Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001156685                                                           22     134
XP_006713934                                                           22     134
XP_006713933                                                           22     134
XP_006713932                                                           22     134
XP_006713931                                                           22     134
NP_000133                                                              20     299
XP_006713936                                                           20     299
XP_006713935                                                           20     299
NP_075254                                                              20     390
NP_000388                                                              17    4312
NP_039249                                                              17    4312
NP_008983                                                              17    4312
NP_001258744                                                           17    4312
NP_775922                                                              17    4312
NP_075252                                                              16    5631
NP_998812                                                              16    5631
NP_002002                                                              16    5631
XP_005265895                                                           16    5631
XP_005265894                                                           16    5631
NP_001167535                                                           16    7355
NP_001167534                                                           16    7355
NP_001167536                                                           16    7355
NP_001167537                                                           16    7355
NP_001138390                                                           16    7355
NP_001138387                                                           16    7355
NP_000132                                                              16    7355
NP_001138388                                                           16    7355
NP_056934                                                              16    7355
NP_075598                                                              16    7355
NP_075594                                                              16    7355
NP_075593                                                              16    7355
NP_075418                                                              16    7355
NP_001167538                                                           16    7355
XP_006717776                                                           16    7355
XP_006717772                                                           16    7355
XP_006716377                                                           16    7355
XP_006716376                                                           16    7355
XP_006716375                                                           16    7355
XP_006716374                                                           16    7355
XP_006716373                                                           16    7355
XP_006716372                                                           16    7355
XP_006716371                                                           16    7355
XP_006716370                                                           16    7355
XP_006716369                                                           16    7355
XP_006716368                                                           16    7355
XP_006716367                                                           16    7355
XP_006716366                                                           16    7355
NP_001138389                                                           15    9605
NP_075259                                                              15    9605
NP_001138391                                                           15    9605
NP_001138385                                                           15    9605
NP_078858                                                              15    9605
NP_001278232                                                           15    9605
NP_001278214                                                           15    9605
NP_056533                                                              15    9605
NP_055798                                                              15    9605
NP_001165422                                                           15    9605
NP_003137                                                              15    9605
NP_001001317                                                           15    9605
NP_055061                                                              15    9605
NP_001008271                                                           15    9605
XP_006724446                                                           15    9605
XP_005274251                                                           15    9605
XP_006717775                                                           15    9605
XP_006717774                                                           15    9605
XP_006717773                                                           15    9605
XP_006717771                                                           15    9605
XP_005250004                                                           15    9605
XP_005250003                                                           15    9605
XP_006714830                                                           15    9605
XP_006714829                                                           15    9605
XP_006714828                                                           15    9605
>NP_001156685
          Length = 808

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TPYITVLKS 9
           TPY+TVLKS
Sbjct: 303 TPYVTVLKS 311
>XP_006713934
          Length = 809

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TPYITVLKS 9
           TPY+TVLKS
Sbjct: 303 TPYVTVLKS 311
>XP_006713933
          Length = 810

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TPYITVLKS 9
           TPY+TVLKS
Sbjct: 303 TPYVTVLKS 311
>XP_006713932
          Length = 810

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TPYITVLKS 9
           TPY+TVLKS
Sbjct: 303 TPYVTVLKS 311
>XP_006713931
          Length = 811

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TPYITVLKS 9
           TPY+TVLKS
Sbjct: 303 TPYVTVLKS 311
>NP_000133
          Length = 806

 Score = 20.4 bits (41), Expect =   299
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   TPYITVLKS 9
           TPY+TVLK+
Sbjct: 303 TPYVTVLKT 311
>XP_006713936
          Length = 807

 Score = 20.4 bits (41), Expect =   299
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   TPYITVLKS 9
           TPY+TVLK+
Sbjct: 303 TPYVTVLKT 311
>XP_006713935
          Length = 807

 Score = 20.4 bits (41), Expect =   299
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   TPYITVLKS 9
           TPY+TVLK+
Sbjct: 303 TPYVTVLKT 311
>NP_075254
          Length = 694

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   TPYITVLK 8
           TPY+TVLK
Sbjct: 303 TPYVTVLK 310
>NP_000388
          Length = 570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TPYITVLKS 9
           TP+ ++LKS
Sbjct: 414 TPFASILKS 422
>NP_039249
          Length = 515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TPYITVLKS 9
           TP+ ++LKS
Sbjct: 408 TPFASILKS 416
>NP_008983
          Length = 564

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TPYITVLKS 9
           TP+ ++LKS
Sbjct: 408 TPFASILKS 416
>NP_001258744
          Length = 527

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TPYITVLKS 9
           TP+ ++LKS
Sbjct: 371 TPFASILKS 379
>NP_775922
          Length = 6996

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    PYITVL 7
            PYITVL
Sbjct: 5197 PYITVL 5202
>NP_075252
          Length = 762

