Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              21     175
XP_005271970                                                           17    3301
NP_001193934                                                           17    4312
NP_861421                                                              17    4312
NP_006506                                                              16    5631
NP_001263254                                                           16    5631
XP_006713359                                                           16    5631
NP_001025006                                                           16    7355
NP_113631                                                              16    7355
NP_001161407                                                           16    7355
NP_001161406                                                           16    7355
NP_997698                                                              16    7355
NP_001597                                                              16    7355
XP_005253558                                                           16    7355
XP_006719219                                                           16    7355
XP_005253556                                                           16    7355
XP_005253555                                                           16    7355
XP_006717059                                                           16    7355
XP_006715849                                                           16    7355
XP_006715848                                                           16    7355
NP_009109                                                              15    9605
NP_001273167                                                           15    9605
NP_001276062                                                           15    9605
NP_061946                                                              15    9605
NP_001273168                                                           15    9605
NP_001002860                                                           15    9605
NP_001107644                                                           15    9605
NP_001107604                                                           15    9605
NP_001027545                                                           15    9605
NP_003620                                                              15    9605
XP_006725229                                                           15    9605
XP_005259285                                                           15    9605
XP_006723432                                                           15    9605
XP_006723431                                                           15    9605
XP_005259284                                                           15    9605
XP_006723430                                                           15    9605
XP_005259283                                                           15    9605
XP_005259282                                                           15    9605
XP_005259281                                                           15    9605
XP_006720258                                                           15    9605
XP_005253351                                                           15    9605
XP_006712765                                                           15    9605
XP_006712764                                                           15    9605
XP_005246844                                                           15    9605
XP_006712763                                                           15    9605
XP_006712762                                                           15    9605
XP_006712761                                                           15    9605
XP_005271347                                                           15    9605
XP_006710764                                                           15    9605
XP_006710762                                                           15    9605
XP_005271005                                                           15    9605
NP_001027544                                                           15    9605
>NP_055365
          Length = 1032

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DENYMITMR 9
           DENYMI MR
Sbjct: 204 DENYMIAMR 212
>XP_005271970
          Length = 2931

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    NYMITMR 9
            NYMIT R
Sbjct: 2906 NYMITFR 2912
>NP_001193934
          Length = 670

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DENYMITMR 9
           DENY+I ++
Sbjct: 154 DENYVIKLQ 162
>NP_861421
          Length = 670

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DENYMITMR 9
           DENY+I ++
Sbjct: 154 DENYVIKLQ 162
>NP_006506
          Length = 684

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DENYMITMR 9
           D NY+I +R
Sbjct: 189 DSNYIIAIR 197
>NP_001263254
          Length = 365

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DENYMITMR 9
           D NY+I +R
Sbjct: 189 DSNYIIAIR 197
>XP_006713359
          Length = 370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DENYMITMR 9
           D NY+I +R
Sbjct: 189 DSNYIIAIR 197
>NP_001025006
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ENYMITMR 9
           ++YM+T+R
Sbjct: 321 QDYMLTLR 328
>NP_113631
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ENYMITMR 9
           ++YM+T+R
Sbjct: 300 QDYMLTLR 307
>NP_001161407
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ENYMITMR 9
           ++YM+T+R
Sbjct: 209 QDYMLTLR 216
>NP_001161406
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ENYMITMR 9
           ++YM+T+R
Sbjct: 242 QDYMLTLR 249
>NP_997698
          Length = 2466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    ENYMITMR 9
            + YMIT+R
Sbjct: 2309 DGYMITVR 2316
>NP_001597
          Length = 2436

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    ENYMITMR 9
            + YMIT+R
Sbjct: 2279 DGYMITVR 2286
>XP_005253558
          Length = 897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   DENYMITMR 9
           + N+++TMR
Sbjct: 251 NRNFLLTMR 259
>XP_006719219
          Length = 910

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   DENYMITMR 9
           + N+++TMR
Sbjct: 320 NRNFLLTMR 328
>XP_005253556
          Length = 944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   DENYMITMR 9
           + N+++TMR
Sbjct: 320 NRNFLLTMR 328
>XP_005253555
          Length = 966

