Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              19     869
NP_000182                                                              17    3301
NP_001159531                                                           17    3301
NP_694539                                                              16    7355
NP_001180404                                                           16    7355
NP_004678                                                              16    7355
NP_001129101                                                           16    7355
XP_006722231                                                           16    7355
XP_005257843                                                           16    7355
XP_005257842                                                           16    7355
XP_005257841                                                           16    7355
NP_057411                                                              15    9605
XP_005261690                                                           15    9605
XP_005260020                                                           15    9605
NP_060152                                                              15    9605

>NP_004351
          Length = 882

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TYNAAIANT 9
           TYNAAIA T
Sbjct: 295 TYNAAIAYT 303



>NP_000182
          Length = 325

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TYNAAIANT 9
           TY  A+ANT
Sbjct: 237 TYGQALANT 245



>NP_001159531
          Length = 254

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TYNAAIANT 9
           TY  A+ANT
Sbjct: 166 TYGQALANT 174



>NP_694539
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NAAIANT 9
           NAA++NT
Sbjct: 619 NAAVSNT 625



>NP_001180404
          Length = 738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NAAIANT 9
           NAA++NT
Sbjct: 588 NAAVSNT 594



>NP_004678
          Length = 1195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYNAAIAN 8
           +Y AA+AN
Sbjct: 313 SYTAAVAN 320



>NP_001129101
          Length = 780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NAAIANT 9
           NAA++NT
Sbjct: 619 NAAVSNT 625



>XP_006722231
          Length = 1195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYNAAIAN 8
           +Y AA+AN
Sbjct: 313 SYTAAVAN 320



>XP_005257843
          Length = 1195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYNAAIAN 8
           +Y AA+AN
Sbjct: 313 SYTAAVAN 320



>XP_005257842
          Length = 1199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYNAAIAN 8
           +Y AA+AN
Sbjct: 317 SYTAAVAN 324



>XP_005257841
          Length = 1209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYNAAIAN 8
           +Y AA+AN
Sbjct: 327 SYTAAVAN 334



>NP_057411
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   NAAIAN 8
           NAAIAN
Sbjct: 274 NAAIAN 279



>XP_005261690
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   NAAIAN 8
           NAAIAN
Sbjct: 206 NAAIAN 211



>XP_005260020
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  TYNAAIAN 8
          TY A +AN
Sbjct: 4  TYTARVAN 11



>NP_060152
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  TYNAAIAN 8
          TY A +AN
Sbjct: 4  TYTARVAN 11



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.110    0.288 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 326,512
Number of extensions: 347
Number of successful extensions: 15
Number of sequences better than 10000.0: 15
Number of HSP's gapped: 15
Number of HSP's successfully gapped: 15
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)