Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              18    1482
NP_689549                                                              18    1935
NP_001438                                                              18    1935
XP_006714824                                                           18    1935
NP_000493                                                              17    4312
NP_057028                                                              17    4312
NP_001139287                                                           17    4312
XP_006722191                                                           17    4312
NP_001009571                                                           16    7355
NP_060424                                                              16    7355
NP_001161412                                                           16    7355
XP_005250765                                                           16    7355
XP_005250764                                                           16    7355
XP_005250763                                                           16    7355
XP_005250762                                                           16    7355
XP_005250761                                                           16    7355
XP_005250760                                                           16    7355
XP_005250759                                                           16    7355
XP_005250758                                                           16    7355
XP_005250757                                                           16    7355
XP_005250756                                                           16    7355
XP_005250755                                                           16    7355
XP_005250754                                                           16    7355
XP_005250753                                                           16    7355
XP_005250752                                                           16    7355
NP_001009894                                                           16    7355
NP_001276090                                                           15    9605
NP_001276089                                                           15    9605
NP_005922                                                              15    9605
NP_005304                                                              15    9605
NP_001186623                                                           15    9605
NP_001186622                                                           15    9605
NP_001186621                                                           15    9605
NP_001073341                                                           15    9605
NP_003579                                                              15    9605
NP_057655                                                              15    9605
NP_003031                                                              15    9605
XP_006726158                                                           15    9605
XP_006726065                                                           15    9605
XP_006724848                                                           15    9605
XP_006724847                                                           15    9605
XP_005262538                                                           15    9605
XP_006716157                                                           15    9605
XP_006713999                                                           15    9605
XP_005246782                                                           15    9605
XP_005246780                                                           15    9605
XP_005246776                                                           15    9605
XP_006712723                                                           15    9605
XP_006712722                                                           15    9605
XP_005246775                                                           15    9605
>NP_005179
          Length = 906

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VLARRTLS 8
           VLARRTLS
Sbjct: 784 VLARRTLS 791
>NP_689549
          Length = 1066

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VLARRTLSH 9
          +LAR+ LSH
Sbjct: 60 ILARKNLSH 68
>NP_001438
          Length = 4349

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    LARRTLSH 9
            LARRTL H
Sbjct: 1008 LARRTLCH 1015
>XP_006714824
          Length = 4349

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    LARRTLSH 9
            LARRTL H
Sbjct: 1008 LARRTLCH 1015
>NP_000493
          Length = 715

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ARRTLSH 9
           ARRTL H
Sbjct: 444 ARRTLGH 450
>NP_057028
          Length = 439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLARRTLSH 9
           ++ARR LSH
Sbjct: 93  LVARRILSH 101
>NP_001139287
          Length = 594

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLARRTLSH 9
           ++ARR LSH
Sbjct: 93  LVARRILSH 101
>XP_006722191
          Length = 715

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ARRTLSH 9
           ARRTL H
Sbjct: 444 ARRTLGH 450
>NP_001009571
          Length = 1255

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 646 ILQRQTLDH 654
>NP_060424
          Length = 1296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 649 ILQRQTLDH 657
>NP_001161412
          Length = 1300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 649 ILQRQTLDH 657
>XP_005250765
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 646 ILQRQTLDH 654
>XP_005250764
          Length = 1258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 649 ILQRQTLDH 657
>XP_005250763
          Length = 1260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 646 ILQRQTLDH 654
>XP_005250762
          Length = 1260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 649 ILQRQTLDH 657
>XP_005250761
          Length = 1265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 649 ILQRQTLDH 657
>XP_005250760
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 649 ILQRQTLDH 657
>XP_005250759
          Length = 1293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 646 ILQRQTLDH 654
>XP_005250758
          Length = 1298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 649 ILQRQTLDH 657
>XP_005250757
          Length = 1300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 646 ILQRQTLDH 654
>XP_005250756
          Length = 1301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 649 ILQRQTLDH 657
>XP_005250755
          Length = 1303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 649 ILQRQTLDH 657
>XP_005250754
          Length = 1305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 646 ILQRQTLDH 654
>XP_005250753
          Length = 1305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 649 ILQRQTLDH 657
>XP_005250752
          Length = 1308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           +L R+TL H
Sbjct: 649 ILQRQTLDH 657
>NP_001009894
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VLARRTLSH 9
          VLA  T+SH
Sbjct: 34 VLATETVSH 42
>NP_001276090
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           RRTL+H
Sbjct: 97  RRTLTH 102
>NP_001276089
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RRTLSH 9
          RRTL+H
Sbjct: 65 RRTLTH 70
>NP_005922
          Length = 383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           RRTL+H
Sbjct: 97  RRTLTH 102
>NP_005304
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLARRTLSH 9
           V +R+T SH
Sbjct: 301 VASRKTFSH 309
>NP_001186623
          Length = 1227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           RRTL+H
Sbjct: 363 RRTLAH 368
>NP_001186622
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           RRTL+H
Sbjct: 368 RRTLAH 373
>NP_001186621
          Length = 1241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           RRTL+H
Sbjct: 377 RRTLAH 382
>NP_001073341
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           R+TLSH
Sbjct: 843 RKTLSH 848
>NP_003579
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           R+TLSH
Sbjct: 861 RKTLSH 866
>NP_057655
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LARRTLSH 9
           +A+R LSH
Sbjct: 187 IAKRQLSH 194
>NP_003031
          Length = 1241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           RRTL+H
Sbjct: 377 RRTLAH 382
>XP_006726158
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RRTLSH 9
          RRTL+H
Sbjct: 65 RRTLTH 70
>XP_006726065
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RRTLSH 9
          RRTL+H
Sbjct: 65 RRTLTH 70
>XP_006724848
          Length = 900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           R+TLSH
Sbjct: 848 RKTLSH 853
>XP_006724847
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           R+TLSH
Sbjct: 850 RKTLSH 855
>XP_005262538
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           R+TLSH
Sbjct: 863 RKTLSH 868
>XP_006716157
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           RRTL+H
Sbjct: 377 RRTLAH 382
>XP_006713999
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ARRTLSH 9
          ARR LSH
Sbjct: 36 ARRGLSH 42

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ARRTLSH 9
           ARR LSH
Sbjct: 209 ARRGLSH 215
>XP_005246782
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           +RTLSH
Sbjct: 690 KRTLSH 695
>XP_005246780
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           +RTLSH
Sbjct: 916 KRTLSH 921
>XP_005246776
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           +RTLSH
Sbjct: 938 KRTLSH 943
>XP_006712723
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           +RTLSH
Sbjct: 938 KRTLSH 943
>XP_006712722
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           +RTLSH
Sbjct: 938 KRTLSH 943
>XP_005246775
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRTLSH 9
           +RTLSH
Sbjct: 938 KRTLSH 943
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.132    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 374,576
Number of extensions: 573
Number of successful extensions: 51
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package