Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
TSHR	AFQGLCNEA	BREAST	171	p.T179A	c.535A>G	Missense_Mutation	1	0.11	HCC1569	N	1	0	0	N
TSHR	AHIVFVLTL	LUNG	581	p.Y582H	c.1744T>C	Missense_Mutation	1	0.11	NCIH510	N	10	0	0	N
TSHR	AKVSNCLPM	LUNG	564	p.I568N	c.1703T>A	Missense_Mutation	1	0.11	NCIH854	N	6	0	0	N
TSHR	ALAHIVFVL	LUNG	579	p.Y582H	c.1744T>C	Missense_Mutation	1	0.11	NCIH510	Y	13	12	0	N
TSHR	ALSYIVFVL	LARGE_INTESTINE	579	p.A581S	c.1741G>T	Missense_Mutation	1	0.11	HCT116	Y	12	9	0	N
TSHR	ALTLKLYNN	BREAST	179	p.T179A	c.535A>G	Missense_Mutation	1	0.11	HCC1569	N	0	0	0	N
TSHR	AMRLDQKIR	URINARY_TRACT	526	p.R531Q	c.1592G>A	Missense_Mutation	1	0.11	639V	N	4	0	0	N
TSHR	ASELSVYML	LUNG	504	p.T511M	c.1532C>T	Missense_Mutation	1	0.11	CORL23	Y	8	11	0	N
TSHR	CHLTPKKQG	OVARY	745	p.S745C	c.2234C>G	Missense_Mutation	1	0.11	OAW42	N	0	0	0	N
TSHR	CIAPISFYA	SKIN	636	p.M637I	c.1911G>A	Missense_Mutation	1	0.11	COLO679	N	2	0	0	N
TSHR	CIDPDALKE	LARGE_INTESTINE	116	p.Y116C	c.347A>G	Missense_Mutation	1	0.11	SNU1040	N	1	0	0	N
TSHR	CKCQAQAYR	ENDOMETRIUM	699	p.R701C	c.2101C>T	Missense_Mutation	1	0.11	ISHIKAWAHERAKLIO02ER	N	1	0	0	N
TSHR	CKDIQRIPC	LUNG	41	p.S49C	c.145A>T	Missense_Mutation	1	0.11	NCIH2172	N	1	0	0	N
TSHR	CLPPSTQTL	LUNG	49	p.S49C	c.145A>T	Missense_Mutation	1	0.11	NCIH2172	N	14	0	0	N
TSHR	CNEALTLKL	BREAST	176	p.T179A	c.535A>G	Missense_Mutation	1	0.11	HCC1569	N	7	0	0	N
TSHR	CNKAGFFTV	LUNG	494	p.T496K	c.1487C>A	Missense_Mutation	1	0.11	NCIH1793	Y	1	15	0	N
TSHR	CNMAGFFTV	OVARY	494	p.T496M	c.1487C>T	Missense_Mutation	1	0.11	COV644	N	3	0	0	N
TSHR	CQAQAYRGQ	ENDOMETRIUM	701	p.R701C	c.2101C>T	Missense_Mutation	1	0.11	ISHIKAWAHERAKLIO02ER	N	0	0	0	N
TSHR	CTPKSDEFD	LARGE_INTESTINE	398	p.N406D	c.1216A>G	Missense_Mutation	1	0.11	GP2D	N	0	0	0	N
TSHR	DEFDPCEDI	LARGE_INTESTINE	403	p.N406D	c.1216A>G	Missense_Mutation	1	0.11	GP2D	Y	8	9	0	Y
TSHR	DFICIAPIS	SKIN	633	p.M637I	c.1911G>A	Missense_Mutation	1	0.11	COLO679	N	0	0	0	N
TSHR	DFRVTSKDI	CENTRAL_NERVOUS_SYSTEM	36	p.C41S	c.122G>C	Missense_Mutation	1	0.11	DAOY	N	4	0	0	N
TSHR	DIQRIPCLP	LUNG	43	p.S49C	c.145A>T	Missense_Mutation	1	0.11	NCIH2172	N	0	0	0	N
TSHR	DKYAFGGVY	LARGE_INTESTINE	217	p.D219Y	c.655G>T	Missense_Mutation	1	0.11	SNU81	N	3	0	0	N
TSHR	DPCEDIMGY	LARGE_INTESTINE	406	p.N406D	c.1216A>G	Missense_Mutation	1	0.11	GP2D	N	12	0	0	N
TSHR	DQKIRLRHA	URINARY_TRACT	530	p.R531Q	c.1592G>A	Missense_Mutation	1	0.11	639V	N	4	0	0	N
TSHR	DTETPLALS	LARGE_INTESTINE	573	p.A581S	c.1741G>T	Missense_Mutation	1	0.11	HCT116	N	1	0	0	N
TSHR	DVYELIENC	OVARY	737	p.S745C	c.2234C>G	Missense_Mutation	1	0.11	OAW42	N	1	0	0	N
TSHR	EALTLKLYN	BREAST	178	p.T179A	c.535A>G	Missense_Mutation	1	0.11	HCC1569	N	3	0	0	N
TSHR	EDFRVTSKD	CENTRAL_NERVOUS_SYSTEM	35	p.C41S	c.122G>C	Missense_Mutation	1	0.11	DAOY	N	0	0	0	N
TSHR	EEDFRVTSK	CENTRAL_NERVOUS_SYSTEM	34	p.C41S	c.122G>C	Missense_Mutation	1	0.11	DAOY	Y	1	12	0	N
TSHR	EFDPCEDIM	LARGE_INTESTINE	404	p.N406D	c.1216A>G	Missense_Mutation	1	0.11	GP2D	N	3	0	0	Y
TSHR	ELIENCHLT	OVARY	740	p.S745C	c.2234C>G	Missense_Mutation	1	0.11	OAW42	N	2	0	0	N
TSHR	ELPLLKFFG	LUNG	124	p.L131F	c.391C>T	Missense_Mutation	1	0.11	NCIH2106	N	0	0	0	N
