Detailed description page of THPdb

Details of Th1018 which contains 6 entries.

Entry 1
(1) Primary information
ID 1129
ThPP ID Th1018
Therapeutic Peptide/Protein Name Secretin
Sequence HSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional Classification IV
Molecular Weight 3056.4
Chemical Formula C130H219N43O42
Isoelectric Point 9.45
Hydrophobicity -0.463
Melting Point (℃) N.A.
Half Life N.A.
Description This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/Disease For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Pharmacodynamics Secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of Action Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
Toxicity N.A.
Metabolism N.A.
Absorption N.A.
Volume of Distribution N.A.
Clearance N.A.
Categories Diagnostic Agents
Patents Number N.A.
Date of Issue N.A.
Date of Expiry N.A.
Drug Interaction Clidinium. Anticholinergic agents such as secretin may diminish the stimulatory effect of secretin. Avoid using drugs with substantial anticholinergic effects in patients receiving secretin whenever possible. If such agents must be used in combina
Target Secretin receptor
Information of corresponding available drug in the market
Brand Name SecreFlo
Company Repligen Corp
Brand Discription SecreFlo is a pure sterile, nonpyrogenic, lyophilized white cake powder acetate salt of secretin, a peptide hormone. Secretin has an amino acid sequence identical to the naturally occurring porcine secretin consisting of 27 amino acids.
Prescribed for Testing for stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction.
Chemical Name H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser- Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2
Formulation N.A.
Physcial Appearance Lyophilized white powder
Route of Administration Intravenous infusion
Recommended Dosage N.A.
Contraindication Allergy
Side Effects Abdominal discomfort, Nausea, Mild bradycardia (reduced heart rate), Decreased blood pressure and Diaphoresis (profuse perspiration)
Useful Link http://www.medilexicon.com/drugs/secreflo.php
PubMed ID 15780490, 20641871, 25619391
3-D Structure Th1018 (View) or (Download)

Entry 2
(2) Primary information
ID 1130
ThPP ID Th1018
Therapeutic Peptide/Protein Name Secretin
Sequence HSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional Classification IV
Molecular Weight 3056.4
Chemical Formula C130H219N43O42
Isoelectric Point 9.45
Hydrophobicity -0.463
Melting Point (℃) N.A.
Half Life N.A.
Description This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/Disease For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Pharmacodynamics Secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of Action Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
Toxicity N.A.
Metabolism N.A.
Absorption N.A.
Volume of Distribution N.A.
Clearance N.A.
Categories Diagnostic Agents
Patents Number N.A.
Date of Issue N.A.
Date of Expiry N.A.
Drug Interaction Tiotropium.The stimulatory effect of Secretin may be reduced by anticholinergics such as Tiotropium. Concomitant use of Secretin and drugs with substantial anticholinergic effects should be avoided.
Target N.A.
Information of corresponding available drug in the market
Brand Name N.A.
Company N.A.
Brand Discription N.A.
Prescribed for Testing for stimulation of gastrin secretion to aid in the diagnosis of gastrinoma.
Chemical Name N.A.
Formulation N.A.
Physcial Appearance N.A.
Route of Administration N.A.
Recommended Dosage N.A.
Contraindication N.A.
Side Effects N.A.
Useful Link http://www.rxlist.com/secreflo-drug.htm
PubMed ID 15780490, 20641871, 25619391
3-D Structure Th1018 (View) or (Download)

Entry 3
(3) Primary information
ID 1131
ThPP ID Th1018
Therapeutic Peptide/Protein Name Secretin
Sequence HSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional Classification IV
Molecular Weight 3056.4
Chemical Formula C130H219N43O42
Isoelectric Point 9.45
Hydrophobicity -0.463
Melting Point (℃) N.A.
Half Life N.A.
Description This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/Disease For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Pharmacodynamics Secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of Action Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
Toxicity N.A.
Metabolism N.A.
Absorption N.A.
Volume of Distribution N.A.
Clearance N.A.
Categories Diagnostic Agents
Patents Number N.A.
Date of Issue N.A.
Date of Expiry N.A.
Drug Interaction Tolterodine.The stimulatory effect of Secretin may be reduced by anticholinergics such as Tolterodine. Concomitant use of Secretin and drugs with substantial anticholinergic effects should be avoided. If combination therapy must be used, Secretin
Target N.A.
Information of corresponding available drug in the market
Brand Name N.A.
Company N.A.
Brand Discription N.A.
Prescribed for Testing for stimulation of pancreatic secretions to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography(ERCP).
Chemical Name N.A.
Formulation N.A.
Physcial Appearance N.A.
Route of Administration N.A.
Recommended Dosage N.A.
Contraindication N.A.
Side Effects N.A.
Useful Link N.A.
PubMed ID 15780490, 20641871, 25619391
3-D Structure Th1018 (View) or (Download)

