==== Reference: Usmani SS, Bedi G, Samuel JS, Singh S, Kalra S, Kumar P, et al. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLoS ONE 12(7) e0181748.====

Detailed description page of THPdb


Details of Th1038 which contains 4 entries.


Entry 1
(1) Primary information
ID1265
ThPP IDTh1038
Therapeutic Peptide/Protein NameOmalizumab
SequenceHeavy chain: EVQLVESGGGLVQPGGSLRLSCAVSGYSITSGYSWNW view full sequnce in fasta
Functional ClassificationIIa
Molecular Weight145058.2
Chemical FormulaC6450H9916N1714O2023S38
Isoelectric Point7.03
Hydrophobicity-0.432
Melting Point (℃)61(FAB fra
Half Life624 hours
DescriptionA recombinant DNA-derived humanized IgG1k monoclonal antibody that selectively binds to human immunoglobulin E. Xolair is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin.
Indication/DiseaseFor treatment of asthma caused by allergies
PharmacodynamicsXolair inhibits the binding of IgE to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Reduction in surface-bound IgE on FceRI-bearing cells limits the degree of release of mediators of the allergic response. Xolair is used to treat severe, persisten asthma.
Mechanism of ActionXolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils.
ToxicityN.A.
MetabolismMost likely removed by opsonization via the reticuloendothelial system.
AbsorptionN.A.
Volume of Distribution78 ± 32 mL/kg
ClearanceLiver elimination of IgG includes degradation in the liver reticuloendothelial system (RES) and endothelial cells. Intact IgG is also excreted in bile.
CategoriesAnti-Allergic Agents
Patents NumberCA2113813
Date of Issue12/04/05
Date of Expiry14/08/12
Drug InteractionN.A.
TargetHigh affinity immunoglobulin epsilon receptor subunit alpha and beta
Information of corresponding available drug in the market
Brand NameXolair
CompanyGenentech Inc
Brand DiscriptionXolair is a recombinant DNA-derived humanized IgG1_ monoclonal antibody that selectively binds to human immunoglobulin E (IgE). The antibody has a molecular weight of approximately 149 kiloDaltons. Xolair is produced by a Chinese hamster ovary cell suspen
Prescribed forXolair is used to treat moderate to severe asthma that is caused by allergies, and chronic idiopathic urticaria (a form of chronic hives) in adults and children who are at least 12 years old. Xolair is usually given after other asthma medications have bee
Chemical NameN.A.
FormulationFormulated in a single use vial that is reconstituted with sterile water for injection (SWFI), USP, and administered as a subcutaneous (SC) injection. Each 202.5 mg vial of omalizumab also contains L-histidine (1.8 mg), L-histidine hydrochloride monohydra
Physcial AppearanceSterile, white, preservative free, lyophilized powder
Route of AdministrationSubcutaneous Injection
Recommended DosageXolair is administered at 150 to 375 mg by subcutaneous injection every 2 or 4 weeks. Determine doses (mg) and dosing frequency by serum total IgE level (IU/mL), measured before the start of treatment, and body weight (kg) as if serum IgE is less than 30-or >700 IU/mL and <66 or >330 lb, respectively) should not be dosed.
ContraindicationSevere hypersensitivity
Side EffectsWheezing, tightness in your chest, trouble breathing; hives or skin rash; feeling anxious or light-headed, fainting; warmth or tingling under your skin; or swelling of your face, lips, tongue, or throat.
Useful Linkhttp://www.xolair.com
PubMed ID27426720, 16810345, 16179960, 28319473, 28314658, 28303277, 28303134, 28302544, 28295198
3-D StructureTh1038 (View) or (Download)


Entry 2
(2) Primary information
ID1266
ThPP IDTh1038
Therapeutic Peptide/Protein NameOmalizumab
SequenceHeavy chain: EVQLVESGGGLVQPGGSLRLSCAVSGYSITSGYSWNW view full sequnce in fasta
Functional ClassificationIIa
Molecular Weight145058.2
Chemical FormulaC6450H9916N1714O2023S38
Isoelectric Point7.03
Hydrophobicity-0.432
Melting Point (℃)61(FAB fra
Half Life624 hours
DescriptionA recombinant DNA-derived humanized IgG1k monoclonal antibody that selectively binds to human immunoglobulin E. Xolair is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin.
Indication/DiseaseFor treatment of asthma caused by allergies
PharmacodynamicsXolair inhibits the binding of IgE to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Reduction in surface-bound IgE on FceRI-bearing cells limits the degree of release of mediators of the allergic response. Xolair is used to treat severe, persisten asthma.
Mechanism of ActionXolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils.
ToxicityN.A.
MetabolismMost likely removed by opsonization via the reticuloendothelial system.
AbsorptionN.A.
Volume of Distribution78 ± 32 mL/kg
ClearanceLiver elimination of IgG includes degradation in the liver reticuloendothelial system (RES) and endothelial cells. Intact IgG is also excreted in bile.
CategoriesAnti-Asthmatic Agents
Patents NumberCA1340233
Date of Issue15/12/98
Date of Expiry15/12/15
Drug InteractionN.A.
TargetN.A.
Information of corresponding available drug in the market
Brand NameN.A.
CompanyN.A.
Brand DiscriptionN.A.
Prescribed forN.A.
Chemical NameN.A.
FormulationN.A.
Physcial AppearanceN.A.
Route of AdministrationN.A.
Recommended DosageN.A.
ContraindicationN.A.
Side EffectsPain; headache, tired feeling; joint or muscle pain; dizziness; ear pain; hair loss; mild itching or skin rash; sore throat or cold symptoms; or redness, bruising, warmth, burning, stinging, itching, pain, or swelling of your skin where the injection was given.
Useful Linkhttp://www.drugs.com/xolair.html
PubMed ID27426720, 16810345, 16179960, 28319473, 28314658, 28303277, 28303134, 28302544, 28295198
3-D StructureTh1038 (View) or (Download)