TSHR	ELSVYMLTV	LUNG	506	p.T511M	c.1532C>T	Missense_Mutation	1	0.11	CORL23	Y	5	11	0	N
TSHR	ENCHLTPKK	OVARY	743	p.S745C	c.2234C>G	Missense_Mutation	1	0.11	OAW42	N	0	0	0	N
TSHR	ESHSLYNLS	OESOPHAGUS	93	p.F97L	c.291C>G	Missense_Mutation	1	0.11	KYSE450	N	2	0	0	N
TSHR	ETPLALAHI	LUNG	575	p.Y582H	c.1744T>C	Missense_Mutation	1	0.11	NCIH510	Y	5	11	0	N
TSHR	ETPLALSYI	LARGE_INTESTINE	575	p.A581S	c.1741G>T	Missense_Mutation	1	0.11	HCT116	Y	5	12	0	N
TSHR	EVSQTSVTA	LUNG	232	p.D232E	c.696C>A	Missense_Mutation	1	0.11	DMS454	N	2	0	0	N
TSHR	FAMRLDQKI	URINARY_TRACT	525	p.R531Q	c.1592G>A	Missense_Mutation	1	0.11	639V	N	10	0	0	N
TSHR	FASELSVYM	LUNG	503	p.T511M	c.1532C>T	Missense_Mutation	1	0.11	CORL23	N	10	0	3	N
TSHR	FDPCEDIMG	LARGE_INTESTINE	405	p.N406D	c.1216A>G	Missense_Mutation	1	0.11	GP2D	N	3	0	0	Y
TSHR	FFGIFNTGL	LUNG	130	p.L131F	c.391C>T	Missense_Mutation	1	0.11	NCIH2106	N	10	0	14	N
TSHR	FGICKCQAQ	ENDOMETRIUM	696	p.R701C	c.2101C>T	Missense_Mutation	1	0.11	ISHIKAWAHERAKLIO02ER	N	2	0	17	N
TSHR	FGIFNTGLK	LUNG	131	p.L131F	c.391C>T	Missense_Mutation	1	0.11	NCIH2106	N	3	0	14	N
TSHR	FICIAPISF	SKIN	634	p.M637I	c.1911G>A	Missense_Mutation	1	0.11	COLO679	N	5	0	15	N
TSHR	FLHLTWADL	LARGE_INTESTINE	269	p.R274W	c.820C>T	Missense_Mutation	1	0.11	RKO	Y	15	12	1	N
TSHR	FLRIVVWLV	LARGE_INTESTINE	416	p.F423L	c.1267T>C	Missense_Mutation	1	0.11	GP2D	Y	9	11	20	N
TSHR	FQGLCNEAL	BREAST	172	p.T179A	c.535A>G	Missense_Mutation	1	0.11	HCC1569	N	11	0	9	N
TSHR	FRVTSKDIQ	CENTRAL_NERVOUS_SYSTEM	37	p.C41S	c.122G>C	Missense_Mutation	1	0.11	DAOY	N	3	0	12	N
TSHR	FSFLHLTRA	PROSTATE	267	p.L267F	c.801G>T	Missense_Mutation	1	0.11	LNCAPCLONEFGC	N	7	0	0	N
TSHR	FTDFICIAP	SKIN	631	p.M637I	c.1911G>A	Missense_Mutation	1	0.11	COLO679	N	3	0	0	N
TSHR	FVLTLIIVA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	585	p.N590I	c.1769_1770AC>TT	Missense_Mutation	1	0.11	COLO775	N	6	0	34	N
TSHR	GCNKAGFFT	LUNG	493	p.T496K	c.1487C>A	Missense_Mutation	1	0.11	NCIH1793	N	0	0	0	N
TSHR	GCNMAGFFT	OVARY	493	p.T496M	c.1487C>T	Missense_Mutation	1	0.11	COV644	N	0	0	0	N
TSHR	GICKCQAQA	ENDOMETRIUM	697	p.R701C	c.2101C>T	Missense_Mutation	1	0.11	ISHIKAWAHERAKLIO02ER	N	0	0	0	N
TSHR	GLCNEALTL	BREAST	174	p.T179A	c.535A>G	Missense_Mutation	1	0.11	HCC1569	Y	9	12	0	N
TSHR	GMYLLLITS	THYROID	464	p.A471T	c.1411G>A	Missense_Mutation	1	0.11	FTC133	N	3	0	0	N
TSHR	GPGCNKAGF	LUNG	491	p.T496K	c.1487C>A	Missense_Mutation	1	0.11	NCIH1793	N	11	0	0	N
TSHR	GPGCNMAGF	OVARY	491	p.T496M	c.1487C>T	Missense_Mutation	1	0.11	COV644	N	10	0	0	N
TSHR	GPSLLEVSQ	LUNG	227	p.D232E	c.696C>A	Missense_Mutation	1	0.11	DMS454	N	0	0	0	N
TSHR	HFLMCNLAF	STOMACH	450	p.R450H	c.1349G>A	Missense_Mutation	1	0.11	SNU620	N	5	0	0	N
TSHR	HIVFVLTLN	LUNG	582	p.Y582H	c.1744T>C	Missense_Mutation	1	0.11	NCIH510	N	0	0	0	N
TSHR	HLTWADLSY	LARGE_INTESTINE	271	p.R274W	c.820C>T	Missense_Mutation	1	0.11	RKO	N	7	0	0	N
TSHR	HSLYNLSKV	OESOPHAGUS	95	p.F97L	c.291C>G	Missense_Mutation	1	0.11	KYSE450	N	8	0	0	N
TSHR	HYKLNVPHF	STOMACH	443	p.R450H	c.1349G>A	Missense_Mutation	1	0.11	SNU620	Y	4	10	0	N
TSHR	HYKLNVPRV	LUNG	443	p.F451V	c.1351T>G	Missense_Mutation	1	0.11	SW900	Y	3	13	0	N