Entry 4
(4) Primary information
ID 1132
ThPP ID Th1018
Therapeutic Peptide/Protein Name Secretin
Sequence HSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional Classification IV
Molecular Weight 3056.4
Chemical Formula C130H219N43O42
Isoelectric Point 9.45
Hydrophobicity -0.463
Melting Point (℃) N.A.
Half Life N.A.
Description This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/Disease For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Pharmacodynamics Secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of Action Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
Toxicity N.A.
Metabolism N.A.
Absorption N.A.
Volume of Distribution N.A.
Clearance N.A.
Categories Diagnostic Agents
Patents Number N.A.
Date of Issue N.A.
Date of Expiry N.A.
Drug Interaction Trihexyphenidyl.The stimulatory effect of Secretin may be reduced by anticholinergics such as Trihexyphenidyl. Concomitant use of Secretin and drugs with substantial anticholinergic effects should be avoided. If combination therapy must be used, S
Target N.A.
Information of corresponding available drug in the market
Brand Name Secremax
Company Repligen Corp
Brand Discription N.A.
Prescribed for Used to treat GI spasm, irritable bowel syndrome, hyperperistalsis, peptic ulcer, functional diarrhoea, morning sickness, motion sickness and Dismenorrhoea.
Chemical Name N.A.
Formulation N.A.
Physcial Appearance Solution
Route of Administration Intravenous
Recommended Dosage N.A.
Contraindication N.A.
Side Effects N.A.
Useful Link http://www.igenericdrugs.com/?s=secremax
PubMed ID 15780490, 20641871, 25619391
3-D Structure Th1018 (View) or (Download)

Entry 5
(5) Primary information
ID 1133
ThPP ID Th1018
Therapeutic Peptide/Protein Name Secretin
Sequence HSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional Classification IV
Molecular Weight 3056.4
Chemical Formula C130H219N43O42
Isoelectric Point 9.45
Hydrophobicity -0.463
Melting Point (℃) N.A.
Half Life N.A.
Description This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/Disease For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Pharmacodynamics Secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of Action Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
Toxicity N.A.
Metabolism N.A.
Absorption N.A.
Volume of Distribution N.A.
Clearance N.A.
Categories Diagnostic Agents
Patents Number N.A.
Date of Issue N.A.
Date of Expiry N.A.
Drug Interaction Trimethobenzamide.The stimulatory effect of Secretin may be reduced by anticholinergics such as Trimethobenzamide. Concomitant use of Secretin and drugs with substantial anticholinergic effects should be avoided. If combination therapy must be use
Target N.A.
Information of corresponding available drug in the market
Brand Name N.A.
Company N.A.
Brand Discription N.A.
Prescribed for N.A.
Chemical Name N.A.
Formulation N.A.
Physcial Appearance N.A.
Route of Administration N.A.
Recommended Dosage N.A.
Contraindication N.A.
Side Effects N.A.
Useful Link http://newdruginformation.com/Secremax.htm
PubMed ID 15780490, 20641871, 25619391
3-D Structure Th1018 (View) or (Download)

Entry 6
(6) Primary information
ID 1134
ThPP ID Th1018
Therapeutic Peptide/Protein Name Secretin
Sequence HSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional Classification IV
Molecular Weight 3056.4
Chemical Formula C130H219N43O42
Isoelectric Point 9.45
Hydrophobicity -0.463
Melting Point (℃) N.A.
Half Life N.A.
Description This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/Disease For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Pharmacodynamics Secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of Action Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
Toxicity N.A.
Metabolism N.A.
Absorption N.A.
Volume of Distribution N.A.
Clearance N.A.
Categories Diagnostic Agents
Patents Number N.A.
Date of Issue N.A.
Date of Expiry N.A.
Drug Interaction Trospium.The stimulatory effect of Secretin may be reduced by anticholinergics such as Trospium. Concomitant use of Secretin and drugs with substantial anticholinergic effects should be avoided. If combination therapy must be used, Secretin effica
Target N.A.
Information of corresponding available drug in the market
Brand Name N.A.
Company N.A.
Brand Discription N.A.
Prescribed for N.A.
Chemical Name N.A.
Formulation N.A.
Physcial Appearance N.A.
Route of Administration N.A.
Recommended Dosage N.A.
Contraindication N.A.
Side Effects N.A.
Useful Link N.A.
PubMed ID 15780490, 20641871, 25619391
3-D Structure Th1018 (View) or (Download)

