Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              18    1482
NP_001035957                                                           18    1482
XP_006721990                                                           18    1482
XP_006721989                                                           18    1482
XP_005258041                                                           18    1482
XP_006721988                                                           18    1482
XP_006721987                                                           18    1482
XP_006721986                                                           18    1482
XP_005258040                                                           18    1482
XP_006721985                                                           18    1482
NP_001005327                                                           17    4312
NP_001005279                                                           16    5631
NP_006412                                                              16    7355
NP_006411                                                              16    7355
XP_006723746                                                           16    7355
XP_005260309                                                           16    7355
XP_006719806                                                           16    7355
XP_006716481                                                           16    7355
XP_005251193                                                           16    7355
XP_005251192                                                           16    7355
XP_005251191                                                           16    7355
NP_002145                                                              15    9605
NP_005637                                                              15    9605
NP_055093                                                              15    9605
NP_722518                                                              15    9605
NP_001166173                                                           15    9605
NP_001399                                                              15    9605
XP_006720113                                                           15    9605
XP_006720112                                                           15    9605
XP_006720111                                                           15    9605
XP_006720110                                                           15    9605
XP_006720109                                                           15    9605
XP_006714203                                                           15    9605
XP_005273291                                                           15    9605
XP_006710468                                                           15    9605
XP_005270637                                                           15    9605
>NP_000258
          Length = 2818

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ADTAVALA 8
            ADTAVALA
Sbjct: 2011 ADTAVALA 2018
>NP_001035957
          Length = 2839

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ADTAVALA 8
            ADTAVALA
Sbjct: 2032 ADTAVALA 2039
>XP_006721990
          Length = 2823

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ADTAVALA 8
            ADTAVALA
Sbjct: 2042 ADTAVALA 2049
>XP_006721989
          Length = 2823

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ADTAVALA 8
            ADTAVALA
Sbjct: 2042 ADTAVALA 2049
>XP_005258041
          Length = 2836

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ADTAVALA 8
            ADTAVALA
Sbjct: 2011 ADTAVALA 2018
>XP_006721988
          Length = 2846

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ADTAVALA 8
            ADTAVALA
Sbjct: 2021 ADTAVALA 2028
>XP_006721987
          Length = 2849

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ADTAVALA 8
            ADTAVALA
Sbjct: 2042 ADTAVALA 2049
>XP_006721986
          Length = 2854

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ADTAVALA 8
            ADTAVALA
Sbjct: 2029 ADTAVALA 2036
>XP_005258040
          Length = 2857

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ADTAVALA 8
            ADTAVALA
Sbjct: 2032 ADTAVALA 2039
>XP_006721985
          Length = 2867

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ADTAVALA 8
            ADTAVALA
Sbjct: 2042 ADTAVALA 2049
>NP_001005327
          Length = 315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DTAVALAF 9
           DTA+AL F
Sbjct: 270 DTAIALMF 277
>NP_001005279
          Length = 324

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DTAVALAF 9
           D A+ALAF
Sbjct: 272 DIAIALAF 279
>NP_006412
          Length = 1849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTAVALAF 9
           ADTA  LA+
Sbjct: 821 ADTAYVLAY 829
>NP_006411
          Length = 1785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTAVALAF 9
           ADTA  LA+
Sbjct: 766 ADTAYVLAY 774
>XP_006723746
          Length = 1177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTAVALAF 9
           ADTA  LA+
Sbjct: 158 ADTAYVLAY 166
>XP_005260309
          Length = 1784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTAVALAF 9
           ADTA  LA+
Sbjct: 765 ADTAYVLAY 773
>XP_006719806
          Length = 492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ADTAVALA 8
           ADTAVA++
Sbjct: 360 ADTAVAVS 367
>XP_006716481
          Length = 1649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTAVALAF 9
           ADTA  LA+
Sbjct: 621 ADTAYVLAY 629
>XP_005251193
          Length = 1800

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTAVALAF 9
           ADTA  LA+
Sbjct: 821 ADTAYVLAY 829
>XP_005251192
          Length = 1843

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTAVALAF 9
           ADTA  LA+
Sbjct: 821 ADTAYVLAY 829
>XP_005251191
          Length = 1849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADTAVALAF 9
           ADTA  LA+
Sbjct: 821 ADTAYVLAY 829
>NP_002145
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TAVALAF 9
           TAVALA+
Sbjct: 175 TAVALAY 181
>NP_005637
          Length = 1621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ADTAVALA 8
           A TAVALA
Sbjct: 164 AGTAVALA 171
>NP_055093
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TAVALAF 9
           TAVALA+
Sbjct: 175 TAVALAY 181
>NP_722518
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DTAVALAF 9
           +TA+AL+F
Sbjct: 286 NTAIALSF 293
>NP_001166173
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DTAVALAF 9
           +TA+AL+F
Sbjct: 286 NTAIALSF 293
>NP_001399
          Length = 2923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    DTAVALAF 9
            DT VAL F
Sbjct: 1488 DTGVALRF 1495
>XP_006720113
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  DTAVALAF 9
          +TA+AL+F
Sbjct: 85 NTAIALSF 92
>XP_006720112
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DTAVALAF 9
           +TA+AL+F
Sbjct: 286 NTAIALSF 293
>XP_006720111
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DTAVALAF 9
           +TA+AL+F
Sbjct: 232 NTAIALSF 239
>XP_006720110
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DTAVALAF 9
           +TA+AL+F
Sbjct: 263 NTAIALSF 270
>XP_006720109
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DTAVALAF 9
           +TA+AL+F
Sbjct: 268 NTAIALSF 275
>XP_006714203
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TAVALAF 9
           TAVALA+
Sbjct: 175 TAVALAY 181
>XP_005273291
          Length = 1620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ADTAVALA 8
           A TAVALA
Sbjct: 164 AGTAVALA 171
>XP_006710468
          Length = 2916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    DTAVALAF 9
            DT VAL F
Sbjct: 1488 DTGVALRF 1495
>XP_005270637
          Length = 2921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    DTAVALAF 9
            DT VAL F
Sbjct: 1488 DTGVALRF 1495
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.127    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 264,434
Number of extensions: 302
Number of successful extensions: 36
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 36
Number of HSP's successfully gapped: 36
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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