| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| ASPsiRNA ID | Mutant allele/ASP-siRNA | Efficacy for mutant(%) |
Efficacy for wild (%) |
Relative Difference (%) | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
| aspsirna0197 | GUGGCCAGAUGGAAGUAAAAUC CACCGGUCUACCUUCAUUUUAG |
65 | 60 | 5 | MAPT | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | c.1960G>A,p.Val654Met | rs63750570 | 
|
|
| aspsirna0210 | GUGGCCAGAUGGAAGUAAAAUC CACCGGUCUACCUUCAUUUUAG |
65 | 60 | 5 | MAPT | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | c.1960G>A,p.Val654Met | rs63750570 |
|
|
| aspsirna0254 | ACUACAGCAUUGCUCAGUA UGAUGUCGUAACGAGUCAU |
77 | 65 | 12 | LRRK2 | Parkinsons disease (PD) | c.6055G>A,p.Gly2019Ser | rs34637584 |
|
|
| aspsirna0321 | GCCUGGUAUUCCCAGGCUC CGGACCAUAAGGGUCCGAG |
50 | 11 | 39 | COL7A1 | Dominant dystrophic epidermolysis bullosa(DDEB) | c.6127G>A,p.Gly2043Arg | rs12191283 |
|
|
| aspsirna0608 | UUCUCAGCUGGCCUCUUAC AAGAGUCGACCGGAGAAUG |
35 | 0 | 35 | KRT9 | Epidermolytic palmoplantar keratoderma (EPPK) | c.488G>A,p.Arg163Gln | rs57758262 |
|
|
| aspsirna0670 | CAGCAGCAACAGCAGCAGCAGC GUCGUCGUUGUCGUCGUCGUCG |
40 | 20 | 20 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 |
|
|
| aspsirna0860 | CAGCCAUGAACAAUGUCCA GUCGGUACUUGUUACAGGU |
NA | 10 | NA | ATXN7 | Spino Cerebellar Ataxia type-7 (SCA-7) | c.88_90CAG(7_17) | rs193922929 |
|
|
| aspsirna0889 | CUCAAAAACAAGUUUGCCU GAGUUUUUGUUCAAACGGA |
56 | 25 | 31 | KRT6a | Pachyonychia congenita (PC) | c.513C>A,p.Asn171Lys | rs59685571 |
|
|
| aspsirna1907 | CACCCUCAGGUGAGGGUGGGG GUGGGAGUCCACUCCCACCCC |
Moderate efficacy | Moderate efficacy | Poor discrimination | Myh6 | Human hypertrophic cardiomyopathy (HCM) | c.2384G>A,p.Arg795Gln | rs26760690 |
|
|
| aspsirna2022 | UUUAUAAGGAUCUCUCUGA AAAUAUUCCUAGAGAGACU |
82 | 30 | 52 | P. luciferase | NA | NA | NA |
|
|
| aspsirna3079 | AGGUGCAUGUUUGUGCCUGU UCCACGUACAAACACGGACA |
30 | 20 | 10 | TP53 | Cancer | NC_000005.10:g.144594367C>A | rs57315468 |
|
|
| aspsirna3085 | AGGUGCAUGUUUGUGCCUGU UCCACGUACAAACACGGACA |
35 | 20 | 15 | TP53 | Cancer | NC_000005.10:g.144594367C>A | rs57315468 |
|
|
| aspsirna3091 | AGGUGCAUGUUUGUGCCUGU UCCACGUACAAACACGGACA |
34 | 20 | 14 | TP53 | Cancer | NC_000005.10:g.144594367C>A | rs57315468 |
|
|
| aspsirna3194 | UCGACAUGUCCUUCCAGCA AGCUGUACAGGAAGGUCGU |
90 | 10 | 80 | TP63 | Ectrodactyly-Ectodermal Dysplasia-Clefting syndrome 3 (EEC3) | p.Arg132His,c.394G>A | rs19392114 |
|
|
| aspsirna3537 | GUGGCCAGAUGGAAGUAAAAUC CACCGGUCUACCUUCAUUUUAG |
65 | 60 | 5 | MAPT | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | c.1960G>A,p.Val654Met | rs63750570 |
|
|
| aspsirna3549 | GUGGCCAGAUGGAAGUAAAAUC CACCGGUCUACCUUCAUUUUAG |
65 | 60 | 5 | MAPT | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | c.1960G>A,p.Val654Met | rs63750570 |
|
|
| aspsirna3552 | GUGGCCAGAUGGAAGUAAAAUC CACCGGUCUACCUUCAUUUUAG |
70 | 68 | 2 | MAPT | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | c.1960G>A,p.Val654Met | rs63750570 |
|
|
| aspsirna3555 | GUGGCCAGAUGGAAGUAAAAUC CACCGGUCUACCUUCAUUUUAG |
70 | 68 | 2 | TOR1A | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | NA | NA |
|
|
| aspsirna3632 | UCAGAGAGAUCCUCAUAAA AGUCUUUCUAGGAGUAUUU |
90 | 92 | -2 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|
|
| aspsirna3708 | GGUUGGAGGAGAGAUGAUA CCAACUUCCUCUCUACUAU |
90 | 92 | -2 | PPIB/Cyclophilin B | PPIB-Related Osteogenesis Imperfecta (Type IX) | NA | NA |
|