TSHR	IAPISFYAL	SKIN	637	p.M637I	c.1911G>A	Missense_Mutation	1	0.11	COLO679	Y	18	10	2	N
TSHR	ICIAPISFY	SKIN	635	p.M637I	c.1911G>A	Missense_Mutation	1	0.11	COLO679	N	6	0	0	N
TSHR	ICKCQAQAY	ENDOMETRIUM	698	p.R701C	c.2101C>T	Missense_Mutation	1	0.11	ISHIKAWAHERAKLIO02ER	N	6	0	0	N
TSHR	IDKYAFGGV	LARGE_INTESTINE	216	p.D219Y	c.655G>T	Missense_Mutation	1	0.11	SNU81	N	4	0	0	N
TSHR	IENCHLTPK	OVARY	742	p.S745C	c.2234C>G	Missense_Mutation	1	0.11	OAW42	N	1	0	0	N
TSHR	IFTDFICIA	SKIN	630	p.M637I	c.1911G>A	Missense_Mutation	1	0.11	COLO679	Y	3	9	8	N
TSHR	IIVAFVIVC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	590	p.N590I	c.1769_1770AC>TT	Missense_Mutation	1	0.11	COLO775	N	3	0	28	N
TSHR	IPCLPPSTQ	LUNG	47	p.S49C	c.145A>T	Missense_Mutation	1	0.11	NCIH2172	N	1	0	0	N
TSHR	IQRIPCLPP	LUNG	44	p.S49C	c.145A>T	Missense_Mutation	1	0.11	NCIH2172	N	0	0	13	N
TSHR	IQTHLRTIP	UPPER_AERODIGESTIVE_TRACT	60	p.E61Q	c.181G>C	Missense_Mutation	1	0.11	CAL27	N	0	0	0	N
TSHR	IRNTRNLTC	LARGE_INTESTINE	108	p.Y116C	c.347A>G	Missense_Mutation	1	0.11	SNU1040	N	3	0	19	N
TSHR	ISSYAKVSN	LUNG	560	p.I568N	c.1703T>A	Missense_Mutation	1	0.11	NCIH854	N	0	0	2	N
TSHR	ITFAMRLDQ	URINARY_TRACT	523	p.R531Q	c.1592G>A	Missense_Mutation	1	0.11	639V	N	0	0	22	N
TSHR	ITSVDLYTH	THYROID	470	p.A471T	c.1411G>A	Missense_Mutation	1	0.11	FTC133	N	0	0	0	N
TSHR	IVFVLTLII	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	583	p.N590I	c.1769_1770AC>TT	Missense_Mutation	1	0.11	COLO775	N	14	0	51	N
TSHR	IVVWLVSLL	LARGE_INTESTINE	419	p.F423L	c.1267T>C	Missense_Mutation	1	0.11	GP2D	Y	18	9	23	N
TSHR	KAGFFTVFA	LUNG	496	p.T496K	c.1487C>A	Missense_Mutation	1	0.11	NCIH1793	Y	4	10	0	N
TSHR	KCQAQAYRG	ENDOMETRIUM	700	p.R701C	c.2101C>T	Missense_Mutation	1	0.11	ISHIKAWAHERAKLIO02ER	N	0	0	0	N
TSHR	KDIQRIPCL	LUNG	42	p.S49C	c.145A>T	Missense_Mutation	1	0.11	NCIH2172	N	9	0	0	N
TSHR	KELPLLKFF	LUNG	123	p.L131F	c.391C>T	Missense_Mutation	1	0.11	NCIH2106	N	12	0	0	N
TSHR	KFFGIFNTG	LUNG	129	p.L131F	c.391C>T	Missense_Mutation	1	0.11	NCIH2106	N	0	0	0	N
TSHR	KFGICKCQA	ENDOMETRIUM	695	p.R701C	c.2101C>T	Missense_Mutation	1	0.11	ISHIKAWAHERAKLIO02ER	N	2	0	0	N
TSHR	KFLRIVVWL	LARGE_INTESTINE	415	p.F423L	c.1267T>C	Missense_Mutation	1	0.11	GP2D	Y	12	11	0	N
TSHR	KKLPLSFSF	PROSTATE	261	p.L267F	c.801G>T	Missense_Mutation	1	0.11	LNCAPCLONEFGC	N	5	0	0	N
TSHR	KLIQTHLRT	UPPER_AERODIGESTIVE_TRACT	58	p.E61Q	c.181G>C	Missense_Mutation	1	0.11	CAL27	N	4	0	0	N
TSHR	KLNVPHFLM	STOMACH	445	p.R450H	c.1349G>A	Missense_Mutation	1	0.11	SNU620	Y	8	9	0	N
TSHR	KLNVPRVLM	LUNG	445	p.F451V	c.1351T>G	Missense_Mutation	1	0.11	SW900	Y	6	11	0	N
TSHR	KLPLSFSFL	PROSTATE	262	p.L267F	c.801G>T	Missense_Mutation	1	0.11	LNCAPCLONEFGC	N	18	0	0	N
TSHR	KSDEFDPCE	LARGE_INTESTINE	401	p.N406D	c.1216A>G	Missense_Mutation	1	0.11	GP2D	N	1	0	0	N
TSHR	KVSNCLPMD	LUNG	565	p.I568N	c.1703T>A	Missense_Mutation	1	0.11	NCIH854	N	0	0	0	Y
TSHR	KYAFGGVYS	LARGE_INTESTINE	218	p.D219Y	c.655G>T	Missense_Mutation	1	0.11	SNU81	Y	2	11	0	N
TSHR	KYLTVIDKY	LARGE_INTESTINE	211	p.D219Y	c.655G>T	Missense_Mutation	1	0.11	SNU81	Y	5	9	0	N
TSHR	LAHIVFVLT	LUNG	580	p.Y582H	c.1744T>C	Missense_Mutation	1	0.11	NCIH510	N	3	0	0	N
TSHR	LALAHIVFV	LUNG	578	p.Y582H	c.1744T>C	Missense_Mutation	1	0.11	NCIH510	N	11	0	0	N
