==== Reference: Usmani SS, Bedi G, Samuel JS, Singh S, Kalra S, Kumar P, et al. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLoS ONE 12(7) e0181748.====

Detailed description page of THPdb


Details of Th1220 which contains 1 entries.


Entry 1
(1) Primary information
ID1830
ThPP IDTh1220
Therapeutic Peptide/Protein NameBrodalumab
SequenceNA view full sequnce in fasta
Functional ClassificationIIa
Molecular Weight1,44,000
Chemical Formula C6372H9840N1712O1988S52
Isoelectric PointNA
HydrophobicityNA
Melting Point (℃)NA
Half LifeNA
DescriptionBrodalumab has been used in trials studying the treatment of Asthma, Psoriasis, Crohn's Disease, Psoriatic Arthritis, and Rheumatoid Arthritis. Brodalumab was FDA approved in February, 2017 as Siliq for the treatment of moderate-to-severe plaque psoriasis.
Indication/DiseaseBrodalumab has been approved for the treatment of psoriasis vulgaris, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma.
Pharmacodynamics Increase in the level of IL-17 due to blocking of its receptors.
Mechanism of ActionBrodalumab binds with high affinity to interleukin (IL)-17 receptor A, thereby inhibiting several pro-inflammatory cytokines from the IL-17 family.
ToxicityNA
MetabolismNA
AbsorptionNA
Volume of Distribution4.62 L
Clearance0.223 L/day.
CategoriesAntineoplastic and Immunomodulating Agents
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionThe risk or severity of adverse effects can be increased with combination of drugs like BCG, Denosumab, Fingolimod, G17DT, GI-5005, INGN 201, INGN 225, Leflunomide, Natalizumab, Pimecrolimus.
Target Interleukin 17 receptor A
Information of corresponding available drug in the market
Brand NameSiliq
CompanyNA
Brand DiscriptionBrodalumab (Siiliq) is a human monoclonal IgG2κ antibody directed against human interleukin-17 receptor A (IL-17RA). It is expressed in a Chinese Hamster Ovary (CHO) cell line. Brodalumab is comprised of 1312 amino acids and has an estimated molecular mass of 144,000 Daltons.
Prescribed forSILIQâ„¢ is indicated for the treatment of moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy and have failed to respond or have lost response to other systemic therapies.
Chemical NameNA
FormulationEach SILIQ single-dose prefilled syringe delivers 1.5 mL of solution containing 210 mg of brodalumab formulated in glutamate (6.5 mg), polysorbate 20 (0.15 mg), proline (36 mg), and Water for Injection, USP at pH 4.8.
Physcial Appearancesterile, preservative-free, clear to slightly opalescent, colorless to slightly yellow solution
Route of AdministrationSubcutaneous
Recommended DosageThe recommended SILIQ dose is 210 mg administered by subcutaneous injection at Weeks 0, 1, and 2 followed by 210 mg every 2 weeks.
ContraindicationSILIQ is contraindicated in patients with Crohn’s disease because SILIQ may cause worsening of disease
Side EffectsSuicidal Ideation and Behavior, Infection and Crohn’s Disease
Useful Linkhttp://www.rxlist.com/siliq-drug.htm
PubMed ID27577550, 24846347
3-D StructureN.A.