OSDDlinux

Raghava's Group

IMTECH

CSIR

CRDD
CPPSITE 2.0

(1) Primary information
Entry 1
ID	1129
ThPP ID	Th1018
Therapeutic Peptide/Protein Name	Secretin
Sequence	HSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional Classification	IV
Molecular Weight	3056.4
Chemical Formula	C130H219N43O42
Isoelectric Point	9.45
Hydrophobicity	-0.463
Melting Point (℃)	N.A.
Half Life	N.A.
Description	This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/Disease	For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Pharmacodynamics	Secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of Action	Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
Toxicity	N.A.
Metabolism	N.A.
Absorption	N.A.
Volume of Distribution	N.A.
Clearance	N.A.
Categories	Diagnostic Agents
Patents Number	N.A.
Date of Issue	N.A.
Date of Expiry	N.A.
Drug Interaction	Clidinium. Anticholinergic agents such as secretin may diminish the stimulatory effect of secretin. Avoid using drugs with substantial anticholinergic effects in patients receiving secretin whenever possible. If such agents must be used in combina
Target	Secretin receptor
Information of corresponding available drug in the market
Brand Name	SecreFlo
Company	Repligen Corp
Brand Discription	SecreFlo is a pure sterile, nonpyrogenic, lyophilized white cake powder acetate salt of secretin, a peptide hormone. Secretin has an amino acid sequence identical to the naturally occurring porcine secretin consisting of 27 amino acids.
Prescribed for	Testing for stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction.
Chemical Name	H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser- Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2
Formulation	N.A.
Physcial Appearance	Lyophilized white powder
Route of Administration	Intravenous infusion
Recommended Dosage	N.A.
Contraindication	Allergy
Side Effects	Abdominal discomfort, Nausea, Mild bradycardia (reduced heart rate), Decreased blood pressure and Diaphoresis (profuse perspiration)
Useful Link	http://www.medilexicon.com/drugs/secreflo.php
PubMed ID	15780490, 20641871, 25619391
3-D Structure	Th1018 (View) or (Download)

(2) Primary information
Entry 2
ID	1130
ThPP ID	Th1018
Therapeutic Peptide/Protein Name	Secretin
Sequence	HSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional Classification	IV
Molecular Weight	3056.4
Chemical Formula	C130H219N43O42
Isoelectric Point	9.45
Hydrophobicity	-0.463
Melting Point (℃)	N.A.
Half Life	N.A.
Description	This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/Disease	For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Pharmacodynamics	Secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of Action	Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
Toxicity	N.A.
Metabolism	N.A.
Absorption	N.A.
Volume of Distribution	N.A.
Clearance	N.A.
Categories	Diagnostic Agents
Patents Number	N.A.
Date of Issue	N.A.
Date of Expiry	N.A.
Drug Interaction	Tiotropium.The stimulatory effect of Secretin may be reduced by anticholinergics such as Tiotropium. Concomitant use of Secretin and drugs with substantial anticholinergic effects should be avoided.
Target	N.A.
Information of corresponding available drug in the market
Brand Name	N.A.
Company	N.A.
Brand Discription	N.A.
Prescribed for	Testing for stimulation of gastrin secretion to aid in the diagnosis of gastrinoma.
Chemical Name	N.A.
Formulation	N.A.
Physcial Appearance	N.A.
Route of Administration	N.A.
Recommended Dosage	N.A.
Contraindication	N.A.
Side Effects	N.A.
Useful Link	http://www.rxlist.com/secreflo-drug.htm
PubMed ID	15780490, 20641871, 25619391
3-D Structure	Th1018 (View) or (Download)

(3) Primary information
Entry 3
ID	1131
ThPP ID	Th1018
Therapeutic Peptide/Protein Name	Secretin
Sequence	HSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional Classification	IV
Molecular Weight	3056.4
Chemical Formula	C130H219N43O42
Isoelectric Point	9.45
Hydrophobicity	-0.463
Melting Point (℃)	N.A.
Half Life	N.A.
Description	This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/Disease	For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Pharmacodynamics	Secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of Action	Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
Toxicity	N.A.
Metabolism	N.A.
Absorption	N.A.
Volume of Distribution	N.A.
Clearance	N.A.
Categories	Diagnostic Agents
Patents Number	N.A.
Date of Issue	N.A.
Date of Expiry	N.A.
Drug Interaction	Tolterodine.The stimulatory effect of Secretin may be reduced by anticholinergics such as Tolterodine. Concomitant use of Secretin and drugs with substantial anticholinergic effects should be avoided. If combination therapy must be used, Secretin
Target	N.A.
Information of corresponding available drug in the market
Brand Name	N.A.
Company	N.A.
Brand Discription	N.A.
Prescribed for	Testing for stimulation of pancreatic secretions to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography(ERCP).
Chemical Name	N.A.
Formulation	N.A.
Physcial Appearance	N.A.
Route of Administration	N.A.
Recommended Dosage	N.A.
Contraindication	N.A.
Side Effects	N.A.
Useful Link	N.A.
PubMed ID	15780490, 20641871, 25619391
3-D Structure	Th1018 (View) or (Download)