TSHR	LALSYIVFV	LARGE_INTESTINE	578	p.A581S	c.1741G>T	Missense_Mutation	1	0.11	HCT116	N	13	0	2	N
TSHR	LCNEALTLK	BREAST	175	p.T179A	c.535A>G	Missense_Mutation	1	0.11	HCC1569	N	2	0	0	N
TSHR	LDQKIRLRH	URINARY_TRACT	529	p.R531Q	c.1592G>A	Missense_Mutation	1	0.11	639V	N	0	0	4	N
TSHR	LESHSLYNL	OESOPHAGUS	92	p.F97L	c.291C>G	Missense_Mutation	1	0.11	KYSE450	Y	10	10	0	N
TSHR	LEVSQTSVT	LUNG	231	p.D232E	c.696C>A	Missense_Mutation	1	0.11	DMS454	N	5	0	0	N
TSHR	LHLTWADLS	LARGE_INTESTINE	270	p.R274W	c.820C>T	Missense_Mutation	1	0.11	RKO	N	1	0	3	N
TSHR	LIENCHLTP	OVARY	741	p.S745C	c.2234C>G	Missense_Mutation	1	0.11	OAW42	N	0	0	0	N
TSHR	LIFTDFICI	SKIN	629	p.M637I	c.1911G>A	Missense_Mutation	1	0.11	COLO679	N	16	0	4	N
TSHR	LIIVAFVIV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	589	p.N590I	c.1769_1770AC>TT	Missense_Mutation	1	0.11	COLO775	Y	7	10	5	N
TSHR	LIQTHLRTI	UPPER_AERODIGESTIVE_TRACT	59	p.E61Q	c.181G>C	Missense_Mutation	1	0.11	CAL27	N	4	0	2	N
TSHR	LITSVDLYT	THYROID	469	p.A471T	c.1411G>A	Missense_Mutation	1	0.11	FTC133	N	2	0	0	N
TSHR	LKFFGIFNT	LUNG	128	p.L131F	c.391C>T	Missense_Mutation	1	0.11	NCIH2106	N	1	0	14	N
TSHR	LKKLPLSFS	PROSTATE	260	p.L267F	c.801G>T	Missense_Mutation	1	0.11	LNCAPCLONEFGC	N	1	0	5	N
TSHR	LKLIQTHLR	UPPER_AERODIGESTIVE_TRACT	57	p.E61Q	c.181G>C	Missense_Mutation	1	0.11	CAL27	N	1	0	28	N
TSHR	LLEVSQTSV	LUNG	230	p.D232E	c.696C>A	Missense_Mutation	1	0.11	DMS454	N	5	0	0	N
TSHR	LLITSVDLY	THYROID	468	p.A471T	c.1411G>A	Missense_Mutation	1	0.11	FTC133	N	8	0	3	N
TSHR	LLKFFGIFN	LUNG	127	p.L131F	c.391C>T	Missense_Mutation	1	0.11	NCIH2106	N	2	0	2	N
TSHR	LLLITSVDL	THYROID	467	p.A471T	c.1411G>A	Missense_Mutation	1	0.11	FTC133	N	15	0	17	N
TSHR	LNVPHFLMC	STOMACH	446	p.R450H	c.1349G>A	Missense_Mutation	1	0.11	SNU620	N	1	0	0	N
TSHR	LNVPRVLMC	LUNG	446	p.F451V	c.1351T>G	Missense_Mutation	1	0.11	SW900	Y	0	15	9	N
TSHR	LPLLKFFGI	LUNG	125	p.L131F	c.391C>T	Missense_Mutation	1	0.11	NCIH2106	N	20	0	0	N
TSHR	LPLSFSFLH	PROSTATE	263	p.L267F	c.801G>T	Missense_Mutation	1	0.11	LNCAPCLONEFGC	N	2	0	0	N
TSHR	LQQLESHSL	OESOPHAGUS	89	p.F97L	c.291C>G	Missense_Mutation	1	0.11	KYSE450	N	11	0	11	N
TSHR	LRIVVWLVS	LARGE_INTESTINE	417	p.F423L	c.1267T>C	Missense_Mutation	1	0.11	GP2D	N	2	0	48	N
TSHR	LSFLHLTWA	LARGE_INTESTINE	267	p.R274W	c.820C>T	Missense_Mutation	1	0.11	RKO	N	7	0	0	N
TSHR	LSFSFLHLT	PROSTATE	265	p.L267F	c.801G>T	Missense_Mutation	1	0.11	LNCAPCLONEFGC	N	1	0	0	N
TSHR	LSKFGICKC	ENDOMETRIUM	693	p.R701C	c.2101C>T	Missense_Mutation	1	0.11	ISHIKAWAHERAKLIO02ER	N	1	0	0	N
TSHR	LSVYMLTVI	LUNG	507	p.T511M	c.1532C>T	Missense_Mutation	1	0.11	CORL23	N	12	0	2	N
TSHR	LSVYTLTVV	OESOPHAGUS	507	p.I515V	c.1543A>G	Missense_Mutation	1	0.11	KYSE140	N	6	0	2	N
TSHR	LSYIVFVLT	LARGE_INTESTINE	580	p.A581S	c.1741G>T	Missense_Mutation	1	0.11	HCT116	N	2	0	0	N
TSHR	LTCIDPDAL	LARGE_INTESTINE	114	p.Y116C	c.347A>G	Missense_Mutation	1	0.11	SNU1040	N	5	0	0	N
TSHR	LTLIIVAFV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	587	p.N590I	c.1769_1770AC>TT	Missense_Mutation	1	0.11	COLO775	Y	11	10	14	N
TSHR	LTVIDKYAF	LARGE_INTESTINE	213	p.D219Y	c.655G>T	Missense_Mutation	1	0.11	SNU81	N	6	0	3	N
