Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           20     509
NP_001185763                                                           20     509
NP_055459                                                              20     509
XP_006726410                                                           20     509
XP_006711719                                                           20     509
XP_006711718                                                           20     509
XP_006711717                                                           20     509
XP_006711716                                                           20     509
XP_006711715                                                           20     509
XP_006711714                                                           20     509
XP_006711713                                                           20     509
XP_006711712                                                           20     509
XP_006711711                                                           20     509
XP_006711710                                                           20     509
XP_006711709                                                           20     509
XP_005277503                                                           20     509
XP_005273038                                                           20     509
XP_006711708                                                           20     509
XP_005277500                                                           20     509
XP_006711707                                                           20     509
XP_005277499                                                           20     509
XP_006711706                                                           20     509
XP_006711705                                                           20     509
XP_006711164                                                           20     509
XP_006710143                                                           20     509
XP_006710142                                                           20     509
XP_006710141                                                           20     509
NP_689901                                                              18    1482
XP_006715418                                                           18    1482
XP_006715417                                                           18    1482
NP_003239                                                              17    4312
NP_001609                                                              16    5631
NP_001229695                                                           16    5631
NP_004737                                                              16    5631
NP_001003809                                                           16    5631
NP_001229693                                                           16    5631
NP_001229690                                                           16    5631
NP_001229692                                                           16    5631
NP_001229691                                                           16    5631
NP_001229694                                                           16    5631
XP_005258233                                                           16    5631
XP_005258232                                                           16    5631
XP_005258231                                                           16    5631
XP_006722430                                                           16    5631
XP_005258230                                                           16    5631
XP_005258229                                                           16    5631
XP_005258228                                                           16    5631
NP_619639                                                              16    7355
NP_733842                                                              16    7355
NP_001171536                                                           16    7355
NP_000379                                                              16    7355
NP_004223                                                              16    7355
XP_006722640                                                           16    7355
XP_005266840                                                           16    7355
XP_005247894                                                           16    7355
XP_006713853                                                           16    7355
XP_005247893                                                           16    7355
XP_006713852                                                           16    7355
NP_000085                                                              15    9605
NP_008853                                                              15    9605
NP_001075145                                                           15    9605
NP_001075146                                                           15    9605
NP_722580                                                              15    9605
NP_001239537                                                           15    9605
NP_009043                                                              15    9605
NP_001239536                                                           15    9605
XP_006726574                                                           15    9605
XP_006712742                                                           15    9605
XP_006711564                                                           15    9605
XP_006711563                                                           15    9605
XP_006711562                                                           15    9605
XP_006711561                                                           15    9605
NP_775779                                                              15    9605
>NP_001185761
          Length = 2240

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1437 QARELSYLR 1445
>NP_001185763
          Length = 2362

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1481 QARELSYLR 1489
>NP_055459
          Length = 2346

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1481 QARELSYLR 1489
>XP_006726410
          Length = 2087

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1284 QARELSYLR 1292
>XP_006711719
          Length = 2302

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1437 QARELSYLR 1445
>XP_006711718
          Length = 1436

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           Q RELSYLR
Sbjct: 488 QARELSYLR 496
>XP_006711717
          Length = 2385

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1437 QARELSYLR 1445
>XP_006711716
          Length = 2411

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1546 QARELSYLR 1554
>XP_006711715
          Length = 2428

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1480 QARELSYLR 1488
>XP_006711714
          Length = 2429

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1481 QARELSYLR 1489
>XP_006711713
          Length = 2432

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1484 QARELSYLR 1492
>XP_006711712
          Length = 2473

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1644 QARELSYLR 1652
>XP_006711711
          Length = 2482

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1534 QARELSYLR 1542
>XP_006711710
          Length = 2494

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1546 QARELSYLR 1554
>XP_006711709
          Length = 2495

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1547 QARELSYLR 1555
>XP_005277503
          Length = 2498

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1644 QARELSYLR 1652
>XP_005273038
          Length = 2509

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1644 QARELSYLR 1652
>XP_006711708
          Length = 2512

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1644 QARELSYLR 1652
>XP_005277500
          Length = 2525

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1644 QARELSYLR 1652
>XP_006711707
          Length = 2553

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1644 QARELSYLR 1652
>XP_005277499
          Length = 2561

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1644 QARELSYLR 1652
>XP_006711706
          Length = 2591

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1643 QARELSYLR 1651
>XP_006711705
          Length = 2592

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1644 QARELSYLR 1652
>XP_006711164
          Length = 2087

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QVRELSYLR 9
            Q RELSYLR
Sbjct: 1284 QARELSYLR 1292
>XP_006710143
          Length = 562

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           Q RELSYLR
Sbjct: 323 QARELSYLR 331
>XP_006710142
          Length = 671

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           Q RELSYLR
Sbjct: 432 QARELSYLR 440
>XP_006710141
          Length = 672

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           Q RELSYLR
Sbjct: 433 QARELSYLR 441
>NP_689901
          Length = 349

