ASPsiRNA is the first comprehensive resource encompassing therapeutically important ASP-siRNAs and prediction of their inhibitory efficacy. It contains three components ASPsiDb, ASPsiPred and Off-Target analysis.
ASPsiDb harbors Allele-specific siRNAs targeting 78 unique genes from 51 different human genetic diseases. It is manually curated, open source database harboring 4543 therapeutically important ASP-siRNAs including 422 chemically modified ASP-siRNAs.
ASPsiPred is a two-layered algorithm for prediction of efficacy of ASP-siRNA for mutant and wild-type allele by ASPsiPredSVM and ASPsiPred Matrix respectively.
a) General fields: experimental information.
b) ASP-siRNA related fields: sequence,its efficacy to inhibit mutant and wild allele along with discrimination.
c) Disease/genetic/clinical information.