| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| aspsirna3185 | CGCACAGUUUCGACAUGUC GCGUGUCAAAGCUGUACAG |
40 | 20 | 20 | TP63 | Ectrodactyly-Ectodermal Dysplasia-Clefting syndrome 3 (EEC3) | p.Arg132His,c.394G>A | rs19392114 | 
|
|
| aspsirna1898 | GGCCUGUGUCACCCUCAGGUG CCGGACACAGUGGGAGUCCAC |
Moderate efficacy | Moderate efficacy | Poor discrimination | Myh6 | Human hypertrophic cardiomyopathy (HCM) | c.2384G>A,p.Arg795Gln | rs26760690 |
|
|
| aspsirna0599 | GGAACUCAAUUCUCAGCUG CCUUGAGUUAAGAGUCGAC |
35 | 0 | 35 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.488G>A,p.Arg163Gln | rs57758262 |
|
|
| aspsirna0330 | UCCCAGGCUCCCAGGCAGG AGGGUCCGAGGGUCCGUCC |
24 | 10 | 14 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0245 | AGAUUGCUGACUACAGCAU UCUAACGACUGAUGUCGUA |
13 | 88 | -75 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna0547 | AGAUUGCUGACUACAGCAU UCUAACGACUGAUGUCGUA |
40 | 7 | 33 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna0880 | AUCAAGACCCUCAAAAACA UAGUUCUGGGAGUUUUUGU |
67 | 39 | 28 | KRT6a | Pachyonychia congenita (PC) | c.513C>A,p.Asn171Lys | rs59685571 |
|
|
| aspsirna3749 | AAAGUUGCGCGGAGGAGUU UUUCAACGCGCCUCUUCAA |
90 | 42 | 48 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
