==== Reference: Usmani SS, Bedi G, Samuel JS, Singh S, Kalra S, Kumar P, et al. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLoS ONE 12(7) e0181748.====

Detailed description page of THPdb


Details of Th1187 which contains 8 entries.


Entry 1
(1) Primary information
ID1772
ThPP IDTh1187
Therapeutic Peptide/Protein NameHuman Rho(D) immune globulin
SequenceNA view full sequnce in fasta
Functional ClassificationIIIb
Molecular WeightNA
Chemical FormulaNA
Isoelectric PointNA
HydrophobicityNA
Melting Point (℃)NA
Half Life24 - 30.9 days
DescriptionHuman Rho(D) immune globulin is a medicine given by intramuscular injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Human Rho(D) immune globulin is produced by an ion-exchange chromatography isolation procedure, using pooled plasma obtained by plasmapheresis of immunized Rh0(D)-negative US donors.
Indication/DiseaseNA
PharmacodynamicsNA
Mechanism of ActionIt acts by suppressing the immune response of Rh-negative individuals to Rh-positive red blood cells. The mechanism of action is unknown. RhoGAM, MICRhoGAM and other Rho(D) Immune Globulin (Human) products are not effective in altering the course or consequences of Rh immunization once it has occurred.
ToxicityNA
MetabolismNA
AbsorptionNA
Volume of Distribution7.3 - 8.6 L
ClearanceNA
CategoriesNA
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetNA
Information of corresponding available drug in the market
Brand NameHyp Rho D Inj 16.5%
CompanyCutter Med & Biol, Division Of Miles Canada Ltd.
Brand DiscriptionNA
Prescribed forNA
Chemical NameNA
Formulation16.50%
Physcial Appearanceliquid
Route of AdministrationIntramuscular
Recommended DosageNA
ContraindicationNA
Side EffectsNA
Useful Linkhttp://www.rxlist.com/rhogam-ultra-filtered-plus-drug/clinical-pharmacology.htm
PubMed ID2824867
3-D StructureN.A.


Entry 2
(2) Primary information
ID1773
ThPP IDTh1187
Therapeutic Peptide/Protein NameHuman Rho(D) immune globulin
SequenceNA view full sequnce in fasta
Functional ClassificationIIIb
Molecular WeightNA
Chemical FormulaNA
Isoelectric PointNA
HydrophobicityNA
Melting Point (℃)NA
Half Life24 - 30.9 days
DescriptionHuman Rho(D) immune globulin is a medicine given by intramuscular injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Human Rho(D) immune globulin is produced by an ion-exchange chromatography isolation procedure, using pooled plasma obtained by plasmapheresis of immunized Rh0(D)-negative US donors.
Indication/DiseaseNA
PharmacodynamicsNA
Mechanism of ActionIt acts by suppressing the immune response of Rh-negative individuals to Rh-positive red blood cells. The mechanism of action is unknown. RhoGAM, MICRhoGAM and other Rho(D) Immune Globulin (Human) products are not effective in altering the course or consequences of Rh immunization once it has occurred.
ToxicityNA
MetabolismNA
AbsorptionNA
Volume of Distribution7.3 - 8.6 L
ClearanceNA
CategoriesNA
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetNA
Information of corresponding available drug in the market
Brand NameHyperrho S/d Full Dose
CompanyGRIFOLS USA, LLC
Brand DiscriptionNA
Prescribed forNA
Chemical NameNA
Formulation1500 [iU]/1
Physcial AppearanceSoution
Route of AdministrationIntramuscular
Recommended DosageNA
ContraindicationNA
Side EffectsNA
Useful Linkhttp://www.rxlist.com/rhogam-ultra-filtered-plus-drug/clinical-pharmacology.htm
PubMed ID2824867
3-D StructureN.A.


Entry 3
(3) Primary information
ID1774
ThPP IDTh1187
Therapeutic Peptide/Protein NameHuman Rho(D) immune globulin
SequenceNA view full sequnce in fasta
Functional ClassificationIIIb
Molecular WeightNA
Chemical FormulaNA
Isoelectric PointNA
HydrophobicityNA
Melting Point (℃)NA
Half Life24 - 30.9 days
DescriptionHuman Rho(D) immune globulin is a medicine given by intramuscular injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Human Rho(D) immune globulin is produced by an ion-exchange chromatography isolation procedure, using pooled plasma obtained by plasmapheresis of immunized Rh0(D)-negative US donors.
Indication/DiseaseNA
PharmacodynamicsNA
Mechanism of ActionIt acts by suppressing the immune response of Rh-negative individuals to Rh-positive red blood cells. The mechanism of action is unknown. RhoGAM, MICRhoGAM and other Rho(D) Immune Globulin (Human) products are not effective in altering the course or consequences of Rh immunization once it has occurred.
ToxicityNA
MetabolismNA
AbsorptionNA
Volume of Distribution7.3 - 8.6 L
ClearanceNA
CategoriesNA
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetNA
Information of corresponding available drug in the market
Brand NameHyperrho S/d Mini-dose
CompanyGRIFOLS USA, LLC
Brand DiscriptionNA
Prescribed forNA
Chemical NameNA
Formulation250 [iU]/1
Physcial AppearanceSolution
Route of AdministrationIntramuscular
Recommended DosageNA
ContraindicationNA
Side EffectsNA
Useful Linkhttp://www.rxlist.com/rhogam-ultra-filtered-plus-drug/clinical-pharmacology.htm
PubMed ID2824867
3-D StructureN.A.


