| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| aspsirna2049 | CUCUCCUGUAGCUAAAGCC GAGAGGACAUCGAUUUCGG |
62 | 45 | 17 | PPIB/Cyclophilin B | NA | NA | NA | 
|
|
| aspsirna3184 | CCGCACAGUUUCGACAUGU GGCGUGUCAAAGCUGUACA |
60 | 0 | 60 | TP63 | Ectrodactyly-Ectodermal Dysplasia-Clefting syndrome 3 (EEC3) | p.Arg132His,c.394G>A | rs19392114 |
|
|
| aspsirna1897 | GGGCCUGUGUCACCCUCAGGU CCCGGACACAGUGGGAGUCCA |
Moderate efficacy | Moderate efficacy | Poor discrimination | Myh6 | Human hypertrophic cardiomyopathy (HCM) | c.2384G>A,p.Arg795Gln | rs26760690 |
|
|
| aspsirna0598 | AGGAACUCAAUUCUCAGCU UCCUUGAGUUAAGAGUCGA |
82 | 50 | 32 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.488G>A,p.Arg163Gln | rs57758262 |
|
|
| aspsirna0331 | CCCAGGCUCCCAGGCAGGG GGGUCCGAGGGUCCGUCCC |
92 | 6 | 86 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0336 | AAGCCUGGUAUUCCCAGGC UUCGGACCAUAAGGGUCCG |
92 | 40 | 52 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0244 | GAGAUUGCUGACUACAGCA CUCUAACGACUGAUGUCGU |
2 | 55 | -53 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna0548 | AAGAUUGCUGACUACAGCA UUCUAACGACUGAUGUCGU |
40 | 0 | 40 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna3121 | GAUCAAGACCCUCAAAAAC CUAGUUCUGGGAGUUUUUG |
56 | 42 | 14 | KRT6A | Pachyonychia congenita (PC) | c.513C>A,p.Asn171Lys | rs59685571 |
|
|
| aspsirna0879 | GAUCAAGACCCUCAAAAAC CUAGUUCUGGGAGUUUUUG |
56 | 42 | 14 | KRT6a | Pachyonychia congenita (PC) | c.513C>A,p.Asn171Lys | rs59685571 |
|
|
| aspsirna3668 | GGUUGGAGGAGAGAUGAUA CCAACCUCCUCUCUAUUAU |
90 | 71 | 19 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
