Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1482
NP_001075109                                                           18    1482
NP_003909                                                              16    7355
NP_001171632                                                           16    7355
NP_060474                                                              16    7355
XP_006724585                                                           16    7355
XP_006724584                                                           16    7355
XP_005274676                                                           16    7355
XP_005274674                                                           16    7355
XP_005274675                                                           16    7355
XP_005247626                                                           16    7355
XP_005247625                                                           16    7355
NP_001093226                                                           15    9605
NP_001093225                                                           15    9605
NP_001093223                                                           15    9605
NP_001093224                                                           15    9605
NP_001093222                                                           15    9605
NP_001093221                                                           15    9605
NP_001093220                                                           15    9605
NP_001093219                                                           15    9605
NP_001093217                                                           15    9605
NP_001093216                                                           15    9605
NP_001093215                                                           15    9605
NP_001093214                                                           15    9605
NP_001093213                                                           15    9605
NP_443111                                                              15    9605
NP_060256                                                              15    9605
NP_954660                                                              15    9605
NP_954658                                                              15    9605
NP_001164274                                                           15    9605
XP_006719279                                                           15    9605
XP_005268670                                                           15    9605
XP_006719278                                                           15    9605
XP_005251057                                                           15    9605
XP_005251056                                                           15    9605
XP_006716664                                                           15    9605
XP_006716663                                                           15    9605
NP_001164275                                                           15    9605
NP_001164279                                                           15    9605
NP_001093218                                                           15    9605
>NP_008835
          Length = 4128

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AVLELMRSS 9
            AVLELM+SS
Sbjct: 1578 AVLELMQSS 1586
>NP_001075109
          Length = 4097

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AVLELMRSS 9
            AVLELM+SS
Sbjct: 1578 AVLELMQSS 1586
>NP_003909
          Length = 501

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVLELMRSS 9
          A LEL+RSS
Sbjct: 12 AGLELLRSS 20
>NP_001171632
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVLELMRSS 9
          A LEL+RSS
Sbjct: 12 AGLELLRSS 20
>NP_060474
          Length = 275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VLELMRSS 9
           +LEL+RSS
Sbjct: 178 LLELLRSS 185
>XP_006724585
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVLELMRSS 9
          A LEL+RSS
Sbjct: 10 AGLELLRSS 18
>XP_006724584
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVLELMRSS 9
          A LEL+RSS
Sbjct: 12 AGLELLRSS 20
>XP_005274676
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVLELMRSS 9
          A LEL+RSS
Sbjct: 12 AGLELLRSS 20
>XP_005274674
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVLELMRSS 9
          A LEL+RSS
Sbjct: 12 AGLELLRSS 20
>XP_005274675
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVLELMRSS 9
          A LEL+RSS
Sbjct: 12 AGLELLRSS 20
>XP_005247626
          Length = 291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VLELMRSS 9
           +LEL+RSS
Sbjct: 194 LLELLRSS 201
>XP_005247625
          Length = 291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VLELMRSS 9
           +LEL+RSS
Sbjct: 194 LLELLRSS 201
>NP_001093226
          Length = 660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 337 VIETMRSS 344
>NP_001093225
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 221 VIETMRSS 228
>NP_001093223
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 339 VIETMRSS 346
>NP_001093224
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 340 VIETMRSS 347
>NP_001093222
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 340 VIETMRSS 347
>NP_001093221
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 339 VIETMRSS 346
>NP_001093220
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 340 VIETMRSS 347
>NP_001093219
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 221 VIETMRSS 228
>NP_001093217
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 339 VIETMRSS 346
>NP_001093216
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 221 VIETMRSS 228
>NP_001093215
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 340 VIETMRSS 347
>NP_001093214
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 340 VIETMRSS 347
>NP_001093213
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 339 VIETMRSS 346
>NP_443111
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLELMRSS 9
           +LE++RSS
Sbjct: 173 ILEVLRSS 180
>NP_060256
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 339 VIETMRSS 346
>NP_954660
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLELMRSS 9
           +LE++RSS
Sbjct: 173 ILEVLRSS 180
>NP_954658
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLELMRSS 9
           +LE++RSS
Sbjct: 172 ILEVLRSS 179
>NP_001164274
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLELMRSS 9
           +LE++RSS
Sbjct: 173 ILEVLRSS 180
>XP_006719279
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLELMRSS 9
           +LE++RSS
Sbjct: 173 ILEVLRSS 180
>XP_005268670
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLELMRSS 9
           +LE++RSS
Sbjct: 103 ILEVLRSS 110
>XP_006719278
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLELMRSS 9
           +LE++RSS
Sbjct: 173 ILEVLRSS 180
>XP_005251057
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 177 VIETMRSS 184
>XP_005251056
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 210 VIETMRSS 217
>XP_006716664
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 299 VIETMRSS 306
>XP_006716663
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 446 VIETMRSS 453
>NP_001164275
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLELMRSS 9
           +LE++RSS
Sbjct: 173 ILEVLRSS 180
>NP_001164279
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLELMRSS 9
           +LE++RSS
Sbjct: 173 ILEVLRSS 180
>NP_001093218
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLELMRSS 9
           V+E MRSS
Sbjct: 340 VIETMRSS 347
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.123    0.272 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 308,175
Number of extensions: 346
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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