| aspsirna3573 |
ACAGUGGCUCACCAGAUUA
UGUCACCGAGUGGUCUAAU |
50 |
20 |
30 |
ACVR1 |
Fibrodysplasia Ossificans Progressiva (FOP) |
c.617G>A,p.Arg206His |
rs12191267 |
|
US8859752B2 |
| aspsirna2064 |
CUCUCCUGUAACUAAGGCC
GAGAGGACAUUGAUUCCGG |
35 |
45 |
-10 |
PPIB/Cyclophilin B |
NA |
NA |
NA |
|
US2005/0176045A1 |
| aspsirna3189 |
CAGUUUCGACAUGUCCUUC
GUCAAAGCUGUACAGGAAG |
41 |
15 |
26 |
TP63 |
Ectrodactyly-Ectodermal Dysplasia-Clefting syndrome 3 (EEC3) |
p.Arg132His,c.394G>A |
rs19392114 |
|
26891374 |
| aspsirna2184 |
GGGAGAAGCCAGAGAUCCU
CCCUCUUCGGUCUCUAGGA |
80 |
70 |
10 |
COL6A1 |
Ullrich congenital muscular dystrophy (UCMD),Bethlem myopathy (BM) |
c.850G>A, p.G284R |
rs1219 |
|
24959844 |
| aspsirna1902 |
UGUGUCACCCUCAGGUGAGGG
ACACAGUGGGAGUCCACUCCC |
Moderate efficacy |
Moderate efficacy |
Poor discrimination |
Myh6 |
Human hypertrophic cardiomyopathy (HCM) |
c.2384G>A,p.Arg795Gln |
rs26760690 |
|
24092743 |
| aspsirna0603 |
CUCAAUUCUCAGCUGGCCU
GAGUUAAGAGUCGACCGGA |
61 |
0 |
61 |
KRT9 |
Epidermolytic palmoplantar keratoderma (EPPK) |
c.488G>A,p.Arg163Gln |
rs57758262 |
|
22402445 |
| aspsirna0326 |
GUAUUCCCAGGCUCCCAGG
CAUAAGGGUCCGAGGGUCC |
23 |
5 |
18 |
COL7A1 |
Dominant dystrophic epidermolysis bullosa(DDEB) |
c.6127G>A,p.Gly2043Arg |
rs12191283 |
|
22336946 |
| aspsirna0249 |
UGCUGACUACAGCAUUGCU
ACGACUGAUGUCGUAACGA |
55 |
50 |
5 |
LRRK2 |
Parkinsons disease (PD) |
c.6055G>A,p.Gly2019Ser |
rs34637584 |
|
22031823 |
| aspsirna0068 |
GACAGUGAUCAUCAUCACC
CUGUCACUAGUAGUAGUGG |
0 |
3 |
-3 |
APP |
Alzheimers disease |
c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) |
rs28186516 |
|
19771217 |
| aspsirna0092 |
CUUUGUGCACAACUGCGUC
GAAACACGUGUUGACGCAG |
75 |
92 |
-17 |
PRNP |
Prion disease/Creutzfeldt-Jakob disease |
c.532G>A,p.Asp178Asn |
rs74315403 |
|
18493311 |
| aspsirna3507 |
CUUUGUGCACAACUGCGUC
GAAACACGUGUUGACGCAG |
75 |
92 |
-17 |
PRNP |
Prion disease/Creutzfeldt-Jakob disease |
c.532G>A,p.Asp178Asn |
rs74315403 |
|
18493311 |
| aspsirna0884 |
AGACCCUCAAAAACAAGUU
UCUGGGAGUUUUUGUUCAA |
35 |
10 |
25 |
KRT6a |
Pachyonychia congenita (PC) |
c.513C>A,p.Asn171Lys |
rs59685571 |
|
17914454 |
| aspsirna3688 |
GGUUGGAGGAGAGAUGAUA
CCAACCUCCUUUCUACUAU |
90 |
59 |
31 |
PPIB/Cyclophilin B |
PPIB-Related Osteogenesis Imperfecta (Type IX) |
NA |
NA |
|
16489337 |
| aspsirna3765 |
AAAGUUGCGCGGAGGAGUU
UUUCAACGCGUCUCCUCAA |
90 |
33 |
57 |
PPIB/Cyclophilin B |
PPIB-Related Osteogenesis Imperfecta (Type IX) |
NA |
NA |
|
16489337 |
| aspsirna1793 |
CAAUGUGGCCAUGCAUGUG
GUUACACCGGUACGUACAC |
NA |
65 |
NA |
TTR |
Amyloidogenic transthyretin amyloidosis |
c.148G>A,p.Val50Met |
rs28933979 |
|
16225852 |
| aspsirna1822 |
AAGCAGCACAAUAAUGAGUGC
UUCGUCGUGUUAUUACUCACG |
NA |
23 |
NA |
Fen1 |
Werner syndrome |
NA |
NA |
|
16113241 |