TSHR	LTVVTLERW	OESOPHAGUS	512	p.I515V	c.1543A>G	Missense_Mutation	1	0.11	KYSE140	N	3	0	0	N
TSHR	LTWADLSYP	LARGE_INTESTINE	272	p.R274W	c.820C>T	Missense_Mutation	1	0.11	RKO	N	0	0	0	N
TSHR	LVSLLALLG	LARGE_INTESTINE	423	p.F423L	c.1267T>C	Missense_Mutation	1	0.11	GP2D	N	0	0	35	N
TSHR	LYNLSKVTH	OESOPHAGUS	97	p.F97L	c.291C>G	Missense_Mutation	1	0.11	KYSE450	N	0	0	24	N
TSHR	MAGFFTVFA	OVARY	496	p.T496M	c.1487C>T	Missense_Mutation	1	0.11	COV644	Y	5	9	6	N
TSHR	MGMYLLLIT	THYROID	463	p.A471T	c.1411G>A	Missense_Mutation	1	0.11	FTC133	N	1	0	10	N
TSHR	MLTVITLER	LUNG	511	p.T511M	c.1532C>T	Missense_Mutation	1	0.11	CORL23	N	6	0	13	N
TSHR	MRLDQKIRL	URINARY_TRACT	527	p.R531Q	c.1592G>A	Missense_Mutation	1	0.11	639V	Y	8	10	24	N
TSHR	MYLLLITSV	THYROID	465	p.A471T	c.1411G>A	Missense_Mutation	1	0.11	FTC133	Y	8	10	7	N
TSHR	NCHLTPKKQ	OVARY	744	p.S745C	c.2234C>G	Missense_Mutation	1	0.11	OAW42	N	0	0	0	N
TSHR	NCLPMDTET	LUNG	568	p.I568N	c.1703T>A	Missense_Mutation	1	0.11	NCIH854	N	0	0	0	N
TSHR	NEALTLKLY	BREAST	177	p.T179A	c.535A>G	Missense_Mutation	1	0.11	HCC1569	Y	6	10	0	N
TSHR	NKAGFFTVF	LUNG	495	p.T496K	c.1487C>A	Missense_Mutation	1	0.11	NCIH1793	N	3	0	0	N
TSHR	NLTCIDPDA	LARGE_INTESTINE	113	p.Y116C	c.347A>G	Missense_Mutation	1	0.11	SNU1040	N	3	0	0	N
TSHR	NMAGFFTVF	OVARY	495	p.T496M	c.1487C>T	Missense_Mutation	1	0.11	COV644	Y	9	9	0	N
TSHR	NTRNLTCID	LARGE_INTESTINE	110	p.Y116C	c.347A>G	Missense_Mutation	1	0.11	SNU1040	N	0	0	0	N
TSHR	NVPHFLMCN	STOMACH	447	p.R450H	c.1349G>A	Missense_Mutation	1	0.11	SNU620	N	0	0	0	N
TSHR	NVPRVLMCN	LUNG	447	p.F451V	c.1351T>G	Missense_Mutation	1	0.11	SW900	N	0	0	0	N
TSHR	PCLPPSTQT	LUNG	48	p.S49C	c.145A>T	Missense_Mutation	1	0.11	NCIH2172	N	0	0	0	N
TSHR	PGCNKAGFF	LUNG	492	p.T496K	c.1487C>A	Missense_Mutation	1	0.11	NCIH1793	N	1	0	0	N
TSHR	PGCNMAGFF	OVARY	492	p.T496M	c.1487C>T	Missense_Mutation	1	0.11	COV644	N	0	0	0	N
TSHR	PHFLMCNLA	STOMACH	449	p.R450H	c.1349G>A	Missense_Mutation	1	0.11	SNU620	N	1	0	0	N
TSHR	PKSDEFDPC	LARGE_INTESTINE	400	p.N406D	c.1216A>G	Missense_Mutation	1	0.11	GP2D	N	0	0	0	N
TSHR	PLALAHIVF	LUNG	577	p.Y582H	c.1744T>C	Missense_Mutation	1	0.11	NCIH510	N	1	0	0	N
TSHR	PLALSYIVF	LARGE_INTESTINE	577	p.A581S	c.1741G>T	Missense_Mutation	1	0.11	HCT116	N	1	0	0	N
TSHR	PLLKFFGIF	LUNG	126	p.L131F	c.391C>T	Missense_Mutation	1	0.11	NCIH2106	N	3	0	0	N
TSHR	PLSFSFLHL	PROSTATE	264	p.L267F	c.801G>T	Missense_Mutation	1	0.11	LNCAPCLONEFGC	N	1	0	0	N
TSHR	PRVLMCNLA	LUNG	449	p.F451V	c.1351T>G	Missense_Mutation	1	0.11	SW900	N	1	0	0	N
TSHR	PSLLEVSQT	LUNG	228	p.D232E	c.696C>A	Missense_Mutation	1	0.11	DMS454	N	0	0	0	N
TSHR	QEEDFRVTS	CENTRAL_NERVOUS_SYSTEM	33	p.C41S	c.122G>C	Missense_Mutation	1	0.11	DAOY	N	3	0	0	N
TSHR	QGLCNEALT	BREAST	173	p.T179A	c.535A>G	Missense_Mutation	1	0.11	HCC1569	N	3	0	0	N
TSHR	QKIRLRHAC	URINARY_TRACT	531	p.R531Q	c.1592G>A	Missense_Mutation	1	0.11	639V	N	1	0	0	N
TSHR	QLESHSLYN	OESOPHAGUS	91	p.F97L	c.291C>G	Missense_Mutation	1	0.11	KYSE450	N	1	0	0	N
TSHR	QQLESHSLY	OESOPHAGUS	90	p.F97L	c.291C>G	Missense_Mutation	1	0.11	KYSE450	N	6	0	0	N
TSHR	QRIPCLPPS	LUNG	45	p.S49C	c.145A>T	Missense_Mutation	1	0.11	NCIH2172	N	3	0	0	N