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   QVRELSYL 8
           Q+RELSYL
Sbjct: 171 QLRELSYL 178
>XP_006715418
          Length = 312

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   QVRELSYL 8
           Q+RELSYL
Sbjct: 171 QLRELSYL 178
>XP_006715417
          Length = 352

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   QVRELSYL 8
           Q+RELSYL
Sbjct: 171 QLRELSYL 178
>NP_003239
          Length = 961

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           QV+E S+LR
Sbjct: 244 QVKETSFLR 252
>NP_001609
          Length = 1014

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           + RE+SYL+
Sbjct: 338 EFREISYLK 346
>NP_001229695
          Length = 685

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 99  QIRSHSYLR 107
>NP_004737
          Length = 977

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 401 QIRSHSYLR 409
>NP_001003809
          Length = 675

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 99  QIRSHSYLR 107
>NP_001229693
          Length = 683

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 107 QIRSHSYLR 115
>NP_001229690
          Length = 929

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 401 QIRSHSYLR 409
>NP_001229692
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 113 QIRSHSYLR 121
>NP_001229691
          Length = 661

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 113 QIRSHSYLR 121
>NP_001229694
          Length = 627

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 99  QIRSHSYLR 107
>XP_005258233
          Length = 672

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  QVRELSYLR 9
          Q+R  SYLR
Sbjct: 86 QIRSHSYLR 94
>XP_005258232
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 107 QIRSHSYLR 115
>XP_005258231
          Length = 695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 109 QIRSHSYLR 117
>XP_006722430
          Length = 731

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 145 QIRSHSYLR 153
>XP_005258230
          Length = 737

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 151 QIRSHSYLR 159
>XP_005258229
          Length = 987

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 401 QIRSHSYLR 409
>XP_005258228
          Length = 987

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRELSYLR 9
           Q+R  SYLR
Sbjct: 401 QIRSHSYLR 409
>NP_619639
          Length = 4074

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    QVRELSYL 8
            Q+R+L+YL
Sbjct: 2695 QLRQLTYL 2702
>NP_733842
          Length = 3396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    QVRELSYL 8
            Q+R+L+YL
Sbjct: 2695 QLRQLTYL 2702
>NP_001171536
          Length = 1088

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RELSYL 8
           RELSYL
Sbjct: 658 RELSYL 663
>NP_000379
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RELSYL 8
           RELSYL
Sbjct: 648 RELSYL 653
>NP_004223
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   QVRELSYL 8
           QVR L YL
Sbjct: 496 QVRSLQYL 503
>XP_006722640
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   QVRELSYL 8
           QVR L YL
Sbjct: 496 QVRSLQYL 503
>XP_005266840
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   QVRELSYL 8
           QVR L YL
Sbjct: 496 QVRSLQYL 503
>XP_005247894
          Length = 917

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RELSYL 8
           RELSYL
Sbjct: 487 RELSYL 492
>XP_006713853
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RELSYL 8
           RELSYL
Sbjct: 648 RELSYL 653
>XP_005247893
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RELSYL 8
           RELSYL
Sbjct: 648 RELSYL 653
>XP_006713852
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RELSYL 8
           RELSYL
Sbjct: 648 RELSYL 653
>NP_000085
          Length = 2944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VRELSY 7
           +RELSY
Sbjct: 107 IRELSY 112
>NP_008853
          Length = 2000

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RELSYLR 9
            +EL+YLR
Sbjct: 1059 KELNYLR 1065
>NP_001075145
          Length = 1951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RELSYLR 9
            +EL+YLR
Sbjct: 1010 KELNYLR 1016
>NP_001075146
          Length = 1951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RELSYLR 9
            +EL+YLR
Sbjct: 1010 KELNYLR 1016
>NP_722580
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRELSYLR 9
           V E+SY+R
Sbjct: 432 VTEISYMR 439
>NP_001239537
          Length = 836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           QV+E+S +R
Sbjct: 132 QVKEMSLIR 140
>NP_009043
          Length = 956

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           QV+E+S +R
Sbjct: 252 QVKEMSLIR 260
>NP_001239536
          Length = 947

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           QV+E+S +R
Sbjct: 243 QVKEMSLIR 251
>XP_006726574
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RELSYLR 9
           RE+ YLR
Sbjct: 171 REIQYLR 177
>XP_006712742
          Length = 2000

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RELSYLR 9
            +EL+YLR
Sbjct: 1059 KELNYLR 1065
>XP_006711564
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           QV+E+S +R
Sbjct: 309 QVKEMSLIR 317
>XP_006711563
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           QV+E+S +R
Sbjct: 214 QVKEMSLIR 222
>XP_006711562
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           QV+E+S +R
Sbjct: 214 QVKEMSLIR 222
>XP_006711561
          Length = 1013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QVRELSYLR 9
           QV+E+S +R
Sbjct: 309 QVKEMSLIR 317
>NP_775779
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QVRELSYL 8
          Q+R+L YL
Sbjct: 37 QLRQLKYL 44
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.139    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 515,893
Number of extensions: 732
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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