Detailed description page of THPdb

Details of Th1056 which contains 1 entries.

Entry 1
(1) Primary information
ID 1375
ThPP ID Th1056
Therapeutic Peptide/Protein Name Vasopressin
Sequence CYFQNCPRG view full sequnce in fasta
Functional Classification Ib
Molecular Weight 1050.215
Chemical Formula C43H67N15O12S2
Isoelectric Point N.A.
Hydrophobicity -4.9
Melting Point (℃) N.A.
Half Life 10-20 minutes
Description Antidiuretic hormone, also known as vasopressin, is a nine amino acid peptide secreted from the posterior pituitary. Antidiuretic hormone binds to receptors in the distal or collecting tubules of the kidney and promotes reabsorbtion of water back into the circulation.
Indication/Disease For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding
Pharmacodynamics Vasopressin is an antidiuretic hormone indicated for the prevention and treatment of postoperative abdominal distention, in abdominal roentgenography to dispel interfering gas shadows, and in diabetes insipidus. Vasopressin can cause contraction of smooth muscle of the gastrointestinal tract and of all parts of the vascular bed, especially the capillaries, small arterioles and venules. It has less effect on the smooth musculature of the large veins. Vasopressin may also be used to control bleeding in some forms of von Willebrand disease and to treat extreme cases of bed wetting in children. It may also play a role in memory formation although the mechanism is unknown.
Mechanism of Action Vasopressin acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of vasopressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
Toxicity N.A.
Metabolism The majority of a dose of vasopressin is metabolized and rapidly destroyed in the liver and kidneys.
Absorption N.A.
Volume of Distribution N.A.
Clearance N.A.
Categories Antidiuretic Agents
Patents Number N.A.
Date of Issue N.A.
Date of Expiry N.A.
Drug Interaction N.A.
Target Vasopressin V2 receptor,Vasopressin V1a receptor,Vasopressin V1b receptor
Information of corresponding available drug in the market
Brand Name Pitressin
Company JHP Pharmaceuticals
Brand Discription Vasopressin Injection, USP is a sterile, aqueous solution of synthetic vasopressin (8-L-arginine vasopressin) of the posterior pituitary gland for intramuscular or subcutaneous use. It is substantially free from the oxytocic principle and is standardized to contain 20 pressor units/mL.
Prescribed for Vasopressin is indicated for prevention and treatment of postoperative abdominal distention, in abdominal roentgenography to dispel interfering gas shadows, and in diabetes insipidus.
Chemical Name N.A.
Formulation Vasopressin 20 units, Sodium Chloride 9 mg, Chlorobutanol 0.5% (as a preservative), Water for Injection q.s. pH (range 2.5 - 4.5) adjusted with Acetic Acid.
Physcial Appearance Vasopressin Injection, USP is a Sterile, aqueous solution of synthetic vasopressin (8-L-arginine vasopressin) of the posterior pituitary gland
Route of Administration intramuSubcutaneousular or Subcutaneous use
Recommended Dosage For Abdominal Distention, Abdominal Roentgenography, Diabetes Insipidus: Ten units of vassopressin (0.5mL) will usually elicit full physiologic response in adult patients.
Contraindication Anaphylaxis or hypersensitivity to the drug or its components.
Side Effects anaphylaxia (cardiac arrest), circumoral pallor, arrhythmias, decreased cardiac output, angina, myocardial ischemia, peripheral vasoconstruction and gangrene, nausea, vomiting, tremor, vertigo, bronchial constriction
Useful Link http://www.rxlist.com/pitressin-drug.ht http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=812240e4-fc28-46c2-92f3-1ba4e029645a
PubMed ID 17122081, 17083331, 15555506, 14647484, 7545469
3-D Structure Th1056 (View) or (Download)

OSDDlinux

Raghava's Group

IMTECH

CSIR

CRDD
CPPSITE 2.0

(1) Primary information
Entry 1
ID	1375
ThPP ID	Th1056
Therapeutic Peptide/Protein Name	Vasopressin
Sequence	CYFQNCPRG view full sequnce in fasta
Functional Classification	Ib
Molecular Weight	1050.215
Chemical Formula	C43H67N15O12S2
Isoelectric Point	N.A.
Hydrophobicity	-4.9
Melting Point (℃)	N.A.
Half Life	10-20 minutes
Description	Antidiuretic hormone, also known as vasopressin, is a nine amino acid peptide secreted from the posterior pituitary. Antidiuretic hormone binds to receptors in the distal or collecting tubules of the kidney and promotes reabsorbtion of water back into the circulation.
Indication/Disease	For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding
Pharmacodynamics	Vasopressin is an antidiuretic hormone indicated for the prevention and treatment of postoperative abdominal distention, in abdominal roentgenography to dispel interfering gas shadows, and in diabetes insipidus. Vasopressin can cause contraction of smooth muscle of the gastrointestinal tract and of all parts of the vascular bed, especially the capillaries, small arterioles and venules. It has less effect on the smooth musculature of the large veins. Vasopressin may also be used to control bleeding in some forms of von Willebrand disease and to treat extreme cases of bed wetting in children. It may also play a role in memory formation although the mechanism is unknown.
Mechanism of Action	Vasopressin acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of vasopressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
Toxicity	N.A.
Metabolism	The majority of a dose of vasopressin is metabolized and rapidly destroyed in the liver and kidneys.
Absorption	N.A.
Volume of Distribution	N.A.
Clearance	N.A.
Categories	Antidiuretic Agents
Patents Number	N.A.
Date of Issue	N.A.
Date of Expiry	N.A.
Drug Interaction	N.A.
Target	Vasopressin V2 receptor,Vasopressin V1a receptor,Vasopressin V1b receptor
Information of corresponding available drug in the market
Brand Name	Pitressin
Company	JHP Pharmaceuticals
Brand Discription	Vasopressin Injection, USP is a sterile, aqueous solution of synthetic vasopressin (8-L-arginine vasopressin) of the posterior pituitary gland for intramuscular or subcutaneous use. It is substantially free from the oxytocic principle and is standardized to contain 20 pressor units/mL.
Prescribed for	Vasopressin is indicated for prevention and treatment of postoperative abdominal distention, in abdominal roentgenography to dispel interfering gas shadows, and in diabetes insipidus.
Chemical Name	N.A.
Formulation	Vasopressin 20 units, Sodium Chloride 9 mg, Chlorobutanol 0.5% (as a preservative), Water for Injection q.s. pH (range 2.5 - 4.5) adjusted with Acetic Acid.
Physcial Appearance	Vasopressin Injection, USP is a Sterile, aqueous solution of synthetic vasopressin (8-L-arginine vasopressin) of the posterior pituitary gland
Route of Administration	intramuSubcutaneousular or Subcutaneous use
Recommended Dosage	For Abdominal Distention, Abdominal Roentgenography, Diabetes Insipidus: Ten units of vassopressin (0.5mL) will usually elicit full physiologic response in adult patients.
Contraindication	Anaphylaxis or hypersensitivity to the drug or its components.
Side Effects	anaphylaxia (cardiac arrest), circumoral pallor, arrhythmias, decreased cardiac output, angina, myocardial ischemia, peripheral vasoconstruction and gangrene, nausea, vomiting, tremor, vertigo, bronchial constriction
Useful Link	http://www.rxlist.com/pitressin-drug.ht http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=812240e4-fc28-46c2-92f3-1ba4e029645a
PubMed ID	17122081, 17083331, 15555506, 14647484, 7545469
3-D Structure	Th1056 (View) or (Download)