Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TP53 | HHHHTGRLQ | LARGE_INTESTINE | 248 | p.C238fs | c.712_725delTGTAACAGTTCCTG | Frame_Shift_Del | 7 | 0.22 | SW1417 | N | 0 | 0 | 0 | N | ||||||||||||
| TP53 | HHHTGRLQW | LARGE_INTESTINE | 249 | p.C238fs | c.712_725delTGTAACAGTTCCTG | Frame_Shift_Del | 7 | 0.22 | SW1417 | N | 3 | 0 | 0 | N | ||||||||||||
| TP53 | SEWKEICVW | SALIVARY_GLAND | 195 | p.E180fs | c.539_539delA | Frame_Shift_Del | 7 | 0.22 | A253 | N | 6 | 0 | 0 | N | ||||||||||||
| TP53 | SEWKEICVW | LUNG | 195 | p.P191fs | c.572_572delC | Frame_Shift_Del | 7 | 0.22 | NCIH522 | N | 6 | 0 | 0 | N | ||||||||||||
| TP53 | HHHHTGRLQ | OESOPHAGUS | 253 | p.I251fs | c.751_752insA | Frame_Shift_Ins | 7 | 0.22 | KYSE70 | N | 0 | 0 | 0 | N | ||||||||||||
| TP53 | HHHTGRLQW | OESOPHAGUS | 254 | p.I251fs | c.751_752insA | Frame_Shift_Ins | 7 | 0.22 | KYSE70 | N | 3 | 0 | 0 | N | ||||||||||||
| TP53 | RHPRPRHGH | STOMACH | 154 | p.P152fs | c.455_456insC | Frame_Shift_Ins | 7 | 0.22 | HGC27 | N | 0 | 0 | 0 | N | ||||||||||||
| TP53 | RHPRPRHGH | PANCREAS | 154 | p.P152fs | c.455_456insC | Frame_Shift_Ins | 7 | 0.22 | KP3 | N | 0 | 0 | 0 | N | ||||||||||||
| TP53 | TTGWRIFHP | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 322 | p.Q317fs | c.949_950insC | Frame_Shift_Ins | 7 | 0.22 | MEC1 | N | 0 | 0 | 0 | N | ||||||||||||
| TP53 | TTGWRIFHP | OESOPHAGUS | 322 | p.N310fs | c.929_930insA | Frame_Shift_Ins | 7 | 0.22 | OE19 | N | 0 | 0 | 0 | N | ||||||||||||
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