Entry 4
(4) Primary information
ID1775
ThPP IDTh1187
Therapeutic Peptide/Protein NameHuman Rho(D) immune globulin
SequenceNA view full sequnce in fasta
Functional ClassificationIIIb
Molecular WeightNA
Chemical FormulaNA
Isoelectric PointNA
HydrophobicityNA
Melting Point (℃)NA
Half Life24 - 30.9 days
DescriptionHuman Rho(D) immune globulin is a medicine given by intramuscular injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Human Rho(D) immune globulin is produced by an ion-exchange chromatography isolation procedure, using pooled plasma obtained by plasmapheresis of immunized Rh0(D)-negative US donors.
Indication/DiseaseNA
PharmacodynamicsNA
Mechanism of ActionIt acts by suppressing the immune response of Rh-negative individuals to Rh-positive red blood cells. The mechanism of action is unknown. RhoGAM, MICRhoGAM and other Rho(D) Immune Globulin (Human) products are not effective in altering the course or consequences of Rh immunization once it has occurred.
ToxicityNA
MetabolismNA
AbsorptionNA
Volume of Distribution7.3 - 8.6 L
ClearanceNA
CategoriesNA
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetNA
Information of corresponding available drug in the market
Brand NameMicrhogam Ultra-filtered Plus
CompanyKedrion Melville, Inc.
Brand DiscriptionNA
Prescribed forNA
Chemical NameNA
Formulation50 ug/1
Physcial Appearanceinjection, solution
Route of AdministrationIntramuscular
Recommended DosageNA
ContraindicationNA
Side EffectsNA
Useful Linkhttp://www.rxlist.com/rhogam-ultra-filtered-plus-drug/clinical-pharmacology.htm
PubMed ID2824867
3-D StructureN.A.


Entry 5
(5) Primary information
ID1776
ThPP IDTh1187
Therapeutic Peptide/Protein NameHuman Rho(D) immune globulin
SequenceNA view full sequnce in fasta
Functional ClassificationIIIb
Molecular WeightNA
Chemical FormulaNA
Isoelectric PointNA
HydrophobicityNA
Melting Point (℃)NA
Half Life24 - 30.9 days
DescriptionHuman Rho(D) immune globulin is a medicine given by intramuscular injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Human Rho(D) immune globulin is produced by an ion-exchange chromatography isolation procedure, using pooled plasma obtained by plasmapheresis of immunized Rh0(D)-negative US donors.
Indication/DiseaseNA
PharmacodynamicsNA
Mechanism of ActionIt acts by suppressing the immune response of Rh-negative individuals to Rh-positive red blood cells. The mechanism of action is unknown. RhoGAM, MICRhoGAM and other Rho(D) Immune Globulin (Human) products are not effective in altering the course or consequences of Rh immunization once it has occurred.
ToxicityNA
MetabolismNA
AbsorptionNA
Volume of Distribution7.3 - 8.6 L
ClearanceNA
CategoriesNA
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetNA
Information of corresponding available drug in the market
Brand NameRhogam Ultra-filtered Plus
CompanyKedrion Melville, Inc.
Brand DiscriptionNA
Prescribed forNA
Chemical NameNA
Formulation300 ug/1
Physcial Appearanceinjection, solution
Route of AdministrationIntramuscular
Recommended DosageNA
ContraindicationNA
Side EffectsNA
Useful Linkhttp://www.rxlist.com/rhogam-ultra-filtered-plus-drug/clinical-pharmacology.htm
PubMed ID2824867
3-D StructureN.A.


