Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              18    1135
NP_001276866                                                           18    1482
NP_004439                                                              18    1482
NP_001276865                                                           18    1482
NP_001005862                                                           18    1482
XP_005257197                                                           18    1482
XP_006721828                                                           18    1482
NP_001036064                                                           17    3301
NP_005226                                                              17    3301
XP_005246434                                                           17    3301
XP_005246433                                                           17    3301
XP_005246432                                                           17    3301
XP_006712427                                                           17    3301
NP_001137307                                                           17    4312
NP_006156                                                              17    4312
NP_060220                                                              17    4312
XP_005271626                                                           17    4312
XP_005271625                                                           17    4312
XP_005271624                                                           17    4312
XP_005271623                                                           17    4312
XP_005271622                                                           17    4312
NP_057232                                                              16    5631
XP_006723297                                                           16    5631
XP_006723296                                                           16    5631
XP_005259020                                                           16    5631
XP_006720120                                                           16    5631
XP_006720119                                                           16    5631
NP_689659                                                              16    5631
NP_001121685                                                           16    7355
NP_001121684                                                           16    7355
XP_006712405                                                           16    7355
XP_006712404                                                           16    7355
XP_005246413                                                           16    7355
NP_689741                                                              16    7355
NP_005859                                                              16    7355
NP_001030025                                                           15    9605
NP_000319                                                              15    9605
NP_001274420                                                           15    9605
NP_001185882                                                           15    9605
NP_076976                                                              15    9605
XP_005272690                                                           15    9605
XP_006724601                                                           15    9605
XP_005271739                                                           15    9605
XP_005250117                                                           15    9605
XP_005264244                                                           15    9605
NP_003469                                                              15    9605
NP_003583                                                              15    9605
>NP_005219
          Length = 1210

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           KIKVL SGA
Sbjct: 714 KIKVLGSGA 722
>NP_001276866
          Length = 1055

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           K+KVL SGA
Sbjct: 722 KVKVLGSGA 730
>NP_004439
          Length = 1255

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           K+KVL SGA
Sbjct: 722 KVKVLGSGA 730
>NP_001276865
          Length = 1240

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           K+KVL SGA
Sbjct: 707 KVKVLGSGA 715
>NP_001005862
          Length = 1225

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           K+KVL SGA
Sbjct: 692 KVKVLGSGA 700
>XP_005257197
          Length = 1225

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           K+KVL SGA
Sbjct: 692 KVKVLGSGA 700
>XP_006721828
          Length = 1336

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           K+KVL SGA
Sbjct: 803 KVKVLGSGA 811
>NP_001036064
          Length = 1292

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           ++KVL SGA
Sbjct: 720 RVKVLGSGA 728
>NP_005226
          Length = 1308

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           ++KVL SGA
Sbjct: 720 RVKVLGSGA 728
>XP_005246434
          Length = 1282

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           ++KVL SGA
Sbjct: 710 RVKVLGSGA 718
>XP_005246433
          Length = 1298

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           ++KVL SGA
Sbjct: 710 RVKVLGSGA 718
>XP_005246432
          Length = 1307

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           ++KVL SGA
Sbjct: 735 RVKVLGSGA 743
>XP_006712427
          Length = 1323

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           ++KVL SGA
Sbjct: 735 RVKVLGSGA 743
>NP_001137307
          Length = 1299

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   IKVLSSG 8
           IKVLSSG
Sbjct: 695 IKVLSSG 701
>NP_006156
          Length = 1324

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   IKVLSSG 8
           IKVLSSG
Sbjct: 720 IKVLSSG 726
>NP_060220
          Length = 610

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IKVLSSGA 9
           +KV+SSGA
Sbjct: 198 VKVVSSGA 205
>XP_005271626
          Length = 1294

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   IKVLSSG 8
           IKVLSSG
Sbjct: 779 IKVLSSG 785
>XP_005271625
          Length = 1311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   IKVLSSG 8
           IKVLSSG
Sbjct: 707 IKVLSSG 713
>XP_005271624
          Length = 1311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   IKVLSSG 8
           IKVLSSG
Sbjct: 707 IKVLSSG 713
>XP_005271623
          Length = 1371

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   IKVLSSG 8
           IKVLSSG
Sbjct: 767 IKVLSSG 773
>XP_005271622
          Length = 1383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   IKVLSSG 8
           IKVLSSG
Sbjct: 779 IKVLSSG 785
>NP_057232
          Length = 2161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           KIKVLS G
Sbjct: 580 KIKVLSIG 587
>XP_006723297
          Length = 2152

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           KIKVLS G
Sbjct: 580 KIKVLSIG 587
>XP_006723296
          Length = 2161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           KIKVLS G
Sbjct: 580 KIKVLSIG 587
>XP_005259020
          Length = 2169

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           KIKVLS G
Sbjct: 580 KIKVLSIG 587
>XP_006720120
          Length = 1055

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           K+KV SSG
Sbjct: 810 KLKVFSSG 817
>XP_006720119
          Length = 1094

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           K+KV SSG
Sbjct: 849 KLKVFSSG 856
>NP_689659
          Length = 1094

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           K+KV SSG
Sbjct: 849 KLKVFSSG 856
>NP_001121685
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           K+K LSSG
Sbjct: 396 KVKSLSSG 403
>NP_001121684
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           K+K LSSG
Sbjct: 396 KVKSLSSG 403
>XP_006712405
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           K+K LSSG
Sbjct: 158 KVKSLSSG 165
>XP_006712404
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           K+K LSSG
Sbjct: 227 KVKSLSSG 234
>XP_005246413
          Length = 384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           K+K LSSG
Sbjct: 304 KVKSLSSG 311
>NP_689741
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KIKVLSSG 8
           K+K LSSG
Sbjct: 396 KVKSLSSG 403
>NP_005859
          Length = 118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KIKVLSSGA 9
          K+K+LS G+
Sbjct: 84 KLKILSRGS 92
>NP_001030025
          Length = 1152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           KIK LS+G+
Sbjct: 141 KIKQLSAGS 149
>NP_000319
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           KIK LS+G+
Sbjct: 141 KIKQLSAGS 149
>NP_001274420
          Length = 1795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           +IK+ SSGA
Sbjct: 756 QIKIESSGA 764
>NP_001185882
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           ++KVL SGA
Sbjct: 113 QLKVLLSGA 121
>NP_076976
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           ++KVL SGA
Sbjct: 113 QLKVLLSGA 121
>XP_005272690
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           KIK LS+G+
Sbjct: 141 KIKQLSAGS 149
>XP_006724601
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           KIK LS+G+
Sbjct: 141 KIKQLSAGS 149
>XP_005271739
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IKVLSSGA 9
           IK+L++GA
Sbjct: 469 IKILNAGA 476
>XP_005250117
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IKVLSSGA 9
           I+VLSSG+
Sbjct: 537 IQVLSSGS 544
>XP_005264244
          Length = 1795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KIKVLSSGA 9
           +IK+ SSGA
Sbjct: 756 QIKIESSGA 764
>NP_003469
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IKVLSSGA 9
           IK+L++GA
Sbjct: 528 IKILNAGA 535
>NP_003583
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IKVLSSGA 9
           I+VLSSG+
Sbjct: 537 IQVLSSGS 544
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.123    0.289 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 418,897
Number of extensions: 580
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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