Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              19     665
XP_005248577                                                           19     665
XP_005248576                                                           19     665
NP_000930                                                              16    5631
NP_001030333                                                           16    5631
NP_065826                                                              16    5631
NP_001253977                                                           16    5631
NP_055029                                                              16    7355
NP_001185863                                                           16    7355
NP_258261                                                              16    7355
XP_005249527                                                           16    7355
XP_006715303                                                           16    7355
NP_001098985                                                           15    9605
NP_005836                                                              15    9605
NP_004906                                                              15    9605
NP_997511                                                              15    9605
NP_058198                                                              15    9605
NP_997512                                                              15    9605
NP_997510                                                              15    9605
NP_997057                                                              15    9605
NP_055426                                                              15    9605
NP_004858                                                              15    9605
NP_056046                                                              15    9605
NP_008985                                                              15    9605
NP_001171516                                                           15    9605
NP_001171515                                                           15    9605
NP_079533                                                              15    9605
XP_005254082                                                           15    9605
XP_006719977                                                           15    9605
XP_006715467                                                           15    9605
XP_005271926                                                           15    9605
XP_006714589                                                           15    9605
XP_005271925                                                           15    9605
NP_001135977                                                           15    9605
NP_071452                                                              15    9605
>NP_005912
          Length = 1512

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TGQRLRIA 8
            TGQRLRIA
Sbjct: 1380 TGQRLRIA 1387
>XP_005248577
          Length = 1349

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TGQRLRIA 8
            TGQRLRIA
Sbjct: 1217 TGQRLRIA 1224
>XP_005248576
          Length = 1375

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TGQRLRIA 8
            TGQRLRIA
Sbjct: 1243 TGQRLRIA 1250
>NP_000930
          Length = 267

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TGQRLR 6
           TGQRLR
Sbjct: 181 TGQRLR 186
>NP_001030333
          Length = 267

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TGQRLR 6
           TGQRLR
Sbjct: 181 TGQRLR 186
>NP_065826
          Length = 1013

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TGQRLRIAV 9
          TG R R+AV
Sbjct: 64 TGSRWRVAV 72
>NP_001253977
          Length = 926

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TGQRLRIAV 9
          TG R R+AV
Sbjct: 64 TGSRWRVAV 72
>NP_055029
          Length = 288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GQRLRIA 8
           GQRLR++
Sbjct: 154 GQRLRVS 160
>NP_001185863
          Length = 1492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           GQR RIA+
Sbjct: 729 GQRARIAL 736
>NP_258261
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           GQR RIA+
Sbjct: 701 GQRARIAL 708
>XP_005249527
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           GQR RIA+
Sbjct: 729 GQRARIAL 736
>XP_006715303
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           GQR RIA+
Sbjct: 729 GQRARIAL 736
>NP_001098985
          Length = 859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           G RLR+A+
Sbjct: 163 GMRLRVAM 170
>NP_005836
          Length = 1325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           G RLR+A+
Sbjct: 163 GMRLRVAM 170
>NP_004906
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           GQR R+A+
Sbjct: 220 GQRKRLAI 227
>NP_997511
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           GQR R+A+
Sbjct: 198 GQRKRLAI 205
>NP_058198
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           GQR R+A+
Sbjct: 220 GQRKRLAI 227
>NP_997512
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           GQR R+A+
Sbjct: 217 GQRKRLAI 224
>NP_997510
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           GQR R+A+
Sbjct: 222 GQRKRLAI 229
>NP_997057
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           GQR R+A+
Sbjct: 231 GQRKRLAI 238
>NP_055426
          Length = 5596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TGQRLRI 7
           TG RLR+
Sbjct: 694 TGHRLRV 700
>NP_004858
          Length = 263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TGQRLRIA 8
          TG+ LR+A
Sbjct: 35 TGKELRVA 42
>NP_056046
          Length = 1436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TGQRLRIA 8
           TG +LR+A
Sbjct: 340 TGHKLRLA 347
>NP_008985
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TGQRLRIA 8
           TGQRL+ A
Sbjct: 263 TGQRLKEA 270
>NP_001171516
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QRLRIAV 9
           QR+RIA+
Sbjct: 256 QRIRIAI 262
>NP_001171515
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QRLRIAV 9
           QR+RIA+
Sbjct: 290 QRIRIAI 296
>NP_079533
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QRLRIAV 9
           QR+RIA+
Sbjct: 332 QRIRIAI 338
>XP_005254082
          Length = 1282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           G RLR+A+
Sbjct: 120 GMRLRVAM 127
>XP_006719977
          Length = 1295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           G RLR+A+
Sbjct: 163 GMRLRVAM 170
>XP_006715467
          Length = 5550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TGQRLRI 7
           TG RLR+
Sbjct: 694 TGHRLRV 700
>XP_005271926
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TGQRLRIA 8
           TGQRL+ A
Sbjct: 263 TGQRLKEA 270
>XP_006714589
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TGQRLRIA 8
           TGQRL+ A
Sbjct: 263 TGQRLKEA 270
>XP_005271925
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TGQRLRIA 8
           TGQRL+ A
Sbjct: 263 TGQRLKEA 270
>NP_001135977
          Length = 646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           GQR R+A+
Sbjct: 204 GQRKRLAI 211
>NP_071452
          Length = 646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GQRLRIAV 9
           GQR R+A+
Sbjct: 204 GQRKRLAI 211
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.143    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 491,595
Number of extensions: 738
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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