Entry 6
(6) Primary information
ID1777
ThPP IDTh1187
Therapeutic Peptide/Protein NameHuman Rho(D) immune globulin
SequenceNA view full sequnce in fasta
Functional ClassificationIIIb
Molecular WeightNA
Chemical FormulaNA
Isoelectric PointNA
HydrophobicityNA
Melting Point (℃)NA
Half Life24 - 30.9 days
DescriptionHuman Rho(D) immune globulin is a medicine given by intramuscular injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Human Rho(D) immune globulin is produced by an ion-exchange chromatography isolation procedure, using pooled plasma obtained by plasmapheresis of immunized Rh0(D)-negative US donors.
Indication/DiseaseNA
PharmacodynamicsNA
Mechanism of ActionIt acts by suppressing the immune response of Rh-negative individuals to Rh-positive red blood cells. The mechanism of action is unknown. RhoGAM, MICRhoGAM and other Rho(D) Immune Globulin (Human) products are not effective in altering the course or consequences of Rh immunization once it has occurred.
ToxicityNA
MetabolismNA
AbsorptionNA
Volume of Distribution7.3 - 8.6 L
ClearanceNA
CategoriesNA
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetNA
Information of corresponding available drug in the market
Brand NameRhophylac
CompanyCsl Behring Ag
Brand DiscriptionNA
Prescribed forNA
Chemical NameNA
Formulation1500 [iU]/2mL
Physcial Appearancesolution
Route of Administrationintramuscular; intravenous
Recommended DosageNA
ContraindicationNA
Side EffectsNA
Useful Linkhttp://www.rxlist.com/rhogam-ultra-filtered-plus-drug/clinical-pharmacology.htm
PubMed ID2824867
3-D StructureN.A.


Entry 7
(7) Primary information
ID1778
ThPP IDTh1187
Therapeutic Peptide/Protein NameHuman Rho(D) immune globulin
SequenceNA view full sequnce in fasta
Functional ClassificationIIIb
Molecular WeightNA
Chemical FormulaNA
Isoelectric PointNA
HydrophobicityNA
Melting Point (℃)NA
Half Life24 - 30.9 days
DescriptionHuman Rho(D) immune globulin is a medicine given by intramuscular injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Human Rho(D) immune globulin is produced by an ion-exchange chromatography isolation procedure, using pooled plasma obtained by plasmapheresis of immunized Rh0(D)-negative US donors.
Indication/DiseaseNA
PharmacodynamicsNA
Mechanism of ActionIt acts by suppressing the immune response of Rh-negative individuals to Rh-positive red blood cells. The mechanism of action is unknown. RhoGAM, MICRhoGAM and other Rho(D) Immune Globulin (Human) products are not effective in altering the course or consequences of Rh immunization once it has occurred.
ToxicityNA
MetabolismNA
AbsorptionNA
Volume of Distribution7.3 - 8.6 L
ClearanceNA
CategoriesNA
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetNA
Information of corresponding available drug in the market
Brand NameWinrho Sdf
CompanyAptevo Biotherapeutics Llc
Brand DiscriptionNA
Prescribed forNA
Chemical NameNA
Formulation5000 unit; 1500 unit; 600 unit
Physcial Appearancekit
Route of Administrationintramuscular; intravenous
Recommended DosageNA
ContraindicationNA
Side EffectsNA
Useful Linkhttp://www.rxlist.com/rhogam-ultra-filtered-plus-drug/clinical-pharmacology.htm
PubMed ID2824867
3-D StructureN.A.


Entry 8
(8) Primary information
ID1779
ThPP IDTh1187
Therapeutic Peptide/Protein NameHuman Rho(D) immune globulin
SequenceNA view full sequnce in fasta
Functional ClassificationIIIb
Molecular WeightNA
Chemical FormulaNA
Isoelectric PointNA
HydrophobicityNA
Melting Point (℃)NA
Half Life24 - 30.9 days
DescriptionHuman Rho(D) immune globulin is a medicine given by intramuscular injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Human Rho(D) immune globulin is produced by an ion-exchange chromatography isolation procedure, using pooled plasma obtained by plasmapheresis of immunized Rh0(D)-negative US donors.
Indication/DiseaseNA
PharmacodynamicsNA
Mechanism of ActionIt acts by suppressing the immune response of Rh-negative individuals to Rh-positive red blood cells. The mechanism of action is unknown. RhoGAM, MICRhoGAM and other Rho(D) Immune Globulin (Human) products are not effective in altering the course or consequences of Rh immunization once it has occurred.
ToxicityNA
MetabolismNA
AbsorptionNA
Volume of DistributionNA
ClearanceNA
CategoriesNA
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetNA
Information of corresponding available drug in the market
Brand NameWinrho Sdf (liquid Formulation)
CompanyAptevo Biotherapeutics Llc
Brand DiscriptionNA
Prescribed forNA
Chemical NameNA
Formulation15000 unit
Physcial Appearanceliquid
Route of Administrationintramuscular; intravenous
Recommended DosageNA
ContraindicationNA
Side EffectsNA
Useful Linkhttp://www.rxlist.com/rhogam-ultra-filtered-plus-drug/clinical-pharmacology.htm
PubMed ID2824867
3-D StructureN.A.