Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
NP_065829                                                              18    1135
NP_006022                                                              18    1482
XP_005261186                                                           18    1482
XP_005261185                                                           18    1482
XP_005261184                                                           18    1482
XP_005261183                                                           18    1482
XP_005261182                                                           18    1482
XP_005261181                                                           18    1482
NP_004813                                                              17    2528
XP_006721658                                                           17    2528
XP_005268711                                                           17    2528
NP_057200                                                              17    2528
NP_077000                                                              17    2528
NP_570843                                                              17    3301
NP_001128529                                                           17    3301
NP_001277026                                                           17    4312
NP_001139808                                                           17    4312
NP_079133                                                              16    5631
NP_861420                                                              16    5631
NP_005516                                                              16    5631
NP_001193670                                                           16    5631
NP_001241872                                                           16    5631
NP_001129069                                                           16    5631
NP_060554                                                              16    5631
NP_056526                                                              16    5631
XP_006723243                                                           16    5631
XP_005258890                                                           16    5631
XP_005264484                                                           16    5631
XP_005264483                                                           16    5631
XP_005264480                                                           16    5631
XP_005264478                                                           16    5631
XP_005264475                                                           16    5631
NP_085135                                                              16    7355
NP_001265524                                                           16    7355
NP_877577                                                              16    7355
NP_005907                                                              16    7355
NP_112170                                                              16    7355
XP_006726516                                                           16    7355
XP_005258413                                                           16    7355
XP_005250405                                                           16    7355
XP_006714534                                                           16    7355
NP_001004488                                                           16    7355
NP_787117                                                              16    7355
NP_001005328                                                           16    7355
NP_005090                                                              15    9605
NP_001073883                                                           15    9605
NP_001982                                                              15    9605
XP_005257203                                                           15    9605
XP_005257202                                                           15    9605
XP_005257201                                                           15    9605
XP_005267748                                                           15    9605
XP_006711698                                                           15    9605
NP_001180264                                                           15    9605
NP_543140                                                              15    9605
NP_060150                                                              15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    KKYLLLLL 9
            KKYLLLLL
Sbjct: 3719 KKYLLLLL 3726
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    KKYLLLLL 9
            KKYLLLLL
Sbjct: 3711 KKYLLLLL 3718
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    KKYLLLLL 9
            KKYLLLLL
Sbjct: 3672 KKYLLLLL 3679
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    KKYLLLLL 9
            KKYLLLLL
Sbjct: 3751 KKYLLLLL 3758
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    KKYLLLLL 9
            KKYLLLLL
Sbjct: 3764 KKYLLLLL 3771
>NP_065829
          Length = 1907

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LKKYLLLLL 9
            LK YLLLLL
Sbjct: 1162 LKNYLLLLL 1170
>NP_006022
          Length = 3336

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    KKYLLLLL 9
            KKYLLLL+
Sbjct: 3153 KKYLLLLI 3160
>XP_005261186
          Length = 3139

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    KKYLLLLL 9
            KKYLLLL+
Sbjct: 2956 KKYLLLLI 2963
>XP_005261185
          Length = 3229

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    KKYLLLLL 9
            KKYLLLL+
Sbjct: 3046 KKYLLLLI 3053
>XP_005261184
          Length = 3258

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    KKYLLLLL 9
            KKYLLLL+
Sbjct: 3164 KKYLLLLI 3171
>XP_005261183
          Length = 3268

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    KKYLLLLL 9
            KKYLLLL+
Sbjct: 3085 KKYLLLLI 3092
>XP_005261182
          Length = 3346

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    KKYLLLLL 9
            KKYLLLL+
Sbjct: 3163 KKYLLLLI 3170
>XP_005261181
          Length = 3347

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    KKYLLLLL 9
            KKYLLLL+
Sbjct: 3164 KKYLLLLI 3171
>NP_004813
          Length = 604

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LKKYLLL 7
           LKKYLLL
Sbjct: 552 LKKYLLL 558
>XP_006721658
          Length = 604

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LKKYLLL 7
           LKKYLLL
Sbjct: 552 LKKYLLL 558
>XP_005268711
          Length = 288

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   LKKYLLLL 8
           LK+YLLLL
Sbjct: 280 LKEYLLLL 287
>NP_057200
          Length = 426

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LKKYLLL 7
           LKKYLLL
Sbjct: 413 LKKYLLL 419
>NP_077000
          Length = 288

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   LKKYLLLL 8
           LK+YLLLL
Sbjct: 280 LKEYLLLL 287
>NP_570843
          Length = 581

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LKKYLLLLL 9
          LK YLLLL+
Sbjct: 3  LKHYLLLLV 11
>NP_001128529
          Length = 587

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LKKYLLLLL 9
          LK YLLLL+
Sbjct: 9  LKHYLLLLV 17
>NP_001277026
          Length = 142