TSHR	QTGPGCNKA	LUNG	489	p.T496K	c.1487C>A	Missense_Mutation	1	0.11	NCIH1793	N	1	0	0	N
TSHR	QTGPGCNMA	OVARY	489	p.T496M	c.1487C>T	Missense_Mutation	1	0.11	COV644	N	1	0	0	N
TSHR	QTHLRTIPS	UPPER_AERODIGESTIVE_TRACT	61	p.E61Q	c.181G>C	Missense_Mutation	1	0.11	CAL27	N	0	0	0	N
TSHR	QTLKLIQTH	UPPER_AERODIGESTIVE_TRACT	55	p.E61Q	c.181G>C	Missense_Mutation	1	0.11	CAL27	N	0	0	0	N
TSHR	RIPCLPPST	LUNG	46	p.S49C	c.145A>T	Missense_Mutation	1	0.11	NCIH2172	N	0	0	0	N
TSHR	RIVVWLVSL	LARGE_INTESTINE	418	p.F423L	c.1267T>C	Missense_Mutation	1	0.11	GP2D	N	15	0	0	N
TSHR	RLDQKIRLR	URINARY_TRACT	528	p.R531Q	c.1592G>A	Missense_Mutation	1	0.11	639V	N	6	0	0	N
TSHR	RNLTCIDPD	LARGE_INTESTINE	112	p.Y116C	c.347A>G	Missense_Mutation	1	0.11	SNU1040	N	1	0	0	N
TSHR	RNTRNLTCI	LARGE_INTESTINE	109	p.Y116C	c.347A>G	Missense_Mutation	1	0.11	SNU1040	N	4	0	0	N
TSHR	RVLMCNLAF	LUNG	450	p.F451V	c.1351T>G	Missense_Mutation	1	0.11	SW900	N	9	0	0	N
TSHR	RVTSKDIQR	CENTRAL_NERVOUS_SYSTEM	38	p.C41S	c.122G>C	Missense_Mutation	1	0.11	DAOY	N	6	0	0	N
TSHR	SDEFDPCED	LARGE_INTESTINE	402	p.N406D	c.1216A>G	Missense_Mutation	1	0.11	GP2D	N	0	0	0	N
TSHR	SELSVYMLT	LUNG	505	p.T511M	c.1532C>T	Missense_Mutation	1	0.11	CORL23	N	7	0	0	N
TSHR	SFLHLTWAD	LARGE_INTESTINE	268	p.R274W	c.820C>T	Missense_Mutation	1	0.11	RKO	N	0	0	0	N
TSHR	SFSFLHLTR	PROSTATE	266	p.L267F	c.801G>T	Missense_Mutation	1	0.11	LNCAPCLONEFGC	N	2	0	0	N
TSHR	SGPSLLEVS	LUNG	226	p.D232E	c.696C>A	Missense_Mutation	1	0.11	DMS454	N	1	0	0	N
TSHR	SHSLYNLSK	OESOPHAGUS	94	p.F97L	c.291C>G	Missense_Mutation	1	0.11	KYSE450	N	0	0	0	N
TSHR	SHYKLNVPH	STOMACH	442	p.R450H	c.1349G>A	Missense_Mutation	1	0.11	SNU620	N	0	0	0	N
TSHR	SKDIQRIPS	CENTRAL_NERVOUS_SYSTEM	41	p.C41S	c.122G>C	Missense_Mutation	1	0.11	DAOY	N	1	0	0	N
TSHR	SKFGICKCQ	ENDOMETRIUM	694	p.R701C	c.2101C>T	Missense_Mutation	1	0.11	ISHIKAWAHERAKLIO02ER	N	0	0	0	N
TSHR	SLLEVSQTS	LUNG	229	p.D232E	c.696C>A	Missense_Mutation	1	0.11	DMS454	N	0	0	0	N
TSHR	SLSFLHLTW	LARGE_INTESTINE	266	p.R274W	c.820C>T	Missense_Mutation	1	0.11	RKO	N	3	0	0	N
TSHR	SLYNLSKVT	OESOPHAGUS	96	p.F97L	c.291C>G	Missense_Mutation	1	0.11	KYSE450	N	4	0	0	N
TSHR	SNCLPMDTE	LUNG	567	p.I568N	c.1703T>A	Missense_Mutation	1	0.11	NCIH854	N	0	0	0	N
TSHR	SSYAKVSNC	LUNG	561	p.I568N	c.1703T>A	Missense_Mutation	1	0.11	NCIH854	N	1	0	0	N
TSHR	STQTLKLIQ	UPPER_AERODIGESTIVE_TRACT	53	p.E61Q	c.181G>C	Missense_Mutation	1	0.11	CAL27	N	0	0	0	N
TSHR	SVYMLTVIT	LUNG	508	p.T511M	c.1532C>T	Missense_Mutation	1	0.11	CORL23	N	2	0	0	N
TSHR	SVYTLTVVT	OESOPHAGUS	508	p.I515V	c.1543A>G	Missense_Mutation	1	0.11	KYSE140	N	2	0	0	N
TSHR	SYAKVSNCL	LUNG	562	p.I568N	c.1703T>A	Missense_Mutation	1	0.11	NCIH854	Y	8	10	0	N
TSHR	SYIVFVLTL	LARGE_INTESTINE	581	p.A581S	c.1741G>T	Missense_Mutation	1	0.11	HCT116	Y	12	10	0	N
TSHR	TCIDPDALK	LARGE_INTESTINE	115	p.Y116C	c.347A>G	Missense_Mutation	1	0.11	SNU1040	N	3	0	0	N
TSHR	TDFICIAPI	SKIN	632	p.M637I	c.1911G>A	Missense_Mutation	1	0.11	COLO679	Y	6	9	0	N
TSHR	TETPLALAH	LUNG	574	p.Y582H	c.1744T>C	Missense_Mutation	1	0.11	NCIH510	N	0	0	0	N
TSHR	TETPLALSY	LARGE_INTESTINE	574	p.A581S	c.1741G>T	Missense_Mutation	1	0.11	HCT116	N	8	0	0	N
TSHR	TFAMRLDQK	URINARY_TRACT	524	p.R531Q	c.1592G>A	Missense_Mutation	1	0.11	639V	N	1	0	0	N
