Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              20     390
XP_005248577                                                           20     390
XP_005248576                                                           20     390
NP_940847                                                              17    4312
NP_001182762                                                           17    4312
XP_006723079                                                           17    4312
XP_006723078                                                           17    4312
NP_689607                                                              16    5631
XP_005247177                                                           16    5631
XP_005247176                                                           16    5631
XP_006713561                                                           16    5631
NP_803875                                                              16    5631
NP_055474                                                              16    7355
NP_001124331                                                           16    7355
NP_001124330                                                           16    7355
NP_001177143                                                           16    7355
NP_001138328                                                           16    7355
NP_001138329                                                           16    7355
NP_060643                                                              16    7355
XP_006720850                                                           16    7355
XP_006720849                                                           16    7355
XP_005254861                                                           16    7355
XP_006720848                                                           16    7355
XP_005254860                                                           16    7355
XP_006720847                                                           16    7355
XP_006720846                                                           16    7355
XP_005254859                                                           16    7355
XP_006720845                                                           16    7355
XP_005254858                                                           16    7355
XP_006719048                                                           16    7355
XP_005253761                                                           16    7355
XP_006710293                                                           16    7355
NP_056224                                                              15    9605
NP_001229761                                                           15    9605
NP_115765                                                              15    9605
NP_071353                                                              15    9605
XP_006726449                                                           15    9605
XP_005257627                                                           15    9605
XP_005253225                                                           15    9605
XP_006718409                                                           15    9605
XP_005253224                                                           15    9605
XP_005253223                                                           15    9605
XP_006712222                                                           15    9605
>NP_005912
          Length = 1512

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IIIQQDTP 9
            IIIQQDTP
Sbjct: 1217 IIIQQDTP 1224
>XP_005248577
          Length = 1349

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IIIQQDTP 9
            IIIQQDTP
Sbjct: 1054 IIIQQDTP 1061
>XP_005248576
          Length = 1375

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IIIQQDTP 9
            IIIQQDTP
Sbjct: 1080 IIIQQDTP 1087
>NP_940847
          Length = 452

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  IQQDTP 9
          +QQDTP
Sbjct: 44 VQQDTP 49
>NP_001182762
          Length = 566

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IQQDTP 9
           +QQDTP
Sbjct: 158 VQQDTP 163
>XP_006723079
          Length = 472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  IQQDTP 9
          +QQDTP
Sbjct: 44 VQQDTP 49
>XP_006723078
          Length = 586

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IQQDTP 9
           +QQDTP
Sbjct: 158 VQQDTP 163
>NP_689607
          Length = 663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TIIIQQDTP 9
           T I+Q+D P
Sbjct: 467 TCIVQEDMP 475
>XP_005247177
          Length = 512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TIIIQQDTP 9
           T I+Q+D P
Sbjct: 467 TCIVQEDMP 475
>XP_005247176
          Length = 517

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TIIIQQDTP 9
           T I+Q+D P
Sbjct: 321 TCIVQEDMP 329
>XP_006713561
          Length = 616

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TIIIQQDTP 9
           T I+Q+D P
Sbjct: 420 TCIVQEDMP 428
>NP_803875
          Length = 4243

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TIIIQQDTP 9
            TI++ Q TP
Sbjct: 2205 TILLDQSTP 2213
>NP_055474
          Length = 1408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>NP_001124331
          Length = 1408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>NP_001124330
          Length = 1433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>NP_001177143
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>NP_001138328
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           IIQ DTP
Sbjct: 778 IIQLDTP 784
>NP_001138329
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           IIQ DTP
Sbjct: 746 IIQLDTP 752
>NP_060643
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           IIQ DTP
Sbjct: 778 IIQLDTP 784
>XP_006720850
          Length = 1421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>XP_006720849
          Length = 1366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>XP_005254861
          Length = 1408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>XP_006720848
          Length = 1427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>XP_005254860
          Length = 1429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>XP_006720847
          Length = 1461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>XP_006720846
          Length = 1469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>XP_005254859
          Length = 1469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>XP_006720845
          Length = 1469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>XP_005254858
          Length = 1469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 638 ILQQDAP 644
>XP_006719048
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           IIQ DTP
Sbjct: 764 IIQLDTP 770
>XP_005253761
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           IIQ DTP
Sbjct: 778 IIQLDTP 784
>XP_006710293
          Length = 807

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IIQQDTP 9
           I+QQD P
Sbjct: 296 ILQQDAP 302
>NP_056224
          Length = 3123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    IIQQDTP 9
            ++QQ TP
Sbjct: 3014 VVQQQTP 3020
>NP_001229761
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IIQQDTP 9
           +I+Q+TP
Sbjct: 298 VIEQETP 304
>NP_115765
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IIQQDTP 9
           +I+Q+TP
Sbjct: 326 VIEQETP 332
>NP_071353
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TIIIQQDTP 9
           T+I+  +TP
Sbjct: 886 TLIVNMETP 894
>XP_006726449
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IIQQDTP 9
           +IQ++TP
Sbjct: 423 VIQEETP 429
>XP_005257627
          Length = 1013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TIIIQQDTP 9
           T+I+  +TP
Sbjct: 718 TLIVNMETP 726
>XP_005253225
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IIQQDTP 9
           +I+Q+TP
Sbjct: 340 VIEQETP 346
>XP_006718409
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IIQQDTP 9
           +I+Q+TP
Sbjct: 351 VIEQETP 357
>XP_005253224
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IIQQDTP 9
           +I+Q+TP
Sbjct: 354 VIEQETP 360
>XP_005253223
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IIQQDTP 9
           +I+Q+TP
Sbjct: 365 VIEQETP 371
>XP_006712222
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IIQQDTP 9
           +IQ++TP
Sbjct: 423 VIQEETP 429
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.137    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 583,580
Number of extensions: 940
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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