| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| aspsirna2436 | AACUCCUCUGCGCAACUUU UUGAGGAGACGCGUUGAAA |
0 | 70 | -70 | KRAS | NA | NA | NA | 
|
|
| aspsirna3142 | UUGAGGCCUGGAUCUGUGC AACUCCGGACCUAGACACG |
0 | 9 | -9 | TP63 | Ectrodactily-ectodermal dysplasia and cleft lip/palate (EEC) | c.727C>T, p.Arg243Trp | rs12190883 |
|
|
| aspsirna3291 | CUCCCUCAUCUACUGUGUGCA GAGGGAGUAGAUGACACACGU |
58 | 42 | 16 | HTT | Huntington disease (HD) | NM_002111.7:c.6931T>C | rs362331 |
|
|
| aspsirna3312 | UGGAAGUCUGUGCCCUUGUGC ACCUUCAGACACGGGAACACG |
30 | 20 | 10 | HTT | Huntington disease (HD) | NM_002111.6:c.9810C>T | rs362307 |
|
|
| aspsirna3169 | UUUGGAAGUCUUCGCCCUUGUA AAACCUUCAGAAGCGGGAACAU |
85 | 33 | 52 | HTT | Huntington disease (HD) | rs362306 | rs362307 |
|
|
| aspsirna3177 | UUUGGAAGUCUUCGCCCUUGUA AAACCUUCAGAAGCGGGAACAU |
70 | 30 | 40 | HTT | Huntington disease (HD) | rs362307 | rs362307 |
|
|
| aspsirna2175 | CCCUCAUCUACUGUGUGCAU GGGAGUAGAUGACACACGUA |
75 | 40 | 35 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 |
|
|
| aspsirna3440 | CCCUCAUCUACUGUGUGCAU GGGAGUAGAUGACACACGUA |
75 | 40 | 35 | HTT | Huntington disease (HD) | NM_002111.7:c.6931T>C | rs362331 |
|
|
| aspsirna3450 | CCCUCAUCUACUGUGUGCAU GGGAGUAGAUGACACACGUA |
75 | 40 | 35 | HTT | Huntington disease (HD) | NM_002111.7:c.6931T>C | rs362331 |
|
|
| aspsirna3460 | CCCUCAUCUACUGUGUGCAU GGGAGUAGAUGACACACGUA |
75 | 40 | 35 | HTT | Huntington disease (HD) | NM_002111.7:c.6931T>C | rs362331 |
|
|
| aspsirna3470 | CCCUCAUCUACUGUGUGCAU GGGAGUAGAUGACACACGUA |
75 | 40 | 35 | HTT | Huntington disease (HD) | NM_002111.7:c.6931T>C | rs362331 |
|
|
| aspsirna3480 | CCCUCAUCUACUGUGUGCAU GGGAGUAGAUGACACACGUA |
75 | 40 | 35 | HTT | Huntington disease (HD) | NM_002111.7:c.6931T>C | rs362331 |
|
|
| aspsirna3490 | CCCUCAUCUACUGUGUGCAU GGGAGUAGAUGACACACGUA |
75 | 40 | 35 | HTT | Huntington disease (HD) | NM_002111.7:c.6931T>C | rs362331 |
|
|
| aspsirna3057 | ACACGGACUGCACGGAGAA UGUGCCUGACGUGCCUCUU |
65 | 35 | 30 | TGFBI | Lattice corneal dystrophy type I (LCDI) | c.370C>T,p.Arg124Cys | rs12190921 |
|
|
| aspsirna0586 | UCAAUUCUUGGCUGGCCUC AGUUAAGAACCGACCGGAG |
45 | 0 | 45 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.487C>T,p.Arg163Trp | rs59616921 |
|
|
| aspsirna0543 | UAAAGGCUUGCGCUUCUUC AUUUCCGAACGCGAAGAAG |
63 | 75 | -12 | LRRK2 | Parkinsons disease (PD) | c.4321C>T,p.Arg1441Cys | rs33939927 |
|
|
| aspsirna0086 | GAGUAAGCUAAAAACCAAC CUCAUUCGAUUUUUGGUUG |
27 | 96 | -69 | PRNP | Prion disease/Gerstmann-Straussler disease | c.314C>T,p.Pro105Leu | rs11538758 |
|
|
| aspsirna0094 | GAACAAGCUGAGUAAGCCA CUUGUUCGACUCAUUCGGU |
90 | 99 | -9 | PRNP | Prion disease/Gerstmann-Straussler disease | c.305C>T,p.Pro102Leu | rs74315401 |
|
|
| aspsirna0133 | GAACAAGCUGAGUAAGCCA CUUGUUCGACUCAUUCGGU |
90 | 99 | -9 | PRNP | Prion disease/Gerstmann-Straussler disease | c.305C>T,p.Pro102Leu | rs74315401 |
|
|
| aspsirna3501 | GAGUAAGCUAAAAACCAAC CUCAUUCGAUUUUUGGUUG |
27 | 96 | -69 | PRNP | Prion disease/Gerstmann-Straussler disease | c.314C>T,p.Pro105Leu | rs11538758 |
|
|
| aspsirna1012 | CUGAACCCCCUCAAAAGCC GACUUGGGGGAGUUUUCGG |
75 | 64 | 11 | COL1A1 | Osteogenesis Imperfecta (OI) | c.*88T>C | rs1061237 |
|
|
| aspsirna1015 | CUGAACCCCCUCAAAAGCC GACUUGGGGGAGUUUUCGG |
75 | 64 | 11 | COL1A1 | Osteogenesis Imperfecta (OI) | c.*88T>C | rs1061237 |
|
|
| aspsirna0564 | GCUCUUCUUCUUCUUAACU CGAGAAGAAGAAGAAUUGA |
Low efficacy | High efficacy | High discrimination | CHRNA1 | Congenital myasthenic syndrome (SCCMS) | c.737C>T,p.Ser271Phe | rs48335304 |
|
|
| aspsirna3070 | GCAUGAACUGGAGGCCCAU CGUACUUGACCUCCGGGUA |
60 | 20 | 40 | TP53 | Cancer | c.944C>T,p.R249W | rs58778208 |
|
|
| aspsirna3073 | GCAUGAACUGGAGGCCCAU CGUACUUGACCUCCGGGUA |
67 | 15 | 52 | TP53 | Cancer | c.944C>T,p.R249W | rs58778208 |
|
|
| aspsirna3076 | GCAUGAACUGGAGGCCCAU CGUACUUGACCUCCGGGUA |
80 | 30 | 50 | TP53 | Cancer | c.944C>T,p.R249W | rs58778208 |
|
|
| aspsirna3077 | GCAUGAACUGGAGGCCCAU CGUACUUGACCUCCGGGUA |
85 | 40 | 45 | TP53 | Cancer | c.944C>T,p.R249W | rs58778208 |
|