TSHR	TGPGCNKAG	LUNG	490	p.T496K	c.1487C>A	Missense_Mutation	1	0.11	NCIH1793	N	1	0	0	N
TSHR	TGPGCNMAG	OVARY	490	p.T496M	c.1487C>T	Missense_Mutation	1	0.11	COV644	N	1	0	0	N
TSHR	TLIIVAFVI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	588	p.N590I	c.1769_1770AC>TT	Missense_Mutation	1	0.11	COLO775	N	11	0	0	N
TSHR	TLKKLPLSF	PROSTATE	259	p.L267F	c.801G>T	Missense_Mutation	1	0.11	LNCAPCLONEFGC	N	5	0	0	N
TSHR	TLKLIQTHL	UPPER_AERODIGESTIVE_TRACT	56	p.E61Q	c.181G>C	Missense_Mutation	1	0.11	CAL27	N	9	0	0	N
TSHR	TLTVVTLER	OESOPHAGUS	511	p.I515V	c.1543A>G	Missense_Mutation	1	0.11	KYSE140	N	6	0	0	N
TSHR	TPKSDEFDP	LARGE_INTESTINE	399	p.N406D	c.1216A>G	Missense_Mutation	1	0.11	GP2D	N	0	0	0	N
TSHR	TPLALAHIV	LUNG	576	p.Y582H	c.1744T>C	Missense_Mutation	1	0.11	NCIH510	Y	13	11	0	N
TSHR	TPLALSYIV	LARGE_INTESTINE	576	p.A581S	c.1741G>T	Missense_Mutation	1	0.11	HCT116	N	13	0	0	N
TSHR	TQTLKLIQT	UPPER_AERODIGESTIVE_TRACT	54	p.E61Q	c.181G>C	Missense_Mutation	1	0.11	CAL27	N	2	0	0	N
TSHR	TRNLTCIDP	LARGE_INTESTINE	111	p.Y116C	c.347A>G	Missense_Mutation	1	0.11	SNU1040	N	1	0	0	N
TSHR	TSKDIQRIP	CENTRAL_NERVOUS_SYSTEM	40	p.C41S	c.122G>C	Missense_Mutation	1	0.11	DAOY	N	0	0	0	N
TSHR	TSVDLYTHS	THYROID	471	p.A471T	c.1411G>A	Missense_Mutation	1	0.11	FTC133	N	1	0	0	N
TSHR	TVIDKYAFG	LARGE_INTESTINE	214	p.D219Y	c.655G>T	Missense_Mutation	1	0.11	SNU81	N	0	0	0	Y
TSHR	TVVTLERWY	OESOPHAGUS	513	p.I515V	c.1543A>G	Missense_Mutation	1	0.11	KYSE140	N	3	0	0	N
TSHR	TWADLSYPS	LARGE_INTESTINE	273	p.R274W	c.820C>T	Missense_Mutation	1	0.11	RKO	N	0	0	0	N
TSHR	VFVLTLIIV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	584	p.N590I	c.1769_1770AC>TT	Missense_Mutation	1	0.11	COLO775	Y	5	9	9	N
TSHR	VIDKYAFGG	LARGE_INTESTINE	215	p.D219Y	c.655G>T	Missense_Mutation	1	0.11	SNU81	N	0	0	0	N
TSHR	VLMCNLAFA	LUNG	451	p.F451V	c.1351T>G	Missense_Mutation	1	0.11	SW900	Y	10	10	22	N
TSHR	VLTLIIVAF	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	586	p.N590I	c.1769_1770AC>TT	Missense_Mutation	1	0.11	COLO775	Y	7	9	3	N
TSHR	VPHFLMCNL	STOMACH	448	p.R450H	c.1349G>A	Missense_Mutation	1	0.11	SNU620	Y	18	10	0	N
TSHR	VPRVLMCNL	LUNG	448	p.F451V	c.1351T>G	Missense_Mutation	1	0.11	SW900	Y	15	10	0	N
TSHR	VSNCLPMDT	LUNG	566	p.I568N	c.1703T>A	Missense_Mutation	1	0.11	NCIH854	N	1	0	0	Y
TSHR	VTLERWYAI	OESOPHAGUS	515	p.I515V	c.1543A>G	Missense_Mutation	1	0.11	KYSE140	Y	13	15	0	N
TSHR	VTSKDIQRI	CENTRAL_NERVOUS_SYSTEM	39	p.C41S	c.122G>C	Missense_Mutation	1	0.11	DAOY	N	5	0	1	N
TSHR	VVTLERWYA	OESOPHAGUS	514	p.I515V	c.1543A>G	Missense_Mutation	1	0.11	KYSE140	N	4	0	27	N
TSHR	VVWLVSLLA	LARGE_INTESTINE	420	p.F423L	c.1267T>C	Missense_Mutation	1	0.11	GP2D	N	6	0	41	N
TSHR	VWLVSLLAL	LARGE_INTESTINE	421	p.F423L	c.1267T>C	Missense_Mutation	1	0.11	GP2D	N	9	0	7	N
TSHR	VYELIENCH	OVARY	738	p.S745C	c.2234C>G	Missense_Mutation	1	0.11	OAW42	N	0	0	0	N
TSHR	VYMLTVITL	LUNG	509	p.T511M	c.1532C>T	Missense_Mutation	1	0.11	CORL23	Y	10	11	51	N
TSHR	VYSGPSLLE	LUNG	224	p.D232E	c.696C>A	Missense_Mutation	1	0.11	DMS454	N	0	0	0	N
TSHR	VYTLTVVTL	OESOPHAGUS	509	p.I515V	c.1543A>G	Missense_Mutation	1	0.11	KYSE140	Y	8	11	6	N
