| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| aspsirna3574 | AACAGUGGCUCACCAGAUU UUGUCACCGAGUGGUCUAA |
60 | 39 | 21 | ACVR1 | Fibrodysplasia Ossificans Progressiva (FOP) | c.617G>A,p.Arg206His | rs12191267 | 
|
|
| aspsirna2429 | AACUCCUCCGCACAACUUU UUGAGGAGGCGUGUUGAAA |
44 | 70 | -26 | KRAS | NA | NA | NA |
|
|
| aspsirna3188 | ACAGUUUCGACAUGUCCUU UGUCAAAGCUGUACAGGAA |
90 | 30 | 60 | TP63 | Ectrodactyly-Ectodermal Dysplasia-Clefting syndrome 3 (EEC3) | p.Arg132His,c.394G>A | rs19392114 |
|
|
| aspsirna2185 | AGGGAGAAGCCAGAGAUCC UCCCUCUUCGGUCUCUAGG |
50 | 10 | 40 | COL6A1 | Ullrich congenital muscular dystrophy (UCMD),Bethlem myopathy (BM) | c.850G>A, p.G284R | rs1219 |
|
|
| aspsirna1901 | CUGUGUCACCCUCAGGUGAGG GACACAGUGGGAGUCCACUCC |
Moderate efficacy | Moderate efficacy | Poor discrimination | Myh6 | Human hypertrophic cardiomyopathy (HCM) | c.2384G>A,p.Arg795Gln | rs26760690 |
|
|
| aspsirna0602 | ACUCAAUUCUCAGCUGGCC UGAGUUAAGAGUCGACCGG |
80 | 20 | 60 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.488G>A,p.Arg163Gln | rs57758262 |
|
|
| aspsirna0327 | UAUUCCCAGGCUCCCAGGC AUAAGGGUCCGAGGGUCCG |
88 | 20 | 68 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0248 | UUGCUGACUACAGCAUUGC AACGACUGAUGUCGUAACG |
30 | 20 | 10 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna0069 | CGACAGUGAUCAUCAUCAC GCUGUCACUAGUAGUAGUG |
45 | 55 | -10 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0093 | ACUUUGUGCACAACUGCGU UGAAACACGUGUUGACGCA |
82 | 93 | -11 | PRNP | Prion disease/Creutzfeldt-Jakob disease | c.532G>A,p.Asp178Asn | rs74315403 |
|
|
| aspsirna3508 | ACUUUGUGCACAACUGCGU UGAAACACGUGUUGACGCA |
82 | 93 | -11 | PRNP | Prion disease/Creutzfeldt-Jakob disease | c.532G>A,p.Asp178Asn | rs74315403 |
|
|
| aspsirna0883 | AAGACCCUCAAAAACAAGU UUCUGGGAGUUUUUGUUCA |
33 | 0 | 33 | KRT6a | Pachyonychia congenita (PC) | c.513C>A,p.Asn171Lys | rs59685571 |
|
|
| aspsirna3761 | AAAGUUGCGCGGAGGAGUU UUUCAACGCGCUUCCUCAA |
90 | 76 | 14 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
|
| aspsirna0200 | GUGGCCAGGUGAAAGUAAAAUC CACCGGUCCACUUUCAUUUUAG |
93 | 80 | 13 | MAPT | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | c.1960G>A,p.Val654Met | rs63750570 |
|