(4) Primary information
Entry 4
ID	1132
ThPP ID	Th1018
Therapeutic Peptide/Protein Name	Secretin
Sequence	HSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional Classification	IV
Molecular Weight	3056.4
Chemical Formula	C130H219N43O42
Isoelectric Point	9.45
Hydrophobicity	-0.463
Melting Point (℃)	N.A.
Half Life	N.A.
Description	This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/Disease	For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Pharmacodynamics	Secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of Action	Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
Toxicity	N.A.
Metabolism	N.A.
Absorption	N.A.
Volume of Distribution	N.A.
Clearance	N.A.
Categories	Diagnostic Agents
Patents Number	N.A.
Date of Issue	N.A.
Date of Expiry	N.A.
Drug Interaction	Trihexyphenidyl.The stimulatory effect of Secretin may be reduced by anticholinergics such as Trihexyphenidyl. Concomitant use of Secretin and drugs with substantial anticholinergic effects should be avoided. If combination therapy must be used, S
Target	N.A.
Information of corresponding available drug in the market
Brand Name	Secremax
Company	Repligen Corp
Brand Discription	N.A.
Prescribed for	Used to treat GI spasm, irritable bowel syndrome, hyperperistalsis, peptic ulcer, functional diarrhoea, morning sickness, motion sickness and Dismenorrhoea.
Chemical Name	N.A.
Formulation	N.A.
Physcial Appearance	Solution
Route of Administration	Intravenous
Recommended Dosage	N.A.
Contraindication	N.A.
Side Effects	N.A.
Useful Link	http://www.igenericdrugs.com/?s=secremax
PubMed ID	15780490, 20641871, 25619391
3-D Structure	Th1018 (View) or (Download)

(5) Primary information
Entry 5
ID	1133
ThPP ID	Th1018
Therapeutic Peptide/Protein Name	Secretin
Sequence	HSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional Classification	IV
Molecular Weight	3056.4
Chemical Formula	C130H219N43O42
Isoelectric Point	9.45
Hydrophobicity	-0.463
Melting Point (℃)	N.A.
Half Life	N.A.
Description	This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/Disease	For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Pharmacodynamics	Secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of Action	Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
Toxicity	N.A.
Metabolism	N.A.
Absorption	N.A.
Volume of Distribution	N.A.
Clearance	N.A.
Categories	Diagnostic Agents
Patents Number	N.A.
Date of Issue	N.A.
Date of Expiry	N.A.
Drug Interaction	Trimethobenzamide.The stimulatory effect of Secretin may be reduced by anticholinergics such as Trimethobenzamide. Concomitant use of Secretin and drugs with substantial anticholinergic effects should be avoided. If combination therapy must be use
Target	N.A.
Information of corresponding available drug in the market
Brand Name	N.A.
Company	N.A.
Brand Discription	N.A.
Prescribed for	N.A.
Chemical Name	N.A.
Formulation	N.A.
Physcial Appearance	N.A.
Route of Administration	N.A.
Recommended Dosage	N.A.
Contraindication	N.A.
Side Effects	N.A.
Useful Link	http://newdruginformation.com/Secremax.htm
PubMed ID	15780490, 20641871, 25619391
3-D Structure	Th1018 (View) or (Download)

(6) Primary information
Entry 6
ID	1134
ThPP ID	Th1018
Therapeutic Peptide/Protein Name	Secretin
Sequence	HSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional Classification	IV
Molecular Weight	3056.4
Chemical Formula	C130H219N43O42
Isoelectric Point	9.45
Hydrophobicity	-0.463
Melting Point (℃)	N.A.
Half Life	N.A.
Description	This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/Disease	For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Pharmacodynamics	Secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of Action	Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
Toxicity	N.A.
Metabolism	N.A.
Absorption	N.A.
Volume of Distribution	N.A.
Clearance	N.A.
Categories	Diagnostic Agents
Patents Number	N.A.
Date of Issue	N.A.
Date of Expiry	N.A.
Drug Interaction	Trospium.The stimulatory effect of Secretin may be reduced by anticholinergics such as Trospium. Concomitant use of Secretin and drugs with substantial anticholinergic effects should be avoided. If combination therapy must be used, Secretin effica
Target	N.A.
Information of corresponding available drug in the market
Brand Name	N.A.
Company	N.A.
Brand Discription	N.A.
Prescribed for	N.A.
Chemical Name	N.A.
Formulation	N.A.
Physcial Appearance	N.A.
Route of Administration	N.A.
Recommended Dosage	N.A.
Contraindication	N.A.
Side Effects	N.A.
Useful Link	N.A.
PubMed ID	15780490, 20641871, 25619391
3-D Structure	Th1018 (View) or (Download)