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ VLK+
Sbjct: 300 PYVQVLKT 307
>NP_998812
          Length = 802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ VLK+
Sbjct: 300 PYVQVLKT 307
>NP_002002
          Length = 802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ VLK+
Sbjct: 300 PYVQVLKT 307
>XP_005265895
          Length = 802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ VLK+
Sbjct: 300 PYVQVLKT 307
>XP_005265894
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ VLK+
Sbjct: 332 PYVQVLKT 339
>NP_001167535
          Length = 812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 298 PYVQILKT 305
>NP_001167534
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 306 PYVQILKT 313
>NP_001167536
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 304 PYVQILKT 311
>NP_001167537
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 217 PYVQILKT 224
>NP_001138390
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ VLK+
Sbjct: 192 PYLKVLKA 199
>NP_001138387
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ VLK+
Sbjct: 218 PYLKVLKA 225
>NP_000132
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ VLK+
Sbjct: 307 PYLKVLKA 314
>NP_001138388
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ VLK+
Sbjct: 192 PYLKVLKA 199
>NP_056934
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 304 PYVQILKT 311
>NP_075598
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 306 PYVQILKT 313
>NP_075594
          Length = 731

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 215 PYVQILKT 222
>NP_075593
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 217 PYVQILKT 224
>NP_075418
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ VLK+
Sbjct: 218 PYLKVLKA 225
>NP_001167538
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 337 PYVQILKT 344
>XP_006717776
          Length = 806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ VLK+
Sbjct: 326 PYLKVLKA 333
>XP_006717772
          Length = 838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ VLK+
Sbjct: 326 PYLKVLKA 333
>XP_006716377
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 215 PYVQILKT 222
>XP_006716376
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 215 PYVQILKT 222
>XP_006716375
          Length = 743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 217 PYVQILKT 224
>XP_006716374
          Length = 743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 217 PYVQILKT 224
>XP_006716373
          Length = 743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 217 PYVQILKT 224
>XP_006716372
          Length = 824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 298 PYVQILKT 305
>XP_006716371
          Length = 830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 306 PYVQILKT 313
>XP_006716370
          Length = 830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 304 PYVQILKT 311
>XP_006716369
          Length = 830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 304 PYVQILKT 311
>XP_006716368
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 306 PYVQILKT 313
>XP_006716367
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 306 PYVQILKT 313
>XP_006716366
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PYITVLKS 9
           PY+ +LK+
Sbjct: 306 PYVQILKT 313
>NP_001138389
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PYITVLK 8
           PY+ VLK
Sbjct: 307 PYLKVLK 313
>NP_075259
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PYITVLK 8
           PY+ VLK
Sbjct: 307 PYLKVLK 313
>NP_001138391
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PYITVLK 8
           PY+ VLK
Sbjct: 218 PYLKVLK 224
>NP_001138385
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PYITVLK 8
           PY+ VLK
Sbjct: 307 PYLKVLK 313
>NP_078858
          Length = 4981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    YITVLK 8
            YIT+LK
Sbjct: 1634 YITILK 1639
>NP_001278232
          Length = 4983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    YITVLK 8
            YIT+LK
Sbjct: 1634 YITILK 1639
>NP_001278214
          Length = 4982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    YITVLK 8
            YIT+LK
Sbjct: 1634 YITILK 1639
>NP_056533
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TPYITVLKS 9
           TP+  +LKS
Sbjct: 412 TPFAALLKS 420
>NP_055798
          Length = 1292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    PYITVLKS 9
            PY T+L S
Sbjct: 1199 PYATILAS 1206
>NP_001165422
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  PYITVLKS 9
          PY+  LKS
Sbjct: 28 PYLVYLKS 35
>NP_003137
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PYITVLK 8
           PY TVL+
Sbjct: 235 PYTTVLR 241
>NP_001001317
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  PYITVLKS 9
          PY+  LKS
Sbjct: 29 PYLVYLKS 36
>NP_055061
          Length = 3014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TPYITVL 7
           T YITVL
Sbjct: 336 TTYITVL 342
>NP_001008271
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  PYITVLKS 9
          PY+  LKS
Sbjct: 28 PYLVYLKS 35
>XP_006724446
          Length = 3019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TPYITVL 7
           T YITVL
Sbjct: 336 TTYITVL 342
>XP_005274251
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PYITVLK 8
           PY TVL+
Sbjct: 235 PYTTVLR 241
>XP_006717775
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PYITVLK 8
           PY+ VLK
Sbjct: 211 PYLKVLK 217
>XP_006717774
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PYITVLK 8
           PY+ VLK
Sbjct: 237 PYLKVLK 243
>XP_006717773
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PYITVLK 8
           PY+ VLK
Sbjct: 326 PYLKVLK 332
>XP_006717771
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PYITVLK 8
           PY+ VLK
Sbjct: 326 PYLKVLK 332
>XP_005250004
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  PYITVLKS 9
          PY+  LKS
Sbjct: 28 PYLVYLKS 35
>XP_005250003
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  PYITVLKS 9
          PY+  LKS
Sbjct: 28 PYLVYLKS 35
>XP_006714830
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PYITVLKS 9
           PY T+L S
Sbjct: 914 PYATILAS 921
>XP_006714829
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    PYITVLKS 9
            PY T+L S
Sbjct: 1000 PYATILAS 1007
>XP_006714828
          Length = 1126

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    PYITVLKS 9
            PY T+L S
Sbjct: 1033 PYATILAS 1040
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.131    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 491,965
Number of extensions: 744
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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