TSHR	WADLSYPSH	LARGE_INTESTINE	274	p.R274W	c.820C>T	Missense_Mutation	1	0.11	RKO	N	2	0	0	N
TSHR	WLVSLLALL	LARGE_INTESTINE	422	p.F423L	c.1267T>C	Missense_Mutation	1	0.11	GP2D	Y	22	11	2	N
TSHR	WQTGPGCNK	LUNG	488	p.T496K	c.1487C>A	Missense_Mutation	1	0.11	NCIH1793	N	4	0	0	N
TSHR	WQTGPGCNM	OVARY	488	p.T496M	c.1487C>T	Missense_Mutation	1	0.11	COV644	Y	9	9	1	N
TSHR	YAFGGVYSG	LARGE_INTESTINE	219	p.D219Y	c.655G>T	Missense_Mutation	1	0.11	SNU81	N	2	0	1	N
TSHR	YAKVSNCLP	LUNG	563	p.I568N	c.1703T>A	Missense_Mutation	1	0.11	NCIH854	N	2	0	0	Y
TSHR	YELIENCHL	OVARY	739	p.S745C	c.2234C>G	Missense_Mutation	1	0.11	OAW42	N	13	0	10	N
TSHR	YIVFVLTLI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	582	p.N590I	c.1769_1770AC>TT	Missense_Mutation	1	0.11	COLO775	N	12	0	12	N
TSHR	YKLNVPHFL	STOMACH	444	p.R450H	c.1349G>A	Missense_Mutation	1	0.11	SNU620	N	10	0	18	N
TSHR	YKLNVPRVL	LUNG	444	p.F451V	c.1351T>G	Missense_Mutation	1	0.11	SW900	N	9	0	23	N
TSHR	YLLLITSVD	THYROID	466	p.A471T	c.1411G>A	Missense_Mutation	1	0.11	FTC133	N	3	0	13	N
TSHR	YLTVIDKYA	LARGE_INTESTINE	212	p.D219Y	c.655G>T	Missense_Mutation	1	0.11	SNU81	N	6	0	0	N
TSHR	YMLTVITLE	LUNG	510	p.T511M	c.1532C>T	Missense_Mutation	1	0.11	CORL23	N	3	0	3	N
TSHR	YSGPSLLEV	LUNG	225	p.D232E	c.696C>A	Missense_Mutation	1	0.11	DMS454	N	7	0	0	N
TSHR	YTLTVVTLE	OESOPHAGUS	510	p.I515V	c.1543A>G	Missense_Mutation	1	0.11	KYSE140	N	2	0	1	N
TSHR	AVLIFIDFI	THYROID	627	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	CGTHW1	Y	14	10	0	N
TSHR	AVLIFIDFI	THYROID	627	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	SW579	Y	14	10	0	N
TSHR	FIDFICMAP	THYROID	631	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	CGTHW1	N	2	0	0	N
TSHR	FIDFICMAP	THYROID	631	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	SW579	N	2	0	0	N
TSHR	IDFICMAPI	THYROID	632	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	CGTHW1	N	10	0	0	N
TSHR	IDFICMAPI	THYROID	632	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	SW579	N	10	0	0	N
TSHR	IFIDFICMA	THYROID	630	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	CGTHW1	N	3	0	13	N
TSHR	IFIDFICMA	THYROID	630	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	SW579	N	3	0	13	N
TSHR	KRMAVLIFI	THYROID	624	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	CGTHW1	Y	8	9	0	N
TSHR	KRMAVLIFI	THYROID	624	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	SW579	Y	8	9	0	N
TSHR	LIFIDFICM	THYROID	629	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	CGTHW1	Y	10	9	8	N
TSHR	LIFIDFICM	THYROID	629	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	SW579	Y	10	9	8	N
TSHR	MAVLIFIDF	THYROID	626	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	CGTHW1	Y	8	9	0	N
TSHR	MAVLIFIDF	THYROID	626	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	SW579	Y	8	9	0	N
TSHR	RMAVLIFID	THYROID	625	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	CGTHW1	N	0	0	0	N
TSHR	RMAVLIFID	THYROID	625	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	SW579	N	0	0	0	N
TSHR	VLIFIDFIC	THYROID	628	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	CGTHW1	N	3	0	7	N
TSHR	VLIFIDFIC	THYROID	628	p.T632I	c.1895C>T	Missense_Mutation	1	0.22	SW579	N	3	0	7	N