Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1482
NP_001075109                                                           18    1482
NP_055178                                                              17    2528
NP_001264984                                                           17    2528
XP_005266395                                                           17    2528
NP_001129246                                                           17    4312
NP_003481                                                              17    4312
NP_598344                                                              17    4312
NP_803875                                                              17    4312
NP_071410                                                              16    7355
NP_001186562                                                           16    7355
NP_002630                                                              16    7355
NP_001017403                                                           16    7355
NP_996920                                                              16    7355
NP_067649                                                              16    7355
NP_001017404                                                           16    7355
NP_996919                                                              16    7355
NP_001026                                                              16    7355
NP_065140                                                              16    7355
NP_001243325                                                           16    7355
NP_001243324                                                           16    7355
NP_112592                                                              16    7355
XP_005254670                                                           16    7355
XP_006720721                                                           16    7355
XP_005269228                                                           16    7355
XP_006711873                                                           16    7355
XP_006711872                                                           16    7355
XP_006711871                                                           16    7355
XP_006711870                                                           16    7355
XP_006711869                                                           16    7355
XP_006711868                                                           16    7355
XP_006711867                                                           16    7355
XP_006711866                                                           16    7355
XP_006711865                                                           16    7355
XP_006711543                                                           16    7355
XP_005245461                                                           16    7355
NP_001264156                                                           15    9605
NP_003658                                                              15    9605
NP_001264155                                                           15    9605
NP_004843                                                              15    9605
NP_079007                                                              15    9605
NP_057179                                                              15    9605
NP_055214                                                              15    9605
XP_005256206                                                           15    9605
XP_005269261                                                           15    9605
NP_115536                                                              15    9605
>NP_008835
          Length = 4128

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ALNSLYSLK 9
            ALNSLYS K
Sbjct: 2541 ALNSLYSPK 2549
>NP_001075109
          Length = 4097

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ALNSLYSLK 9
            ALNSLYS K
Sbjct: 2541 ALNSLYSPK 2549
>NP_055178
          Length = 4579

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    ALNSLYSLK 9
            ALN LYS+K
Sbjct: 2758 ALNVLYSVK 2766
>NP_001264984
          Length = 4432

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    ALNSLYSLK 9
            ALN LYS+K
Sbjct: 2611 ALNVLYSVK 2619
>XP_005266395
          Length = 4588

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    ALNSLYSLK 9
            ALN LYS+K
Sbjct: 2767 ALNVLYSVK 2775
>NP_001129246
          Length = 579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ALNSLYSL 8
           A+NSLYS+
Sbjct: 190 AVNSLYSV 197
>NP_003481
          Length = 580

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ALNSLYSL 8
           A+NSLYS+
Sbjct: 191 AVNSLYSV 198
>NP_598344
          Length = 444

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ALNSLYSL 8
           A+NSLYS+
Sbjct: 191 AVNSLYSV 198
>NP_803875
          Length = 4243

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALNSLYSLK 9
           ALN L+S+K
Sbjct: 571 ALNDLWSIK 579
>NP_071410
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSLYSLK 9
           +SLYSLK
Sbjct: 665 HSLYSLK 671
>NP_001186562
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSLYSLK 9
           +SLYSLK
Sbjct: 665 HSLYSLK 671
>NP_002630
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LNSLYSLK 9
          L+S YSLK
Sbjct: 80 LSSFYSLK 87
>NP_001017403
          Length = 967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ALNSLYSLK 9
           A + LYSLK
Sbjct: 109 AFSGLYSLK 117
>NP_996920
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSLYSLK 9
           NSL+SLK
Sbjct: 391 NSLHSLK 397
>NP_067649
          Length = 915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ALNSLYSLK 9
          A + LYSLK
Sbjct: 57 AFSGLYSLK 65
>NP_001017404
          Length = 828

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ALNSLYSLK 9
          A + LYSLK
Sbjct: 66 AFSGLYSLK 74
>NP_996919
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSLYSLK 9
           NSL+SLK
Sbjct: 391 NSLHSLK 397
>NP_001026
          Length = 4967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LNSLYSL 8
           LNSLY L
Sbjct: 530 LNSLYEL 536
>NP_065140
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ALNSLYSL 8
           ALN+ YSL
Sbjct: 251 ALNTYYSL 258
>NP_001243325
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ALNSLYSL 8
           ALN+ YSL
Sbjct: 221 ALNTYYSL 228
>NP_001243324
          Length = 389

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ALNSLYSL 8
           ALN+ YSL
Sbjct: 182 ALNTYYSL 189
>NP_112592
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  ALNSLYS 7
          A+NS+YS
Sbjct: 68 AINSIYS 74
>XP_005254670
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSLYSLK 9
           NSL+SLK
Sbjct: 333 NSLHSLK 339
>XP_006720721
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSLYSLK 9
           NSL+SLK
Sbjct: 391 NSLHSLK 397
>XP_005269228
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  ALNSLYS 7
          A+NS+YS
Sbjct: 68 AINSIYS 74
>XP_006711873
          Length = 4954

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LNSLYSL 8
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711872
          Length = 2735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LNSLYSL 8
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711871
          Length = 4906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LNSLYSL 8
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711870
          Length = 4965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LNSLYSL 8
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711869
          Length = 4973

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LNSLYSL 8
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711868
          Length = 4975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LNSLYSL 8
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711867
          Length = 4977

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LNSLYSL 8
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711866
          Length = 4984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LNSLYSL 8
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711865
          Length = 4985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LNSLYSL 8
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711543
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ALNSLYSLK 9
           A + LYSLK
Sbjct: 109 AFSGLYSLK 117
>XP_005245461
          Length = 924

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ALNSLYSLK 9
          A + LYSLK
Sbjct: 66 AFSGLYSLK 74
>NP_001264156
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ALNSLYSLK 9
           A   LYSLK
Sbjct: 109 AFTGLYSLK 117
>NP_003658
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ALNSLYSLK 9
           A   LYSLK
Sbjct: 109 AFTGLYSLK 117
>NP_001264155
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ALNSLYSLK 9
           A   LYSLK
Sbjct: 109 AFTGLYSLK 117
>NP_004843
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALNSLYS 7
           A+N+LYS
Sbjct: 206 AMNNLYS 212
>NP_079007
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LNSLYSLK 9
           L S+YSLK
Sbjct: 154 LASIYSLK 161
>NP_057179
          Length = 185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ALNSLYSLK 9
           ALN +Y L+
Sbjct: 163 ALNHMYKLR 171
>NP_055214
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ALNSLYSL 8
          ALN LY+L
Sbjct: 15 ALNLLYTL 22
>XP_005256206
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LNSLYSLK 9
           L S+YSLK
Sbjct: 154 LASIYSLK 161
>XP_005269261
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  ALNSLYSLK 9
          A   LYSLK
Sbjct: 35 AFTGLYSLK 43
>NP_115536
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SLYSLK 9
            SLYSLK
Sbjct: 1057 SLYSLK 1062
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.124    0.304 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 446,099
Number of extensions: 646
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package