Entry 3
(3) Primary information
ID1267
ThPP IDTh1038
Therapeutic Peptide/Protein NameOmalizumab
SequenceHeavy chain: EVQLVESGGGLVQPGGSLRLSCAVSGYSITSGYSWNW view full sequnce in fasta
Functional ClassificationIIa
Molecular Weight145058.2
Chemical FormulaC6450H9916N1714O2023S38
Isoelectric Point7.03
Hydrophobicity-0.432
Melting Point (℃)61(FAB fra
Half Life624 hours
DescriptionA recombinant DNA-derived humanized IgG1k monoclonal antibody that selectively binds to human immunoglobulin E. Xolair is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin.
Indication/DiseaseFor treatment of asthma caused by allergies
PharmacodynamicsXolair inhibits the binding of IgE to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Reduction in surface-bound IgE on FceRI-bearing cells limits the degree of release of mediators of the allergic response. Xolair is used to treat severe, persisten asthma.
Mechanism of ActionXolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils.
ToxicityN.A.
MetabolismMost likely removed by opsonization via the reticuloendothelial system.
AbsorptionN.A.
Volume of Distribution78 ± 32 mL/kg
ClearanceLiver elimination of IgG includes degradation in the liver reticuloendothelial system (RES) and endothelial cells. Intact IgG is also excreted in bile.
CategoriesImmunosuppressive Agents
Patents NumberN.A.
Date of IssueN.A.
Date of ExpiryN.A.
Drug InteractionN.A.
TargetN.A.
Information of corresponding available drug in the market
Brand NameN.A.
CompanyN.A.
Brand DiscriptionN.A.
Prescribed forN.A.
Chemical NameN.A.
FormulationN.A.
Physcial AppearanceN.A.
Route of AdministrationN.A.
Recommended DosageN.A.
ContraindicationN.A.
Side EffectsN.A.
Useful Linkhttp://www.drugs.com/drug-interactions/omalizumab,xolair-index.html
PubMed ID27426720, 16810345, 16179960, 28319473, 28314658, 28303277, 28303134, 28302544, 28295198
3-D StructureTh1038 (View) or (Download)


Entry 4
(4) Primary information
ID1268
ThPP IDTh1038
Therapeutic Peptide/Protein NameOmalizumab
SequenceHeavy chain: EVQLVESGGGLVQPGGSLRLSCAVSGYSITSGYSWNW view full sequnce in fasta
Functional ClassificationIIa
Molecular Weight145058.2
Chemical FormulaC6450H9916N1714O2023S38
Isoelectric Point7.03
Hydrophobicity-0.432
Melting Point (℃)61(FAB fra
Half Life624 hours
DescriptionA recombinant DNA-derived humanized IgG1k monoclonal antibody that selectively binds to human immunoglobulin E. Xolair is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin.
Indication/DiseaseFor treatment of asthma caused by allergies
PharmacodynamicsXolair inhibits the binding of IgE to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Reduction in surface-bound IgE on FceRI-bearing cells limits the degree of release of mediators of the allergic response. Xolair is used to treat severe, persisten asthma.
Mechanism of ActionXolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils.
ToxicityN.A.
MetabolismMost likely removed by opsonization via the reticuloendothelial system.
AbsorptionN.A.
Volume of Distribution78 ± 32 mL/kg
ClearanceLiver elimination of IgG includes degradation in the liver reticuloendothelial system (RES) and endothelial cells. Intact IgG is also excreted in bile.
CategoriesN.A.
Patents NumberN.A.
Date of IssueN.A.
Date of ExpiryN.A.
Drug InteractionN.A.
TargetN.A.
Information of corresponding available drug in the market
Brand NameN.A.
CompanyN.A.
Brand DiscriptionN.A.
Prescribed forN.A.
Chemical NameN.A.
FormulationN.A.
Physcial AppearanceN.A.
Route of AdministrationN.A.
Recommended DosageN.A.
ContraindicationN.A.
Side EffectsN.A.
Useful Linkhttp://www.rxlist.com/xolair-drug.htm
PubMed ID27426720, 16810345, 16179960, 28319473, 28314658, 28303277, 28303134, 28302544, 28295198
3-D StructureTh1038 (View) or (Download)