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LKKYLLLLL 9
          L+ YLLLLL
Sbjct: 49 LQAYLLLLL 57
>NP_001139808
          Length = 223

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           L+ YLLLLL
Sbjct: 130 LQAYLLLLL 138
>NP_079133
          Length = 1844

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LKKYLLLLL 9
           LKKY  LLL
Sbjct: 960 LKKYFPLLL 968
>NP_861420
          Length = 292

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LKKYLLLLL 9
          +KKYLL +L
Sbjct: 4  MKKYLLPIL 12
>NP_005516
          Length = 292

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LKKYLLLLL 9
          +KKYLL +L
Sbjct: 4  MKKYLLPIL 12
>NP_001193670
          Length = 292

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LKKYLLLLL 9
          +KKYLL +L
Sbjct: 4  MKKYLLPIL 12
>NP_001241872
          Length = 1796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLLLL
Sbjct: 121 VKKLLLLLL 129
>NP_001129069
          Length = 1870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLLLL
Sbjct: 121 VKKLLLLLL 129
>NP_060554
          Length = 1843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLLLL
Sbjct: 121 VKKLLLLLL 129
>NP_056526
          Length = 1560

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LKKYLLLLL 9
            L KY LLLL
Sbjct: 1152 LNKYRLLLL 1160
>XP_006723243
          Length = 1200

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LKKYLLLLL 9
           L KY LLLL
Sbjct: 792 LNKYRLLLL 800
>XP_005258890
          Length = 1560

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LKKYLLLLL 9
            L KY LLLL
Sbjct: 1152 LNKYRLLLL 1160
>XP_005264484
          Length = 955

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLLLL
Sbjct: 121 VKKLLLLLL 129
>XP_005264483
          Length = 1311

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLLLL
Sbjct: 121 VKKLLLLLL 129
>XP_005264480
          Length = 1842

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLLLL
Sbjct: 121 VKKLLLLLL 129
>XP_005264478
          Length = 1844

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLLLL
Sbjct: 121 VKKLLLLLL 129
>XP_005264475
          Length = 2027

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLLLL
Sbjct: 121 VKKLLLLLL 129
>NP_085135
          Length = 2248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KKYLLLLL 9
           ++YLLLLL
Sbjct: 280 QQYLLLLL 287
>NP_001265524
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLLLL
Sbjct: 174 VKKALLLLL 182
>NP_877577
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLLLL
Sbjct: 174 VKKALLLLL 182
>NP_005907
          Length = 719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLLLL
Sbjct: 350 VKKALLLLL 358
>NP_112170
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KKYLLL 7
           KKYLLL
Sbjct: 270 KKYLLL 275
>XP_006726516
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KKYLLL 7
           KKYLLL
Sbjct: 270 KKYLLL 275
>XP_005258413
          Length = 2249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KKYLLLLL 9
           ++YLLLLL
Sbjct: 281 QQYLLLLL 288
>XP_005250405
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLLLL
Sbjct: 243 VKKALLLLL 251
>XP_006714534
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LKKYLL 6
          LKKYLL
Sbjct: 87 LKKYLL 92
>NP_001004488
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KKYLLL 7
           KKYLLL
Sbjct: 270 KKYLLL 275
>NP_787117
          Length = 294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKKYLL 6
           LKKYLL
Sbjct: 160 LKKYLL 165
>NP_001005328
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KKYLLL 7
           KKYLLL
Sbjct: 270 KKYLLL 275
>NP_005090
          Length = 837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           LK+YLL ++
Sbjct: 238 LKRYLLTVM 246
>NP_001073883
          Length = 2028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLL+L
Sbjct: 120 IKKVLLLVL 128
>NP_001982
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LKKYLLL 7
           LKK+LLL
Sbjct: 611 LKKHLLL 617
>XP_005257203
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LKKYLLL 7
           LKK+LLL
Sbjct: 571 LKKHLLL 577
>XP_005257202
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LKKYLLL 7
           LKK+LLL
Sbjct: 577 LKKHLLL 583
>XP_005257201
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LKKYLLL 7
           LKK+LLL
Sbjct: 617 LKKHLLL 623
>XP_005267748
          Length = 1535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           +KK LLL+L
Sbjct: 120 IKKVLLLVL 128
>XP_006711698
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKKYLLLLL 9
           LK+YLL ++
Sbjct: 238 LKRYLLTVM 246
>NP_001180264
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1 LKKYLLLL 8
         +K+Y+LLL
Sbjct: 1 MKEYVLLL 8
>NP_543140
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 LKKYLLLLL 9
         + +Y+LLLL
Sbjct: 1 MARYMLLLL 9
>NP_060150
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1 LKKYLLLL 8
         +K+Y+LLL
Sbjct: 1 MKEYVLLL 8
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.166    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 537,526
Number of extensions: 885
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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