ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
---|---|---|---|---|---|---|---|---|---|---|
ASPsiRNA ID | Mutant allele/ASP-siRNA | Efficacy for mutant(%) |
Efficacy for wild (%) |
Relative Difference (%) | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
aspsirna0670 | CAGCAGCAACAGCAGCAGCAGC GUCGUCGUUGUCGUCGUCGUCG |
40 | 20 | 20 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0671 | CAGCAGCAGAAGCAGCAGCAGC GUCGUCGUCUUCGUCGUCGUCG |
10 | Lowest effective | Moderate discrimination | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0672 | CAGAAGCAGCAGCAGCAGCAGC GUCUUCGUCGUCGUCGUCGUCG |
50 | Moderately effective | discriminative | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0673 | CAGCUGCAGCAGCAGCAGCAGC GUCGACGUCGUCGUCGUCGUCG |
20 | 0 | 20 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0674 | CAGCAACAGCAGCAGCAGCAGC GUCGUUGUCGUCGUCGUCGUCG |
38 | 12 | 26 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0675 | CAGCAGAAGCAGCAGCAGCAGC GUCGUCUUCGUCGUCGUCGUCG |
78 | 38 | 40 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0676 | CAGCAGCUGCAGCAGCAGCAGC GUCGUCGACGUCGUCGUCGUCG |
70 | 30 | 40 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0677 | CAGCAGCAUCAGCAGCAGCAGC GUCGUCGUAGUCGUCGUCGUCG |
20 | 5 | 15 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0678 | CAGCAGCAGUAGCAGCAGCAGC GUCGUCGUCAUCGUCGUCGUCG |
46 | 40 | 6 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0679 | CAGCAGCAGCUGCAGCAGCAGC GUCGUCGUCGACGUCGUCGUCG |
35 | 20 | 15 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0680 | CAGCAGCAGCAACAGCAGCAGC GUCGUCGUCGUUGUCGUCGUCG |
62 | 50 | 12 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0681 | CAGCAGCAGCAGAAGCAGCAGC GUCGUCGUCGUCUUCGUCGUCG |
57 | 40 | 17 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0682 | CAGCAGCAGCAGCAGAAGCAGC GUCGUCGUCGUCGUCUUCGUCG |
50 | 30 | 20 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0683 | CAGCAGCAAAAGCAGCAGCAGC GUCGUCGUUUUCGUCGUCGUCG |
64 | 27 | 37 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0684 | CAGCAGCAAAUGCAGCAGCAGC GUCGUCGUUUACGUCGUCGUCG |
47 | 22 | 25 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0685 | CAGCAGCUAAUGCAGCAGCAGC GUCGUCGAUUACGUCGUCGUCG |
35 | 30 | 5 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0686 | CAGAAGCAGAAGCAGAAGCAGC GUCUUCGUCUUCGUCUUCGUCG |
82 | 20 | 62 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 | ||
aspsirna0687 | CAACAGCUGCAGAAGCUGCAGC GUUGUCGACGUCUUCGACGUCG |
60 | 10 | 50 | HTT | Huntington disease (HD) | c.52CAG(36_39) | rs19392295 |