocin is a nonapeptide found in pituitary extracts from mammals. It is standardized to contain 10 units of oxytocic hormone/mL and contains
Route of Administration	Intravenous infusion
Recommended Dosage	initial dose should be 0.5â€“1 mU/min (equal to 3â€“6 mL of the dilute oxytocin solution per hour). At 30â€“60 minute intervals the dose should be gradually increased in increments of 1â€“2 mU/min until the desired contraction pattern has been established.
Contraindication	Do NOT use Pitocin if: you are allergic to any ingredient in Pitocin; your birth canal is too small compared with the fetus's head; you have other complications that require medical intervention for birth; you have bacteria in the blood; you cannot have a child through vaginal delivery because of certain conditions (eg, genital herpes, cervical cancer)
Side Effects	Symptoms of overdose: Restlessness, shakiness, sleepiness, slow to respond, slurred speech, unconsciousness.
Useful Link	http://www.drugs.com/cdi/pitocin.html http://www.rxlist.com/pitocin-drug/indications-dosage.htm
PubMed ID	14647484, 25637830, 25637811, 25637390, 25631363, 25628581, 25627343
3-D Structure	Th1087 (View) or (Download)