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   DENYMITMR 9
           + N+++TMR
Sbjct: 320 NRNFLLTMR 328
>XP_006717059
          Length = 2435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    ENYMITMR 9
            + YMIT+R
Sbjct: 2278 DGYMITVR 2285
>XP_006715849
          Length = 374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ENYMITMR 9
           ++YM+T+R
Sbjct: 230 QDYMLTLR 237
>XP_006715848
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ENYMITMR 9
           ++YM+T+R
Sbjct: 263 QDYMLTLR 270
>NP_009109
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   DENYMIT 7
           D NY++T
Sbjct: 111 DSNYLLT 117
>NP_001273167
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DENYMITMR 9
           D N  +TMR
Sbjct: 121 DSNRQVTMR 129
>NP_001276062
          Length = 781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DENYMITMR 9
           DE+ ++TMR
Sbjct: 369 DESPLLTMR 377
>NP_061946
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DENYMITMR 9
           D N  +TMR
Sbjct: 121 DSNRQVTMR 129
>NP_001273168
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DENYMITMR 9
           D N  +TMR
Sbjct: 107 DSNRQVTMR 115
>NP_001002860
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DENYMITMR 9
           DE+ ++TMR
Sbjct: 720 DESPLLTMR 728
>NP_001107644
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   DENYMI 6
           DENY I
Sbjct: 338 DENYFI 343
>NP_001107604
          Length = 2694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NYMITM 8
           NY+ITM
Sbjct: 117 NYVITM 122
>NP_001027545
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   DENYMI 6
           DENY++
Sbjct: 145 DENYIV 150
>NP_003620
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   DENYMI 6
           DENY I
Sbjct: 338 DENYFI 343
>XP_006725229
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DENYMITMR 9
           DE+ ++TMR
Sbjct: 720 DESPLLTMR 728
>XP_005259285
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   DENYMI 6
           DENY++
Sbjct: 145 DENYIV 150
>XP_006723432
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   DENYMI 6
           DENY++
Sbjct: 145 DENYIV 150
>XP_006723431
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   DENYMI 6
           DENY++
Sbjct: 145 DENYIV 150
>XP_005259284
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   DENYMI 6
           DENY++
Sbjct: 145 DENYIV 150
>XP_006723430
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   DENYMI 6
           DENY++
Sbjct: 145 DENYIV 150
>XP_005259283
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   DENYMI 6
           DENY++
Sbjct: 145 DENYIV 150
>XP_005259282
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   DENYMI 6
           DENY++
Sbjct: 145 DENYIV 150
>XP_005259281
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   DENYMI 6
           DENY++
Sbjct: 145 DENYIV 150
>XP_006720258
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DENYMITMR 9
           DE+ ++TMR
Sbjct: 720 DESPLLTMR 728
>XP_005253351
          Length = 256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  DENYMIT 7
          D NY++T
Sbjct: 17 DSNYLLT 23
>XP_006712765
          Length = 2679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NYMITM 8
           NY+ITM
Sbjct: 117 NYVITM 122
>XP_006712764
          Length = 2697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NYMITM 8
           NY+ITM
Sbjct: 117 NYVITM 122
>XP_005246844
          Length = 2707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NYMITM 8
           NY+ITM
Sbjct: 117 NYVITM 122
>XP_006712763
          Length = 2716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NYMITM 8
           NY+ITM
Sbjct: 117 NYVITM 122
>XP_006712762
          Length = 2723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NYMITM 8
           NY+ITM
Sbjct: 117 NYVITM 122
>XP_006712761
          Length = 2736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NYMITM 8
           NY+ITM
Sbjct: 117 NYVITM 122
>XP_005271347
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   DENYMI 6
           DENY I
Sbjct: 355 DENYFI 360
>XP_006710764
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DENYMITMR 9
           D N  +TMR
Sbjct: 121 DSNRQVTMR 129
>XP_006710762
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DENYMITMR 9
           D N  +TMR
Sbjct: 121 DSNRQVTMR 129
>XP_005271005
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DENYMITMR 9
           D N  +TMR
Sbjct: 121 DSNRQVTMR 129
>NP_001027544
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   DENYMI 6
           DENY++
Sbjct: 145 DENYIV 150
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.133    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 477,488
Number of extensions: 733
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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